A Study of Inflammatory Markers in Gestational Diabetes Mellitus

Mertoğlu, Cuma; Günay, Murat; Güngör, Mehmet Ali̇; Külhan, Mehmet; Kulhan, Nur Gözde

doi:10.21613/gorm.2018.775

Cited by 19 publications

(10 citation statements)

References 21 publications

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“…However, Sjaarda et al (2018) tested the inflammatory status by high-sensitive C-reactive protein (hs-CRP) and found that low-grade inflammation is very common (20-40%) in reproductive-age women, including normal-weight women. Apart from hs-CRP, systemic inflammatory status could be assessed by NLR, MLR, and PLR ( Mertoglu et al, 2019 ; Madendag et al, 2018 ) . On the other hand, platelets release a high rate of inflammatory mediators to the environment during inflammation ( Thomas & Storey, 2015 ) .…”

Section: Discussionmentioning

confidence: 99%

The Role of Inflammatory Hematological Markers in Predicting IVF Success

Özgü-Erdinç¹,

Çoşkun²,

Yorgancı³

et al. 2020

JBRA

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Objective: To investigate the predictive role of inflammatory hematological markers on treatment success in in vitro fertilization (IVF) patients. Methods: In this study, we analyzed the data from the patients who admitted to our IVF center, and we recorded demographic characteristics, medical histories, laboratory biomarkers, cycle characteristics, and IVF outcomes from the patients’ files. We assessed the value of white blood cell (WBC) counts, neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), platelet/lymphocyte (PLR), mean platelet volume (MPV) and platelet distribution width (PDW) of the patients from their complete blood count. We compared these values in terms of predicting positive HCG test after embryo transfer (ET). Results: There were 132 patients, of which 63 (47.7%) were treated for male factor, 43 (32.6%) for unexplained infertility, 19 (14.4%) for diminished ovarian reserve, 5 (3.8%) for endometriosis and 2 (1.5%) for hypogonadotropic hypogonadism. After ovarian stimulation and oocyte retrieval, 115 patients underwent embryo transfer, and 28 patients had a positive HCG test (24.3%). The positive HCG group had a statistically lower PLR when compared to the HCG (-) group ( p =0.02). In the ROC analysis, PLR was significant in predicting positive HCG ( p =0.028). However, when we added other factors to the model, only age and MII oocyte count were successful in predicting pregnancy outcomes in a logistic regression analysis. Conclusion: According our results, inflammatory hematological markers were not effective in predicting IVF success.

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Section: Discussionmentioning

confidence: 99%

The Role of Inflammatory Hematological Markers in Predicting IVF Success

Özgü-Erdinç¹,

Çoşkun²,

Yorgancı³

et al. 2020

JBRA

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“…[8][9][10][11][12] However, the results are contradictory as there are numerous studies that reported no difference in these parameters. [10,[14][15][16][17] Similarly, there are contradictory results with respect to WBC and red blood cells. [13,16] Among platelet indices only PCT was found to be increased significantly in GDM patients; however, in regression analysis this association disappeared indicating that PCT is not an independently associated factor.…”

Section: Discussionmentioning

confidence: 99%

“…[10,[14][15][16][17] Similarly, there are contradictory results with respect to WBC and red blood cells. [13,16] Among platelet indices only PCT was found to be increased significantly in GDM patients; however, in regression analysis this association disappeared indicating that PCT is not an independently associated factor. PMI was also assessed which had not been assessed in GDM before.…”

Section: Discussionmentioning

confidence: 99%

“…However, in some other studies these results could not be confirmed. [10,[14][15][16][17] CBC is a convenient and inexpensive test that provides important information. In addition to the above parameters that had been assessed in GDM, immature granulocytes, platelet mass (platelet count x MPV/1000), nucleated red blood cells (NRBC) and red cell distribution width (RDW) are also components of CBC that have been correlated with inflammation and blood glucose.…”

Section: Introductionmentioning

confidence: 99%

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Basit Bir Tam Kan Sayımı Gestastonel Diyabetes Mellitusu Öngörebilir Mi?

