1972
DOI: 10.1016/0008-8749(72)90229-8
|View full text |Cite
|
Sign up to set email alerts
|

The in vitro induction and release of a cell toxin by immune C57B1/6 mouse peritoneal macrophages

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

2
21
0

Year Published

1974
1974
1989
1989

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 64 publications
(23 citation statements)
references
References 14 publications
2
21
0
Order By: Relevance
“…In accordance with our earlier findings (Keller, 1976a, b) the, range of target cell types differed considerably in their susceptibility to macrophage-mediated cytolysis; pointing to the important role of some as yet unidentified attributes of target cells. Earlier work had indicated that, contrary to the reports of others (Hibbs, 1974;Holtermann, Klein and Casale, 1973), there is no consistent correlation between degree of transformation and susceptibility to macrophagemediated cytocidal effects (Granger and Weiser, 1964;Kramer and Granger, 1972;McLaughling, Ruddle and Waksman, 1972;Nathan and Terry, 1975;Keller, 1974Keller, , 1976b). The present finding that primary explants from normal mouse epidermis and P815 mouse mastocytoma cells are comparably susceptible to the lytic effect, whereas SV40-transformed mouse macrophages are resistant, lends further support to the view that targetcell properties other than those associated with malignant transformation determine susceptibility to macrophage cytocidal effects.…”
Section: Fffector Capacities Of Adherent Cells From Different Rat Strmentioning
confidence: 77%
“…In accordance with our earlier findings (Keller, 1976a, b) the, range of target cell types differed considerably in their susceptibility to macrophage-mediated cytolysis; pointing to the important role of some as yet unidentified attributes of target cells. Earlier work had indicated that, contrary to the reports of others (Hibbs, 1974;Holtermann, Klein and Casale, 1973), there is no consistent correlation between degree of transformation and susceptibility to macrophagemediated cytocidal effects (Granger and Weiser, 1964;Kramer and Granger, 1972;McLaughling, Ruddle and Waksman, 1972;Nathan and Terry, 1975;Keller, 1974Keller, , 1976b). The present finding that primary explants from normal mouse epidermis and P815 mouse mastocytoma cells are comparably susceptible to the lytic effect, whereas SV40-transformed mouse macrophages are resistant, lends further support to the view that targetcell properties other than those associated with malignant transformation determine susceptibility to macrophage cytocidal effects.…”
Section: Fffector Capacities Of Adherent Cells From Different Rat Strmentioning
confidence: 77%
“…The adherent continuous lines used were L-929 cells, referred to as L-cells (17); HeLa, human cervical carcinoma; HT -1080, human skin fibrosarcoma; Chang, human liver carcinoma; T -24, human bladder carcinoma; \. ESH-7, a cell line derived from the fusion between HeLa .…”
Section: Methodsmentioning
confidence: 99%
“…a) Tube assay: The details of this method have been reported previously (17). Briefly, I X 105 mitomycin target cells in 1.0 ml were established as nondividing monolayers in l6X125-mm culture tubes.…”
Section: Methodsmentioning
confidence: 99%
“…Macrophages and certain continuous macrophage-like cell lines, from experimental animals and humans, can be stimulated to release materials with MCT activity in vitro (2,3). However, these effector cells and cell lines must first be raised to a tumoricidal state of activation before they can be stimulated to release MCT.…”
Section: Macrophage Cytotoxic Factorsmentioning
confidence: 99%
“…It has been known for a number of years that activated lymphocytes and macrophages from experimental animals and humans can be stimulated in vitro to release materials that are growth inhibitory and lytic for nucleated mammalian cells in vitro, Materials with these activities were termed lymphotoxins (LT) and macrophage cytotoxins (MCT), respectively (1,2). It is also evident that serum from bacillus Calmette Guerin (BCG)-infected and endotoxin-challenged animals contains a material(s) that causes selective necrosis of murine tumor's when injected into tumor-bearing mice.…”
Section: Introductionmentioning
confidence: 99%