The importance of redox state in liver damage

In vivo hepatoprotective activity of the aqueous extract of Artemisia absinthium L. against chemically and immunologically induced liver injuries in mice

“…Namely, the liver is a principal organ involved in generation of reactive oxygen species (ROS) induced by drugs and toxic chemicals. Excessive production of free radicals results in oxidative stress, which leads to a damage of important macromolecules (Cesaratto et al, 2004). Lipid peroxidation, the major free radical reaction in cellular membranes, can cause extensive oxidative damage to cells and tissues.…”

Antidiabetic drug metformin alleviates endotoxin-induced fulminant liver injury in mice

“…To further evaluate the degree of liver injury, lipid peroxidation in liver tissue was determined by measuring the level of MDA, which is an end product of lipid peroxidation in liver damage [18]. As shown in Fig.…”

Naringenin-Loaded Nanoparticles Improve the Physicochemical Properties and the Hepatoprotective Effects of Naringenin in Orally-Administered Rats with CCl4-Induced Acute Liver Failure

“…Oxidative stress contributes a decisive generating factor in the pathogenesis of acute and chronic liver diseases (1)(2)(3). Acute liver failure (ALF) is one of the acute liver diseases that can be caused by viruses, drugs, and toxins, and can lead to the development of hepatic encephalopathy and severe impairment of liver function (4).…”