The In Vitro Cytotoxicity of Eremothecium oil and Its Components—Aromatic and Acyclic Monoterpene Alcohols

Семенова, Е. Ф.; Presniakova, V.S.; Kozlovskaya, Vera; Маркелова, Н. Н.; Гусев, А. Н.; Linert, Wolfgang; Кураков, А. В.; Shpichka, Anastasia

doi:10.3390/ijms23063364

Cited by 4 publications

(2 citation statements)

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“…Although Trametes was a wood saprotroph and Eremothecium was a plant pathogen ( Fig. 4B ), the secondary metabolites of Eremothecium and Trametes had medicinal value ( Semenova et al, 2022 ; Zmitrovich, Ezhov & Wasser, 2012 ). Moreover, Hebeloma and Clavulinopsis were dominant genera in the rhizospheric soil of S. sphenanthera ( Table S6 ).…”

Section: Discussionmentioning

confidence: 99%

Microbial communities of Schisandra sphenanthera Rehd. et Wils. and the correlations between microbial community and the active secondary metabolites

Qin,

Pu,

Fang

et al. 2024

PeerJ

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Background Schisandra sphenanthera Rehd. et Wils. is a plant used in traditional Chinese medicine (TCM). However, great differences exist in the content of active secondary metabolites in various parts of S. sphenanthera. Do microorganisms critically influence the accumulation of active components in different parts of S. sphenanthera? Methods In this study, 16S/ITS amplicon sequencing analysis was applied to unravel microbial communities in rhizospheric soil and different parts of wild S. sphenanthera. At the same time, the active secondary metabolites in different parts were detected, and the correlation between the secondary metabolites and microorganisms was analyzed. Results The major components identified in the essential oils were sesquiterpene and oxygenated sesquiterpenes. The contents of essential oil components in fruit were much higher than that in stem and leaf, and the dominant essential oil components were different in these parts. The dominant components of the three parts were γ-muurolene, δ-cadinol, and trans farnesol (stem); α-cadinol and neoisolongifolene-8-ol (leaf); isosapathulenol, α-santalol, cedrenol, and longiverbenone (fruit). The microbial amplicon sequences were taxonomically grouped into eight (bacteria) and seven (fungi) different phyla. Community diversity and composition analyses showed that different parts of S. sphenanthera had similar and unique microbial communities, and functional prediction analysis showed that the main functions of microorganisms were related to metabolism. Moreover, the accumulation of secondary metabolites in S. sphenanthera was closely related to the microbial community composition, especially bacteria. In endophytic bacteria, Staphylococcus and Hypomicrobium had negative effects on five secondary metabolites, among which γ-muurolene and trans farnesol were the dominant components in the stem. That is, the dominant components in stems were greatly affected by microorganisms. Our results provided a new opportunity to further understand the effects of microorganisms on the active secondary metabolites and provided a basis for further research on the sustainable utilization of S. sphenanthera.

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Section: Discussionmentioning

confidence: 99%

Microbial communities of Schisandra sphenanthera Rehd. et Wils. and the correlations between microbial community and the active secondary metabolites

Qin,

Pu,

Fang

et al. 2024

PeerJ

View full text Add to dashboard Cite

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“…The secondary metabolites of Eremothecium and Trametes have medicinal value. Eremothecium can synthetize essential oil, which has a composition similar to that of rose oil (Semenova et al, 2022). Trametes versicolor, the most important medicinal mushrooms of Trametes, can produce polysaccharide krestin (PSK) and polysaccharide peptide (PSP), which can reduce cancer metastases (Zmitrovich et al, 2012).…”

Section: Fungal Function Analysis (Generic Level)mentioning

confidence: 99%

Community composition and differential analysis of rhizosphere soil microorganism and endophytes in Schisandra sphenanthera Rehd. et Wils.

