Naringenin-Loaded Nanoparticles Improve the Physicochemical Properties and the Hepatoprotective Effects of Naringenin in Orally-Administered Rats with CCl4-Induced Acute Liver Failure

Yen, Feng Lin; Wu, Tung Ying; Lin, Liang; Cham, Thau-Ming; Lin, Chih‐Hsueh

doi:10.1007/s11095-008-9791-0

Cited by 197 publications

(90 citation statements)

References 61 publications

(66 reference statements)

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“…25 As listed in Table 1, the organic phase consisted of various ratios of EE with 20 mg of 734THIF in 10 mL of ethanol, which was quickly injected into 40 mL of aqueous phase containing various ratios of PVA. During the injection process, the mixed solution was homogenized at 22,000 rpm for 5 minutes.…”

Section: Preparation Of Ee-pva-loaded 734thif Nanoparticles (734n) Anmentioning

confidence: 99%

Design of acid-responsive polymeric nanoparticles for 7,3',4'-trihydroxyisoflavone topical administration

Huang¹,

Hu²,

Lee³

et al. 2016

IJN

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7,3′,4′-Trihydroxyisoflavone (734THIF) is a secondary metabolite of daidzein and has been recently found to possess antioxidant, melanin inhibition, and skin cancer chemopreventive activities. However, the poor water solubility of 734THIF impedes its absorption and skin penetration and, therefore, limits its pharmacological effects when applied topically to the skin. We seek to use the nanoprecipitation method to prepare optimal eudragit E100 (EE)–polyvinyl alcohol (PVA)-loaded 734THIF nanoparticles (734N) to improve its physicochemical properties and thereby increase its water solubility, skin penetration, and biological activities. EE–PVA-loaded 734THIF nanoparticles (734N) were prepared, and their morphology and particle size were evaluated using a particle size analyzer and by electron microscopy. The drug loading and encapsulation efficiencies and in vitro solubility were determined using high-performance liquid chromatography. Hydrogen-bond formation was evaluated by 1 H-nuclear magnetic resonance and Fourier transform infrared spectroscopy, and crystalline-to-amorphous transformation was determined by differential scanning calorimetry and X-ray diffractometry. In vitro skin penetration was analyzed using fresh pig skin mounted on Franz diffusion cells, and cytotoxicity against human keratinocyte HaCaT cells was evaluated using the MTT assay. Antioxidant activity was determined by 2,2-diphenyl-1-picrylhydrazyl-free radical scavenging ability. EE–PVA-loaded 734THIF nanoparticles showed good drug loading and encapsulation efficiencies and were characterized by improved physicochemical properties, including reduction in particle size, amorphous transformation, and intermolecular hydrogen-bond formation. This is associated with increased water solubility and enhanced in vitro skin penetration, with no cytotoxicity toward HaCaT cells. In addition, 734THIF nanoparticles retained their antioxidant activity. In conclusion, 734THIF nanoparticles are characterized by improved physicochemical properties, increased water solubility, and enhanced skin penetration, and these may have potential use in the future as a topical delivery formulation for the treatment of skin diseases.

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Section: Preparation Of Ee-pva-loaded 734thif Nanoparticles (734n) Anmentioning

confidence: 99%

Design of acid-responsive polymeric nanoparticles for 7,3',4'-trihydroxyisoflavone topical administration

Huang¹,

Hu²,

Lee³

et al. 2016

IJN

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“…This resulted into precipitation of polymer along with drug entrapped into the polymer matrix, to give instantaneous formation of NP with drug distributed into the polymer matrix [8]. The nanoprecipitation technique was relatively straightforward and rapid, and offered reproducible particle size with a narrow distribution [9].…”

Section: Introductionmentioning

confidence: 99%

Critical Process Parameters Evaluation of Modified Nanoprecipitation Method on Lomustine Nanoparticles and Cytostatic Activity Study on L132 Human Cancer Cell Line

