The improvement of insulin resistance and the antioxidant capacity in type 2 diabetes mellitus rats with whiteleg shrimp shell powder (Litopenaeus vannamei)

Abstract

As estimated having an increased incidence of about 50% until 2040, the diabetic condition could be augmented primarily from astaxanthin contained in carotenoids. This research examines and compares the influence of WSSP and AST complement on Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) level and Total Antioxidant Capacity (TAC) induced high-fat diet streptozotocin (HFD-STZ) in T2DM rats. WSSP 0.89gr/200gr/d (X1) and 1.77gr/200gr/d (X2) groups; and AST supplement 0.09mg/200gr/d (X3) groups were compared with both of positive (K1) and negative (K2) groups. The treatments were administered orally for 21 days to 25 Wistar rats which each group consisted of 5 rats. HOMA-IR and TAC levels were measured by ELISA and ABTs method respectively. TAC levels significantly increased in treatment groups than K1 group (p = 0.008). The increase in the TAC level of the X2 group was greater than the X1 group (p = 0.017). HOMA IR levels were significantly lower in treatment groups than K1 group (p = 0.009). X2 group had a greater decrease in HOMA IR levels compared to X1 (p = 0.016). In consequence, the research findings show a utilitarian effect of WSSP in increasing TAC and decreasing the HOMA-IR index.

The Effect of Shrimp Shell (Litopenaeus vannamei) Extract on Testicular Parameters of Streptozotocin-induced Diabetic Rats

“…The use of astaxanthin in DM has been studied by many researchers (Feng et al, 2020;Landon et al, 2020;Ahriyasna et al, 2021;Wisaksono et al, 2021). However, the reproductive aspect in such studies has not been evaluated.…”

The effect of Kawa Daun (Coffea canephora) decoction on blood glucose levels and pancreatic β-cells regeneration in rats with diabetes

“…Moreover, an increasing amount of fatty acids circulating in vessels is generated due to oxidative stress, which positively will produce large amounts of Nitric Oxide (NO). This overproduction of NO presence may induce endoplasmic reticulum (ER) stress by reducing the level of Ca 2+ in ER; later on, it is toxic to pancreatic β-cells and finally results in these cells' death [24], [26]. Eventually, the flavonoid may interfere with the inflammation signalling cascades and positively prevent NO overproduction and its deleterious consequences in shock and ischemiareperfusion of tissue injury [27].…”