Wang¹,

Qin²,

Han³

et al. 2022

Preprint

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Background and aims: Endophyte and rhizosphere soil microorganism are vital microbial environments of the plant, namely plant microenvironments. A robust understanding of the structural composition of the microbiome present in below-ground and above-ground communities has remained elusive. Schisandra sphenanthera Rehd. et Wils. is a kind of traditional Chinese Medicine (TCM) of Schisandra, which can protect the kidney and liver. Methods: In this study, high-throughput sequencing analysis is applied to unravel microbial communities in rhizosphere soil and different parts of wild S. sphenanthera, and the movement regularity of endophytes in plant tissues.Results: There are differences in microbial composition and diversity between rhizosphere soil and four parts of S. sphenanthera. Proteobacteria, Cyanobacteria, and Acidobacteria are main bacteria, Ascomycota and Basidiomycota are main fungi at phylum level of microbe in S. sphenanthera. There are 12 common bacterial genera and 11 common fungal genera in rhizosphere soil and different parts of S. sphenanthera. In addition, each of the four parts and rhizosphere soil have its own dominant communities, such as Achromobacter (stem and leaf) and Methylobacterium (leaf). OTUs clustering results indicate that the bacterial community of root is greatly influenced by rhizosphere soil, while the microbial community of stem and fruit are greatly affected by the microorganisms of leaf. Conclusions: Understanding the microbial community structure and diversity in rhizosphere soil and different parts of S. sphenanthera can provide basis for further study of host-microbial interactions of S. sphenanthera in phytoremediation, sustainable utilization, and secondary metabolite production.

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Design, synthesis, and in silico study of hybrid oxoazetidine conjugated thiazoles as anti‐EGFR with cytotoxicity activity

Pathak

Gupta

Grishina

et al. 2022

J Biochem & Molecular Tox

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We report a series of hybrid oxoazetidine conjugated thiazoles as epidermal growth factor receptor (EGFR) inhibitors, which were synthesized and tested using a variety of in silico and in vitro studies. The compounds were found to be active against breast and hepatic cancer cell lines, with Compounds 7a, 7b, and 7e being the most potent ones. The derivatives were also evaluated for molecular docking and complementarity studies to explicate fundamental substituent groups essential for their bioactivity. Moreover, the structural activity relationship of the analogues was performed for future compound optimization. These studies advocated that the analogues have a high affinity towards EGFR with favorable anticancer potential.The study advised that the derivatives have potency against breast and hepatic cancer and can assist as an initial scaffold for further development of anti-EGFR compounds.antitumor activity, hybrid oxoazetidine conjugated thiazoles, rational drug design | INTRODUCTIONCancer, a malignant disease, is the leading cause of death worldwide, and due to this millions of people lose their lives each year. [1] World Health Organization (WHO) propounded that the spread of cancers is higher in low-and middle-economic countries. [2,3] WHO official webpage [4] stated that cancer was accountable for 10 million deaths in 2020. It is also noted that patients with cancer have been impacted considerably due to increased morbidity and mortality from COVID-19 infection and delays in cancer therapy. [5] Much literature illustrates that numerous enzymes are intricate in signal recognition, transduction, and amplification followed by cell growth and division but among them, tyrosine kinases (TKs) are contemplated as one of the most important ones. [6,7] TKs generally participate in cell proliferation, metabolism, and apoptosis. Therefore, disturbance in TKs function leads to tumor growth and progression. [8] Functionally, TKs can be classified either as epidermal growth factor receptor (EGFR) or nonreceptor kinases. [9] EGFR belongs to the erbB/HERfamily of TKs, which is a transmembrane protein. These receptors comprise an extracellular ligand-binding domain, cysteine-binding domain, intracellular domain, and alpha-helix transmembrane domain with TK activity within the carboxy terminus (except for HER3). [10] EGFRs contribute to the regulatory molecular transcription through cell proliferation, differentiation, apoptosis, invasion, and angiogenesis followed by organ development. In tumor cells, EGFR signaling is changed, frequently develops dysregulated, and overexpresses and/ or obtains a gain-of-function mutation. [11][12][13][14][15][16] This performance facilitates the proliferation of tumor cells and invasion of the

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The In Vitro Cytotoxicity of Eremothecium oil and Its Components—Aromatic and Acyclic Monoterpene Alcohols

Cited by 4 publications

References 20 publications

Microbial communities of Schisandra sphenanthera Rehd. et Wils. and the correlations between microbial community and the active secondary metabolites

Microbial communities of Schisandra sphenanthera Rehd. et Wils. and the correlations between microbial community and the active secondary metabolites

Community composition and differential analysis of rhizosphere soil microorganism and endophytes in Schisandra sphenanthera Rehd. et Wils.

Design, synthesis, and in silico study of hybrid oxoazetidine conjugated thiazoles as anti‐EGFR with cytotoxicity activity

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