Mehrotra¹

2012

J Nanomedic Nanotechnol

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This work was focused on identification and evaluation of process parameters of modified nanoprecipitation method, for fabrication of lomustine nanoparticles, with the aim of reducing cancer cell viability at low concentration of lomustine. The parameters controlling particle size, mostly in nanosize, were solvent/nonsolvent composition and emulsification speed of homogenizer along with aqueous phase volume. This controlled particle size is below 250 nm. The stabilizer concentration controlled particle size is within 68 nm ± 0.89 to 137 ± 0.94 nm with PDI 0.06 ± 0.008 to 0.25 ± 0.001. But, the stabilizer addition mode showed more uniform size distribution with PDI 0.085 ± 0.004. Entrapment efficiency was maintained well above 47 ± 0.23%. The drug release pattern was monophasic with controlled release over 24 hrs. In the method used, drug content was affected by ratio of polymer to drug to organic solvent, as well as homogenization speed and time. Percentage viable cells of L132 human lung cancer cell line remained, were only 5% at 100 µg/ml lomustine equivalent PLA nanoparticles. ethanol as a cosolvent, homogenization speed and time were evaluated affecting the particle size, encapsulation efficiency and in vitro drug release.

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“…It is anticipated that the effective and valuable relevance of the natural products and herbal remedies being applied with the nano carrier will enhance the significance of existing drug delivery systems. [11,12,19,31] …”

Section: Resultsmentioning

confidence: 99%

“…Quinine extracted from the cinchona tree (Cinchona officinalis) is used to treat malaria, and from willow bark aspirin was isolated is used for the treatment of fever. [19] Most of the plants and formulations (e.g. ,colchicine, curcumin, triphala, pomegranate, guggalosterone, sariva, etc.)…”

Section: Review Articlementioning

confidence: 99%

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Tapadiya¹

2017

IJGP

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Natural herbs are moving from fringe to mainstream use with a increase number of population-seeking remedies and health approaches free from hazardous side effects caused by laboratory synthesize chemicals. Recently, focus has been given to utilize eco-friendly and bio-friendly natural-based products for the prevention and cure of diseases. It is documented that 80% of the world's population has belief in natural medicine, particularly plant-based drugs for their primary healthcare. Herbal drug generally introduce in the market in traditional dosage form but now different scientific approaches are being developed these days to deliver herbal medicines due to their poor rate of absorption and target specific approach. Novel drug delivery systems including nanoparticles have been developed for the effective delivery of herbal drugs. Nanoparticulate formulations such as liposomes, polymeric nanoparticles, microemulsions, proliposomes, and solid lipid nanoparticles present potential to deliver herbal medicines effectively. Because of nanotechnology, the use of herbal drug is greatly increased in recent years. In this article, we are try to elaborating the role of nanotechnology which increases the potential as well as sale of herbal drugs in global world.

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Naringenin-Loaded Nanoparticles Improve the Physicochemical Properties and the Hepatoprotective Effects of Naringenin in Orally-Administered Rats with CCl4-Induced Acute Liver Failure

Abstract: NARN effectively improved the release of NAR which resulted in more hepatoprotective effects mediated by its antioxidant and antiapoptotic properties. These observations also suggest that nanoformulation can improve the free drug's bioactivity on oral administration.

Cited by 197 publications

References 61 publications

Design of acid-responsive polymeric nanoparticles for 7,3',4'-trihydroxyisoflavone topical administration

Design of acid-responsive polymeric nanoparticles for 7,3',4'-trihydroxyisoflavone topical administration

Critical Process Parameters Evaluation of Modified Nanoprecipitation Method on Lomustine Nanoparticles and Cytostatic Activity Study on L132 Human Cancer Cell Line

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Naringenin-Loaded Nanoparticles Improve the Physicochemical Properties and the Hepatoprotective Effects of Naringenin in Orally-Administered Rats with CCl4-Induced Acute Liver Failure

Abstract: NARN effectively improved the release of NAR which resulted in more hepatoprotective effects mediated by its antioxidant and antiapoptotic properties. These observations also suggest that nanoformulation can improve the free drug's bioactivity on oral administration.

Cited by 197 publications

References 61 publications

Design of acid-responsive polymeric nanoparticles for 7,3&#39;,4&#39;-trihydroxyisoflavone topical administration

Design of acid-responsive polymeric nanoparticles for 7,3&#39;,4&#39;-trihydroxyisoflavone topical administration

Critical Process Parameters Evaluation of Modified Nanoprecipitation Method on Lomustine Nanoparticles and Cytostatic Activity Study on L132 Human Cancer Cell Line

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Design of acid-responsive polymeric nanoparticles for 7,3',4'-trihydroxyisoflavone topical administration

Design of acid-responsive polymeric nanoparticles for 7,3',4'-trihydroxyisoflavone topical administration