Population-based prevalence and incidence estimates of primary discoid lupus erythematosus from the Manhattan Lupus Surveillance Program

Abstract

ObjectiveEpidemiological data for primary discoid lupus erythematosus (pDLE) remain limited, particularly for racial/ethnic populations in the USA. The Manhattan Lupus Surveillance Program (MLSP) is a population-based retrospective registry of cases with SLE and related diseases including pDLE in Manhattan and was used to provide estimates of the prevalence and incidence of pDLE across major racial/ethnic populations.MethodsMLSP cases were identified from rheumatologists, hospitals and population databases. Two case definitions were used for pDLE: the primary case definition which was any physician diagnosis found in the chart and a secondary case definition which was limited to cases diagnosed by a rheumatologist and/or dermatologist. Rates among Manhattan residents were age-adjusted, and capture–recapture analyses were conducted to assess case under-ascertainment.ResultsBased on the primary definition, age-adjusted overall prevalence and incidence rates of pDLE among Manhattan residents were 6.5 and 0.8 per 100 000 person-years, which increased to 9.0 and 1.3 after capture–recapture adjustment. Prevalence and incidence rates were approximately two and six times higher, respectively, among women compared with men (p<0.0001). Higher prevalence was also found among non-Latino blacks (23.5) and Latinos (8.2) compared with non-Latino whites (1.8) and non-Latino Asians (0.6) (p<0.0001). Incidence was highest among non-Latino blacks (2.4) compared with all other racial/ethnic groups. Similar relationships were observed for the secondary case definition.ConclusionData from the MLSP provide epidemiological estimates for pDLE among the major racial/ethnic populations in the USA and reveal disparities in pDLE prevalence and incidence by sex and race/ethnicity among Manhattan residents.

Discoid lupus erythematosus skin lesion distribution and characteristics in Black patients: a retrospective cohort study

“…Limitations of this study include its single-centre design and small sample size. However, the racial diversity of the UTSW CLE cohort is consistent with other epidemiological studies of DLE 12 13. Further multicentre studies are needed to confirm our findings.…”

Prevalence of Systemic Lupus Erythematosus in the United States: Estimates From a Meta‐Analysis of the Centers for Disease Control and Prevention National Lupus Registries

“…Sixth, our analyses did not include other forms of lupus, such as "early" or "incomplete" lupus, drug-induced lupus, or primary cutaneous lupus (14,15).…”

Modular gene analysis reveals distinct molecular signatures for subsets of patients with cutaneous lupus erythematosus*

“…1 Population-based studies have found that the incidence rate of CLE is approximately 4Á0-4Á3 per 100 000 1 and that it disproportionately affects females and African Americans. [2][3][4][5][6] CLE is traditionally divided into acute, subacute and chronic CLE (ACLE, SCLE and CCLE), based on disease duration. 7 CCLE has many subtypes, including discoid LE (DLE), LE tumidus and lupus panniculitis.…”