The importance of microjet vs shock wave formation in sonophoresis

Wolloch, Lior; Kost, Joseph

doi:10.1016/j.jconrel.2010.07.106

Cited by 74 publications

(35 citation statements)

References 35 publications

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“…The power generated by the micro-jets transmits downward and is focused on a tiny spot of skin surface. These micro-jets can severely disrupt the SC layer and have been confirmed as the main contribution to the permeability increment [94]. The mechanism of forming micro-jets is shown in Fig.…”

Section: Acoustic Cavitation In Low Frequency Sonophoresismentioning

confidence: 87%

Potential of combined ultrasound and microneedles for enhanced transdermal drug permeation: A review

Han

Das

2015

European Journal of Pharmaceutics and Biopharmaceutics

128

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Citation: HAN, T. and DAS, D.B., 2015. Potential of combined ultrasound and microneedles for enhanced transdermal drug permeation: a review. European Journal of Pharmaceutics and Biopharmaceutics,89, Additional Information:• NOTICE: this is the author's version of a work that was accepted for publication in European Journal of Pharmaceutics and Biopharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive ver- have been developed to overcome the resistance of the stratum corneum to molecular 10 diffusion. In particular, researchers have started to consider the possibility of combining the 11 TDD technologies in order to have further increase in drug permeability. Microneedles (MNs) 12 and ultrasound are both promising technologies. They achieve enhancement in drug 13 permeation via different mechanisms and therefore give a good potential for combining with 14 each other. This review will focus on discussing the potential of this combinational technique 15 along with other important issues, e.g., the mechanisms of ultrasound and MNs as it is these 16 mechanisms which are coupled via the two systems (i.e. MNs and ultrasound). We discuss 17 the possible ways to achieve this combination as well as how this combination would 18 increase the permeability. Some of the undeveloped (weaker) research areas of MNs and 19 sonophoresis are also discussed in order to understand the true potential of combining the two 20 technologies when they are developed further in the future. We propose several hypothetical 21 combinations based on the possible mechanisms involved in MNs and ultrasound. 22Furthermore, we carry out a cluster analysis by which we determine the significance of this 23Page 2 of 54 combinational method in comparison with some other selected combinational methods for 24 TDD (e.g., MNs and iontophoresis). Using a time series analysis tool (ARIMA model), the 25 current trend and the future development of combined MNs and ultrasound are also analysed. 26Overall, the review in this paper indicates that combining MNs and ultrasound is a promising 27 TDD method for the future. 28

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Section: Acoustic Cavitation In Low Frequency Sonophoresismentioning

confidence: 87%

Potential of combined ultrasound and microneedles for enhanced transdermal drug permeation: A review

Han

Das

2015

European Journal of Pharmaceutics and Biopharmaceutics

128

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“…Commonly used ultrasound duty cycles are 10% (eg, 0.1 second on and 0.9 second off), 58,59 50% (eg, 5 seconds on and 5 seconds off), 36,60,61 or continuous application. 62,63 The horn-to-skin distances used range from the ultrasound horn being in direct contact with the skin (zero distance) to 4.0 cm.…”

Section: Clinical Application Of Urdds Transdermal Drug Deliverymentioning

confidence: 99%

Potential and problems in ultrasound-responsive drug delivery systems

Zhao¹,

Du²,

Lu³

et al. 2013

IJN

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Abstract:Ultrasound is an important local stimulus for triggering drug release at the target tissue. Ultrasound-responsive drug delivery systems (URDDS) have become an important research focus in targeted therapy. URDDS include many different formulations, such as microbubbles, nanobubbles, nanodroplets, liposomes, emulsions, and micelles. Drugs that can be loaded into URDDS include small molecules, biomacromolecules, and inorganic substances. Fields of clinical application include anticancer therapy, treatment of ischemic myocardium, induction of an immune response, cartilage tissue engineering, transdermal drug delivery, treatment of Huntington's disease, thrombolysis, and disruption of the blood-brain barrier. This review focuses on recent advances in URDDS, and discusses their formulations, clinical application, and problems, as well as a perspective on their potential use in the future.

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“…Both of these methods forms a strong stirring affect and mixes the two immiscible fluids. Therefore, the ultrasonic technique would be used beneficially to prepare water-diesel emulsions [11][12][13][14]. The mechanical stirrer machine, the mostly used emulsifying machine, stirs up the mixture of continuous and dispersed phase with the presence of surfactant [15].…”

Section: Introductionmentioning

confidence: 99%

The study of stability, combustion characteristics and performance of water in diesel emulsion fuel

et al. 2016

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Abstract.A single cylinder diesel engine study of water in diesel emulsions was conducted to investigate the stability effect of emulsion fuel on three different fuel blends and the water emulsification effect on the engine performance. Emulsified fuels contained 2% of surfactant including Span 80 Tween 80 and tested 10 HLB number. The blends also varied of 5%, 10% and 15% of water in diesel ratios namely as BSW5, BSW10 and BSW15. The fuel blends performance was tested using a single cylinder, direct injection diesel engine, operating at 1860 rpm. The results on stability reveal that high shear homogenizer yields more stability on emulsion fuel than mechanical stirrer and ultrasonic water bath. The engine performance results show that the ignition delay and peak pressure increase with the increment of water percentage up to 15%. However, the results indicate the increment of water percentage is also shows a significant decrease in engine power.

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The importance of microjet vs shock wave formation in sonophoresis

Cited by 74 publications

References 35 publications

Potential of combined ultrasound and microneedles for enhanced transdermal drug permeation: A review

Potential of combined ultrasound and microneedles for enhanced transdermal drug permeation: A review

Potential and problems in ultrasound-responsive drug delivery systems

The study of stability, combustion characteristics and performance of water in diesel emulsion fuel

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