The Importance of Serum Adiponectin Concentrations during Pregnancy and Postpartum Period in Women with Gestational Diabetes Mellitus

Culha, Cavit

doi:10.4183/aeb.2011.173

Cited by 4 publications

(3 citation statements)

References 36 publications

(112 reference statements)

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“…Excessive insulin resistance during pregnancy is also observed in obese subjects without abnormal glucose tolerance [10]. Different studies found HOMA-IR values in the GDM group are significantly higher than in NGT patients, which indicated a significant insulin resistance [167,215,[233][234][235][236][237][238][239]. Some studies report controversial results.…”

Section: The Effect Of Bmi On Homeostasis Model Assessment Of Insulinmentioning

confidence: 99%

Body Mass Index and Insulin Sensitivity/Resistance: Cross Talks in Gestational Diabetes, Normal Pregnancy and Beyond

Genova¹,

Atanasova²,

Todorova-Ananieva³

2019

Body-Mass Index and Health

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Pregnancy is a complex of metabolic, physiological, biochemical, and immunological changes in women's body, usually reversible after delivery in normal pregnancy. Gestational diabetes mellitus (GDM) is defined as "any degree of glucose intolerance with onset or first recognition during the current pregnancy." The etiology of the GDM is multifactorial and not sufficiently elucidated. The overweight and obesity during prepregnancy and pregnancy are one of the main modifiable risk factors of GDM. Maternal obesity increases the risk of a number of pregnancy complications, adverse pregnancy outcome for mother and child, and related chronic conditions in women. The obesity prevalence is the greatest among children of obese mothers, and an independent association between maternal body mass index and offspring adiposity and insulin resistance exists. Although the underlying mechanism remains unclear, available evidence suggests that GDM pathogenesis is based on relatively diminished insulin secretion coupled with pregnancy-induced insulin resistance. Recent findings provide data that higher BMI leads to decreased insulin sensitivity and higher degree of insulin resistance and contributes to GDM development.

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Section: The Effect Of Bmi On Homeostasis Model Assessment Of Insulinmentioning

confidence: 99%

Body Mass Index and Insulin Sensitivity/Resistance: Cross Talks in Gestational Diabetes, Normal Pregnancy and Beyond

Genova¹,

Atanasova²,

Todorova-Ananieva³

2019

Body-Mass Index and Health

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“…Inflammation may configure the pathophysiological link between GDM and the risk for developing type 2 diabetes mellitus and cardiovascular disease (CVD) in the mother. The prevalence of GDM has been steadily increasing, which makes prevention of the disease and its complications the goal of patient management (6)(7)(8). Serum soluble interleukin-2 receptor (sIL2r) is a biomarker which is elevated in inflammatory disease processes, such as type I diabetes mellitus, type 2 Quick Response Code: Access this article online Website: www.gorm.com.tr e-mail: info@gorm.com.tr DOI:10.201613/GORM.2018.775 diabetes mellitus, hepatitis, and neoplasms (9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

A Study of Inflammatory Markers in Gestational Diabetes Mellitus

Mertoğlu¹,

Günay²,

Güngör³

et al. 2019

Gynecol Obstet Reprod Med

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Objective: Gestational diabetes mellitus is a common disorder of carbohydrate metabolism, with onset or first recognition during pregnancy, resulting in hyperglycemia of variable severity. Insulin resistance and chronic subclinical inflammation are the underlying mechanisms of the disease. Soluble interleukin-2 receptor, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio are the markers of inflammatory disease processes such as type 1 and 2 diabetes mellitus, hepatitis, and neoplasms.Study Design: In our study, we measured complete blood count, serum soluble interleukin-2 receptor, serum glucose in blood samples from 52 women with gestational diabetes mellitus and 50 pregnant women with normal glucose tolerance. Pregnant women which were tested for oral glucose tolerance test (75 gr load) between 24 and 28 weeks of pregnancy were selected for the study. Gestational diabetes mellitus was defined according to the criteria provided by the National Institute for Health and Care Excellence. Results: In terms of age, gestational diabetes mellitus patients (mean±SD; 31±6 years) were older than controls (mean±SD; 25±5.3 years). Mean platelet volume values were lower in gestational diabetes mellitus patients (mean±SD; 10.3±1.4 fL) as compared to normal glucose tolerance group (mean±SD; 10.8±1fL). No statistically significant differences in serum glucose concentration, white blood cell count, neutrophil count, lymphocyte count, hemoglobin concentration, platelet count, neutrophil-to-lymphocyte ratio value, platelet-to-lymphocyte ratio value, and serum soluble interleukin-2 receptor concentration were found. Conclusion: This study did not reveal an increase in the inflammatory markers, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and serum soluble interleukin-2 receptor, in gestational diabetes mellitus. The mean platelet volume values were observed to be lower in gestational diabetes mellitus patients.

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“…However, glucose tolerance and gestational diabetes could be affected by several factors such as anti-oxidant and fatty acids (32), and the role of adiponectins in the gestational diabetes has been reported (33).…”

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confidence: 99%

Gestational Diabetes Mellitus in Iranian Women: a rising rate

Manafi¹

2013

Acta Endo (Buc)

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Context. Rising incidence of Gestational diabetes mellitus (GDM) has been reported in the recent years and it has become an important public health problem, mainly among women aged 35-39 years.Objectives. Frequency of GDM in the females who are living in the northwest of Iran was evaluated.Subjects and Methods. Two hundred and fifty pregnant women at 24-28 th weeks of gestation were screened using 50 g oral glucose challenge test (OGCT), and the subjects with blood sugar levels equal or greater than 130 mg/dL were referred to diagnostic 100 g oral glucose tolerance test (OGTT). GDM was diagnosed according to Carpenter and Coustan criteria.Results. Eighty six women (34.4%) with positive result of screening test were selected for subsequent OGTT with 100g oral glucose. GDM was diagnosed in twenty four women (9.6 %) with at least 2 abnormal values. Frequency of GDM in the older subjects or the subjects with high pre-pregnancy or 24-28 th weeks' body mass index (BMI) were significantly higher than younger pregnant females or the subjects with low BMI.Conclusion. Prevalence of GDM in the current study was 11.9%, which is higher than earlier reports and implicates that the prevalence of gestational diabetes mellitus has markedly been increasing in Iran and associated with maternal age and body mass index.

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The Importance of Serum Adiponectin Concentrations during Pregnancy and Postpartum Period in Women with Gestational Diabetes Mellitus

Cited by 4 publications

References 36 publications

Body Mass Index and Insulin Sensitivity/Resistance: Cross Talks in Gestational Diabetes, Normal Pregnancy and Beyond

Body Mass Index and Insulin Sensitivity/Resistance: Cross Talks in Gestational Diabetes, Normal Pregnancy and Beyond

A Study of Inflammatory Markers in Gestational Diabetes Mellitus

Gestational Diabetes Mellitus in Iranian Women: a rising rate

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