Aortitis

Gornik, Heather L.; Creager, Mark A.

doi:10.1161/circulationaha.107.760686

Cited by 469 publications

(576 citation statements)

References 111 publications

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“…There are many conditions in which a high inflammatory state has been reported to be associated with AR dilatation,33, 34 thus the correlation between ARD and markers of inflammation, such as neutrophil percentage in the present study, was not a surprise 35. Our understanding of the role of the neutrophil in inflammation has changed fundamentally in recent years.…”

Section: Discussionmentioning

confidence: 49%

Hemodynamic Correlates of Abnormal Aortic Root Dimension in an Adult Population: The Strong Heart Study

Simone

Roman

Marco

et al. 2015

JAHA

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BackgroundWe evaluated the relationship of aortic root dimension (ARD) with flow output and both peripheral and central blood pressure, using multivariable equations predicting ideal sex‐specific ARD at a given age and body height.Methods and ResultsWe measured echocardiographic diastolic ARD at the sinuses of Valsalva in 3160 adults (aged 42±16 years, 61% women) from the fourth examination of the Strong Heart Study who were free of prevalent coronary heart disease, and we compared measured data with the theoretical predicted value to calculate a z score. Central blood pressure was estimated by applanation tonometry of the radial artery in 2319 participants. ARD z scores were divided into tertiles representing small, normal, and large ARD. Participants with large ARD exhibited greater prevalence of central obesity and higher levels of inflammatory markers and lipids (0.05

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Section: Discussionmentioning

confidence: 49%

Hemodynamic Correlates of Abnormal Aortic Root Dimension in an Adult Population: The Strong Heart Study

Simone

Roman

Marco

et al. 2015

JAHA

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“…1 Possible complications of IA include aneurysm formation with subsequent rupture and bleeding, aortic thrombosis with distal embolization (cerebral, visceral, or limb), aortic dissection, septic embolization, aortic insufficiency, and acute coronary syndromes caused by coronary involvement. 2 …”

Section: Clinical Presentationmentioning

confidence: 99%

“…2 However, diagnosis is frequently delayed since clinical manifestations are usually nonspecific or the first symptoms often result from expansion or rupture of an aneurysm. Infectious thoracic aortitis should always be considered in elderly patients with atherosclerosis, history of thoracic, abdominal, or back pain, and vague symptoms such as nausea, vomiting, and fever 4 Leukocytosis and neutrophilia are present in 65% to 83% of cases.…”

Section: Diagnosismentioning

confidence: 99%

“…1 Erythrocyte sedimentation rate and C-reactive protein are elevated in most of the patients. 2 Blood cultures are positive in 50% to 85% of the patients and a microorganism can be isolated from the excised aortic tissue in up to 76% of the patients. Pretreatment with antibiotics, the absence of an infectious focus in the aortic lumen, and the presence of anaerobic microorganisms are possible causes for negative blood and tissue cultures.…”

Section: Diagnosismentioning

confidence: 99%

“…It usually affects patients with prior atherosclerotic aorta disease and/or associated infective endocarditis (IE). 1,2 In the preantibiotic era, infectious thoracic aortitis was even more frequently related with IE, occurring in 86% of cases. 1 The infection can occur in normal or atherosclerotic aortas, aneurysms included, but is far more frequent in the latter case.…”

Section: Introductionmentioning

confidence: 99%

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Infectious Thoracic Aortitis: A Literature Review

Lopes

Almeida

Dias

et al. 2009

Clinical Cardiology

169

212

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Infectious thoracic aortitis (IA) remains a rare disease, especially after the appearance of antibiotics. However, if left untreated it is always lethal. It usually affects patients with atherosclerotic aortic disease and/or infective endocarditis. Mycotic aneurysm is the most common form of presentation, although a few reports of nonaneurysmal infectious thoracic aortitis have also been described. Various microorganisms have been associated with infectious thoracic aortitis, most commonly Staphylococcal, Enterococcus, Streptococcus, and Salmonella species. It is extremely important to establish an early diagnosis of IA, because this condition is potentially life‐threatening. However, diagnosis is frequently delayed since clinical manifestations are usually nonspecific. Antibiotherapy in combination with complete surgical excision of the infected aorta is the best choice of treatment. Copyright © 2009 Wiley Periodicals, Inc.

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Imaging of Medium and Large Vessels (CT/MR/PET)

Bley

2012

Inflammatory Diseases of Blood Vessels

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Aortitis

Cited by 469 publications

References 111 publications

Hemodynamic Correlates of Abnormal Aortic Root Dimension in an Adult Population: The Strong Heart Study

Hemodynamic Correlates of Abnormal Aortic Root Dimension in an Adult Population: The Strong Heart Study

Infectious Thoracic Aortitis: A Literature Review

Imaging of Medium and Large Vessels (CT/MR/PET)

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