The incidence and clinical analysis of non-melanoma skin cancer

Ciążyńska, Magdalena; Kamińska‐Winciorek, Grażyna; Lange, Dariusz; Lewandowski, Bogumił; Reich, Adam; Sławińska, Martyna; Pabianek, Marta; Szczepaniak, Katarzyna; Hankiewicz, Adam; Ułańska, Małgorzata; Morawiec, Jan; Błasińska-Morawiec, Maria; Morawiec, Zbigniew; Piekarski, Janusz; Nejc, Dariusz; Brodowski, Robert; Zaryczańska, Anna; Sobjanek, Michał; Nowicki, Roman; Owczarek, Witold; Słowińska, Monika; Wróbel, Katarzyna; Bieniek, Andrzej; Woźniacka, Anna; Skibińska, Małgorzata; Narbutt, Joanna; Niemczyk, Wojciech; Ciążyński, Karol; Lesiak, Aleksandra

doi:10.1038/s41598-021-83502-8

Cited by 124 publications

(78 citation statements)

References 38 publications

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“…In the study based on large sample (ca 13,000 participants) conducted by Ciążyńska et al, the incidence of BCC and SCC were reported 19 . All major areas on the body were taken into consideration.…”

Section: Discussionmentioning

confidence: 99%

Detailed head localization and incidence of skin cancers

Fijałkowska

Koziej

Antoszewski

2021

Sci Rep

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Skin cancers are the most common neoplasms; frequently, they localize on the face. The aim of paper is to present the incidence of skin tumors in a single center from 2017 to 2019, describe trends in its frequency and find relations between neoplasms and sex, type of cancer, and its size. An analysis of histopathological files from the surgical department between 2017 and 2019 was calculated. These items were selected: sex, age, type of skin cancer, subtype of basal cell carcinoma (BCC), grading of squamous cell carcinoma (SCC), localization and dimensions of the tumor. The study sample consisted of 387 cases. BCC was the most common cancer and its nodular type was the most frequent. In older patients, the vertical dimension of excised carcinoma was significantly larger. Moreover, this connection was detected only in women compared to men. There were statistically significant differences between dimensions of the skin cancer and sex. In men group, skin cancers had statistically higher vertical dimensions and larger surface areas. On the face and head, BCC more often localizes in the nasal area, while SCC on the auricle. It has been demonstrated that the older the patient, the larger the vertical dimension of the tumor. As such, tumor size is larger in men than in women, as women usually see their physicians sooner than men: cosmetic concerns are more important to them.

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Section: Discussionmentioning

confidence: 99%

Detailed head localization and incidence of skin cancers

Fijałkowska

Koziej

Antoszewski

2021

Sci Rep

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“…That is slightly higher than data reported from our neighbor Poland with (75.9 ± 12.2) years for men and (77.2 ± 12.1) years for women. 16 . A recent study from the MD Anderson Cancer Center in Texas with 916 patients reported an average age of 70 years 17 .…”

Section: Discussionmentioning

confidence: 99%

Cutaneous squamous cell carcinoma of head and neck region: A single center analysis of 1296 tumors with clinical characteristics, comorbidities, treatment, and sun‐protection behavior

Warnig

Wollina

2021

Dermatologic Therapy

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Cutaneous squamous cell carcinoma (SCC) is the second most common nonmelanoma skin cancer among Caucasians. We analyzed our data on tumors been treated between 2006 and 2016 at the Skin Cancer Center of an academic teaching hospital. Thousand hundred and ninety-four patients with 1296 SCC have been identified including 804 males (67.3%) and 390 females (32.7%). The mean age among females was significantly higher with (83.9 ± 7.9) years compared with males ([79.3 ± 8.1] years; P < .001). The most common tumor localizations were outer ears (n = 227, 17.5%), scalp (216, 16.7%), and forehead (215, 16.6%). The majority of tumors was stage I. 31.9% of patients had previous SCC or Bowen's cancer, 29.1% had actinic keratoses. Major non-dermatological comorbidities were cardiovascular diseases and diabetes. SCC were treated by delayed Mohs surgery. First Mohs procedure resulted in R0 status in 83.9%. Most cases with R1 resection were located on nose and eyelids. For a subpopulation of patients (n = 105), a structured questionnaire study evaluated changes in sun protection behavior after skin cancer. After the confirmed diagnosis of a cutaneous SCC concerns about harm to the skin by intense sunlight was reported by 78.4% (76) of participants, with 92.0% among females versus 73.6% among males. Eighty percent of females and 76.8% of males wanted to care more about sun-protection in the future, spend less time 84.0% (females) and 72.5% (males) in the sun, and adapt their leisure activities for a better sun protection in 92.0% (females) and 81.9% (males). Secondary prevention in males needs improvement.

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“…Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most common non-melanoma skin cancer types, with aging constituting a strong risk factor for their incidence [152,153]. TAM play a relevant role in the pathology of both types of cancer.…”

Section: Non-melanoma Skin Cancermentioning

confidence: 99%

Hallmarks of Aging in Macrophages: Consequences to Skin Inflammaging

Guimarães

Almeida

Santos

et al. 2021

Cells

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The skin is our largest organ and the outermost protective barrier. Its aging reflects both intrinsic and extrinsic processes resulting from the constant insults it is exposed to. Aging in the skin is accompanied by specific epigenetic modifications, accumulation of senescent cells, reduced cellular proliferation/tissue renewal, altered extracellular matrix, and a proinflammatory environment favoring undesirable conditions, including disease onset. Macrophages (Mφ) are the most abundant immune cell type in the skin and comprise a group of heterogeneous and plastic cells that are key for skin homeostasis and host defense. However, they have also been implicated in orchestrating chronic inflammation during aging. Since Mφ are related to innate and adaptive immunity, it is possible that age-modified skin Mφ promote adaptive immunity exacerbation and exhaustion, favoring the emergence of proinflammatory pathologies, such as skin cancer. In this review, we will highlight recent findings pertaining to the effects of aging hallmarks over Mφ, supporting the recognition of such cell types as a driving force in skin inflammaging and age-related diseases. We will also present recent research targeting Mφ as potential therapeutic interventions in inflammatory skin disorders and cancer.

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The incidence and clinical analysis of non-melanoma skin cancer

Cited by 124 publications

References 38 publications

Detailed head localization and incidence of skin cancers

Detailed head localization and incidence of skin cancers

Cutaneous squamous cell carcinoma of head and neck region: A single center analysis of 1296 tumors with clinical characteristics, comorbidities, treatment, and sun‐protection behavior

Hallmarks of Aging in Macrophages: Consequences to Skin Inflammaging

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