Aytan

Babuş

Sakarya

et al. 2020

Journal of Contemporary Medicine

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To assess the role of simple complete blood count (CBC) in prediction of gestational diabetes (GDM). Material and Method: Pregnant women screened for GDM in 24-28 gestational weeks with a 75g-OGTT between January 2018-January 2020 were retrospectively investigated. Patients with a known systemic disease, using aspirin, low-molecular-weight heparin and steroids were excluded. A total of 359 patients (81 with GDM and 278 controls) were enrolled. The assessed parameters in CBC were hemoglobin, hematocrit, red blood cells, mean corpuscular volume, mean corpuscular hemoglobin concentration, white blood cells (including neutrophils, lymphocytes, monocytes, eosinophils, basophils), platelets, platelet distribution width (PDW), mean platelet volume (MPV), red cell distribution width (RDW), nucleated red blood cell (NRBC), NRBC percentage, plateletcrit (PCT), platelet large cell ratio (P-LCR), immature granulocytes (IG) and IG percentage. Platelet mass index (PMI), neutrophil-tolymphocyte ratios (NLR) and platelet-to-lymphocyte ratios (PLR) were calculated. These parameters were compared between GDM patients and controls. Regression analysis was performed with the parameters that were significantly correlated with GDM. ROC curve analysis was done in order to find cutoff values. Results: RBC, WBC (all subtypes including immature granulocytes), platelet indices including PMI, NLR and PLR were all similar. Only RDW and NRBC were found to be significantly increased in GDM patients and came out to be independent predictors of GDM with maternal age and screening week. Conclusion: These findings suggest that women with GDM may be accompanied with increased RDW and NRBC levels which seem to be independent predictors of this disease and these parameters may be used to monitor and evaluate the development of GDM.

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“…Elevated serum hs-CRP is an independent risk factor for cardiovascular disease. However, the relationship between inflammatory response and GDM remains unclear [6].…”

Section: Introductionmentioning

confidence: 99%

Changes of Serum Sex Hormone-Binding Globulin, Homocysteine, and Hypersensitive CRP Levels during Pregnancy and Their Relationship with Gestational Diabetes Mellitus

Liu

Huang

Tang

et al. 2021

Gynecol Obstet Invest

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Background: Inflammatory response state is related to the pathogenesis of gestational diabetes mellitus (GDM). Objective: To investigate the changes of serum sex hormone-binding globulin (SHBG), homocysteine (Hcy), and hypersensitive CRP (hs-CRP) levels during pregnancy and their relationship with GDM. Methods: The nested case-control study method was used. Sixty nonobese single pregnant women diagnosed with GDM were divided into the GDM group (GDM, n = 60), together with another 60 pregnant women with normal glucose tolerance who were matched in the same period and divided into the control group (control, n = 60). The serum Hcy, hs-CRP, and SHBG levels were measured. Results: The serum levels of Hcy and hs-CRP were significantly higher in the GDM group compared with the control group, and serum levels of SHBG was significantly lower in the GDM group compared with the control group at different stages of pregnancy. The serum levels of Hcy and hs-CRP in pregnant women increased with the increase of gestational age, and serum levels of SHBG decreased with the increase of gestational age. Increased Hcy and hs-CRP levels in the second trimester and decreased SHBG levels in the first trimester were related to GDM. The odds ratio (OR) and 95% confidence interval (CI) were as follows: OR: 4.5, 95% CI: 1.5–13.0; OR: 4.2, 95% CI: 1.5–10.1; and OR: 0.4, 95% CI: 0.3–0.7, respectively. Conclusion: Increased Hcy and hs-CRP in the second trimester and decreased SHBG in the first trimester were independent predictors of GDM, which provides a new idea for early prevention and treatment of GDM.

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A Study of Inflammatory Markers in Gestational Diabetes Mellitus

Cited by 19 publications

References 21 publications

The Role of Inflammatory Hematological Markers in Predicting IVF Success

The Role of Inflammatory Hematological Markers in Predicting IVF Success

Basit Bir Tam Kan Sayımı Gestastonel Diyabetes Mellitusu Öngörebilir Mi?

Changes of Serum Sex Hormone-Binding Globulin, Homocysteine, and Hypersensitive CRP Levels during Pregnancy and Their Relationship with Gestational Diabetes Mellitus

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