The improvement of renal survival with steroid pulse therapy in IgA nephropathy

Katafuchi, Ritsuko; Ninomiya, Toshiharu; Mizumasa, Tohru; Ikeda, Kiyoshi; Kumagai, Harumitsu; Nagata, Michio; Hirakata, Hideki

doi:10.1093/ndt/gfp090

Cited by 11 publications

(12 citation statements)

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“…In the early phase of inflammation, steroid pulse therapy immediately suppressed the inflammation in glomerulus. 10 Regarding steroid pulse therapy for cardiac sarcoidosis, this is the first case report in which steroid pulse therapy was effective in patient with cardiac sarcoidosis in active inflammation phase. Because cardiac sarcoidosis is a rare disease, large-scale randomized controlled trial is difficult to perform.…”

Section: Discussionmentioning

confidence: 92%

Steroid pulse therapy was effective for cardiac sarcoidosis with ventricular tachycardia and systolic dysfunction

et al. 2016

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A 32‐year‐old man presented with palpitation. He was diagnosed with pulmonary sarcoidosis by lung biopsy. The electrocardiogram showed first‐degree atrioventricular block and complete right bundle branch block (CRBBB). We planned to examine laboratory data, echocardiography, Holter monitoring, and gallium‐67 scintigraphy. Before he went through all these exams, he developed ventricular tachycardia. After defibrillation was performed, his electrocardiogram revealed complete atrioventricular block. We observed elevation of serum angiotensin‐converting enzyme levels. In addition, both of gallium‐67 scintigraphy and 18F‐fluorodeoxyglucose positron emission tomography showed abnormal uptake in the ventricular septum. We diagnosed the patient with cardiac sarcoidosis associated with these arrhythmias. We started treatment with methylprednisolone pulse therapy (1 g daily). After 3 days of steroid pulse therapy, we administered prednisolone 30 mg daily. On day 15, electrocardiogram changed from complete atrioventricular block to first‐degree atrioventricular block and CRBBB. He was discharged with no progression with cardiac sarcoidosis for 2 years.

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Section: Discussionmentioning

confidence: 92%

Steroid pulse therapy was effective for cardiac sarcoidosis with ventricular tachycardia and systolic dysfunction

et al. 2016

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“…Katafuchi et al. reported a glomerular score calculated as the sum of indices of the following three glomerular lesions: hypercellularity; segmental lesions including crescent, tuft necrosis, tuft adhesion, and segmental sclerosis; and global sclerosis. We defined the grade of renal injury as follows.…”

Section: Methodsmentioning

confidence: 99%

Outcome of tonsillectomy for recurrent IgA nephropathy after kidney transplantation

Koshino

Ushigome

Sakai

et al. 2013

Clinical Transplantation

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N. Outcome of tonsillectomy for recurrent IgA nephropathy after kidney transplantation.Abstract: Since 2007, we have performed tonsillectomies for patients with recurrent immunoglobulin A nephropathy (IgAN) after kidney transplantation. Seven patients with primary IgAN showed biopsyproven recurrent IgAN after living-donor kidney transplantation. They had persistent proteinuria or hematuria for an average of 40.3 months, and tonsillectomy was performed, on average, 75.6 months after kidney transplantation. In six patients with observation periods of more than one yr, good remission of urinary findings was observed after tonsillectomy. We classified the seven patients into three types of renal injury based on histological findings: severe, moderate, and mild. Two patients classified with severe renal injury at the time of tonsillectomy had other problems, such as refractory hypertension and bilateral sinusitis. They followed a rapidly progressive clinical course. One case already had moderate histological renal injury. He demonstrated prompt amelioration of urinary findings after tonsillectomy but immediate deviation from remission of proteinuria and hematuria. In the four cases presenting mild renal injury at tonsillectomy, the improved urinary findings and serum creatinine value after tonsillectomy have persisted.In conclusion, tonsillectomy may be a favorable treatment for cases of mild-grade IgAN. However, other treatments such as antihypertensive agents and diet therapy may be necessary in other grades.

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“…41,42 This is consistent with a retrospective analysis in 702 IgAN patients where corticosteroid pulse therapy as well as ACE-inhibitor therapy independently reduced progression of disease. 43 Both the trial of Manno et al and Lv et al 35,34 (Table 2) suffer from their study design, as patients were required to discontinue prior ACE inhibitor or angiotensin receptor blocker (ARB) therapy. Then, in the combination groups, they started receiving simultaneously an ACE inhibitor and corticosteroids.…”

Section: Nonestablished and Controversial Nonimmunosuppressive Treatmmentioning

confidence: 99%

Current Therapy for IgA Nephropathy

Floege

Eitner

2011

Journal of the American Society of Nephrology

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The improvement of renal survival with steroid pulse therapy in IgA nephropathy

Cited by 11 publications

References 0 publications

Steroid pulse therapy was effective for cardiac sarcoidosis with ventricular tachycardia and systolic dysfunction

Steroid pulse therapy was effective for cardiac sarcoidosis with ventricular tachycardia and systolic dysfunction

Outcome of tonsillectomy for recurrent IgA nephropathy after kidney transplantation

Current Therapy for IgA Nephropathy

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