The Importance of Propolis in Combating COVID-19

Uçar, Meltem

doi:10.35206/jan.932050

Cited by 3 publications

References 48 publications

(50 reference statements)

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Role and the importance of green approach in biosynthesis of nanopropolis and effectiveness of propolis in the treatment of COVID-19 pandemic

Barsola

Saklani

Kumari

et al. 2023

Green Processing and Synthesis

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The most fascinating product of honeybee is propolis. It has an immense role in dentistry, dermatology, and otorhinolaryngology. The increased popularity of propolis as an important remedy is due to its constituents, which have anti-inflammatory, immunomodulatory, antihepatotoxic, anti-cancerous, antifungal, antioxidant, antidiabetic, and antiviral activities. The diverse biological and pharmacological activities of propolis have piqued the interest of many scientists. Many techniques like gas chromatography-mass spectrometry, chromatography, and spectroscopy are being used to identify different propolis constituents. Flavonoids, phenolic acids, and their esters are the most pharmacologically active molecules of propolis and are known to disrupt the replication machinery of the virus corroborating the anti-coronavirus activity of propolis. The main aim of this article is to provide an insight of the increasing theragnostic uses of propolis and its nanoparticles, including their chemical analysis, diverse biological activities, and the necessity for chemical standardization. In this review, we have focused at the promising effects of propolis, its optimization, and its liposomal formulation as a therapeutic intervention for COVID-19 and its accompanying comorbidities.

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Role and the importance of green approach in biosynthesis of nanopropolis and effectiveness of propolis in the treatment of COVID-19 pandemic

Barsola

Saklani

Kumari

et al. 2023

Green Processing and Synthesis

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Farklı Bitki Kaynaklı Anadolu Propolis Örneklerinin Kimyasal İçeriği ve Antimikrobial Aktivitelerinin Araştırılması

Sönmez

2023

Uludağ Arıcılık Dergisi

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The ethnopharmacological approach combined with chemical and biological methods can be a useful model in the field of pharmacology. One of these approaches, apitherapy, is the use of bee and hive products for therapeutic purposes. Propolis is among the best known of these bee products. The chemical composition of propolis varies according to the local or endemic flora, bee species, geographical origin and season. This study is to determine the antimicrobial activity differences between chestnut and polifloral origin propolis against various pathogenic bacterial species. First of all, the Liquid Chromatography-Mass Spectrometry (LC-MS/MS) method was used for the determination of bioactive components known to be responsible for antimicrobial activity. Folin-Ciocalteu method and colorimetric aluminum chloride assay were used to determine the total phenolic (TP) and flavonoid (TF) amounts. 19 different pathogenic microorganisms were selected to test the antimicrobial activity levels of propolis samples with agar well diffusion and minimum inhibitory concentration (MIC) methods. TP and TF values of chestnut propolis (71.06 mg GAE/mL-11.75 mg QE/mL) were significantly higher than polifloral sample (36.84 mg GAE/mL-7.04 mg QE/mL). Chrysin, a flavone derivative, was the most abundant compound in both samples. The MIC values of chestnut propolis ranged from 19.5 to 2500 µg/mL, while the MIC value of polifloral origin propolis was between 39.06 and 5000 µg/mL. The most susceptible strain was Mycobacterium smegmatis for both samples with different concentration. Notably, it was observed that the botanical origins affect the chemical composition of propolis, and this situation can also be effect antibacterial and antifungal activity in respective propolis because of the different amount and diversity of bioactive compounds. Consequently, chestnut propolis is a promising candidate for drug discovery that can be used to treat some infectious diseases, including resistant bacteria.

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Anti-metastasis After Bee Venom and Melittin by Upregulation of BRMS1 and DRG1 Genes, With Downregulation of WNT7B in Breast Cancer Cells

Celik

2024

Preprint

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Breast cancer is one of the common cancers in women around the world, and metastasis potential of cancer is the main shortcoming for a high rate of survival. Apitherapy as an alternative medicine is promised to deal with cancer. Bee venom and its major component, melittin, are known to be effective for cytotoxicity in cancer cells. In this study, the expression profiles of three anti-metastatic genes including _BRMS1_,_ DRG1_ and _KAI1/CD82 _were revealed for the first time after bee venom and melittin treatment, and two pro-metastatic genes including _EGFR_ and _WNT7B_ in metastatic breast cancer cells (MDA-MB-231) were also examined while comparing to normal breast epithelial cells (MCF10A). Selective cytotoxicity of bee venom and melittin were higher compared to cisplatin. Melittin at 0.5 µg/ml was effective at 24h for anti-metastatic function whereas 4 µg/ml was significant in treatments with bee venom or cisplatin. Melittin induced overexpression of _BRMS1_ and _DRG1_, however bee venom induced _DRG1_ and _KAI1/CD82 _expression in breast cancer cells. _WNT7B_ was downregulated in bee venom-treated breast cancer cells. These results suggest that both bee venom and melittin may act via upregulation of some anti-metastatic genes (_BRMS1_, _DRG1_ and _KAI1/CD82)_, and down-regulation of a pro-metastatic gene, _WNT7B_.

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The Importance of Propolis in Combating COVID-19

Cited by 3 publications

References 48 publications

Role and the importance of green approach in biosynthesis of nanopropolis and effectiveness of propolis in the treatment of COVID-19 pandemic

Role and the importance of green approach in biosynthesis of nanopropolis and effectiveness of propolis in the treatment of COVID-19 pandemic

Farklı Bitki Kaynaklı Anadolu Propolis Örneklerinin Kimyasal İçeriği ve Antimikrobial Aktivitelerinin Araştırılması

Anti-metastasis After Bee Venom and Melittin by Upregulation of BRMS1 and DRG1 Genes, With Downregulation of WNT7B in Breast Cancer Cells

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