The importance of getting it right the first time

Abstract

TLNJ is supported by unrestricted academic grants from the Sigrid Juselius Foundation, the State funding for university-level health research (Helsinki University Hospital), the Social Insurance Institution of Finland (KELA), and the Academy of Finland. These organizations had no involvement in the writing of the manuscript or its intellectual content.

Proteomic Analyses of Autologous Chondrocyte Implantation Plasma Highlight Cartilage Acidic Protein 1 as a Candidate for Preclinical Screening

“…Thus, preclinical screening could help to ensure that these patients can be stratified for alternative therapeutic interventions more quickly to prevent the worsening of symptoms and osteoarthritis (OA) progression, in line with the ''getting it right first time'' scheme. 18 We previously demonstrated that protein differences exist within the synovial fluid of those who either show clinical improvement after ACI (responders) or not (nonresponders). 11,12,34 Despite this, there remains a need to identify biomarkers that have the capacity to predict clinical outcome after ACI and other orthopaedic interventions and can be detected within the blood.…”

“…Thus, preclinical screening could help to ensure that these patients can be stratified for alternative therapeutic interventions more quickly to prevent the worsening of symptoms and osteoarthritis (OA) progression, in line with the “getting it right first time” scheme. 18 …”