The incidence and patterns of pulmonary artery involvement in takayasu's arteritis

Childhood-onset Takayasu arteritis (c-TA) is a distinct subset affecting a wide age group, ranging from young infants to adolescents and it differs from adult TA in many aspects. There is scarcity of data on c-TA worldwide. The disease is classified using the European League Against Rheumatism/Pediatric Rheumatology International Trials Organization/Pediatric Rheumatology European Society criteria. The non-specific nature of presenting complaints and lack of appropriate biomarkers delay the early diagnosis of this illness and many children present with complications, which become irreversible once they set in. One of the largest cohorts of 40 children with c-TA from our center reports hypertension as the commonest presenting feature. Systemic symptoms like headache, fever and weight loss are also described. Assessment of disease in c-TA is done by correlating clinical features with raised inflammatory markers. Advanced imaging plays an important role in diagnosis. In c-TA, the role of magnetic resonance angiography is advocated, taking into consideration the enormous amount of radiation exposure with other modalities. Complications of c-TA include cardiovascular, pulmonary, neurological and those arising secondary to long-term steroid and immunosuppression therapy.

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“…47 This has also been described as a presenting feature of TA. Segmental and sub-segmental branches are commonly involved in the upper lobes.…”

Section: Lung Involvementmentioning

confidence: 91%

Childhood‐onset Takayasu arteritis: an update

et al. 2015

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“…52 The prevalence of angiographically proven pulmonary artery involvement among patients with Takayasu arteritis is poorly characterized, with values ranging from 14.3% to 70% in published series. [53][54][55][56] Stenotic or occlusive lesions are the most common abnormalities noted in the pulmonary arteries, although aneurysmal dilatation also has been described. 45 …”

Section: Takayasu Arteritismentioning

confidence: 99%

Aortitis

2008

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“…PA involvement was found in an average of 50% of cases studied. 6,7 In a study with 60 cases of Takayasu's arteritis, Kerr et al 8 demonstrated a 10-month delay between the onset of the first symptoms and diagnosis. It may have been challenging to distinguish these cases from primary lung disease and chronic pulmonary embolism.…”

Section: Discussionmentioning

confidence: 99%