The importance of esophageal function tests in patients with Barrett’s esophagus

Маев, И. В.; Zayratyants, O. V.; Kucheryavy, Yu.A.; Barkalova, E. V.; Андреев, Д. Н.; Movtaeva, P.R.; Shaburov, R. I.; Ovsepyan, M. A.

doi:10.17116/dokgastro2020901141

Dok. gastroenterol.

2020

DOI: 10.17116/dokgastro2020901141

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The importance of esophageal function tests in patients with Barrett’s esophagus

И. В. Маев¹,

O. V. Zayratyants²,

Yu.A. Kucheryavy³

et al.

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Cited by 4 publications

(1 citation statement)

References 32 publications

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“…ГЭРБ, ФД и СРК являются одними из наиболее распространенных нозологических единиц в детской гастроэнтерологической практике [30]. Наиболее распространенными вариантами таких комбинаций являются синдром перекреста ГЭРБ и ФД, а также СРК и ФД [31,32].…”

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Оverlap-syndrome in pediatric practice

Chernenkov

Glushakov

Glushakova

et al. 2023

jour

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The problem of combined pathology in childhood has an important medical and social aspect. To date, aspects of the pathogenesis of the overlap syndrome are being considered and studied. Despite reliable data on the factors in the development of overlap syndrome in clinical practice, the eff ectiveness of diagnosis and treatment is still low. This review summarizes the current scientifi c data from epidemiological studies of various types of overlap syndrome, therapeutic approaches, and also analyzes a rare clinical case in pediatrics.The purpose of the review is to present an analysis of current literature data on the prevalence of overlap syndrome in pediatric practice.

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Оverlap-syndrome in pediatric practice

Chernenkov

Glushakov

Glushakova

et al. 2023

jour

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Asymptomatic Barrett’s Oesophagus-Complicated Gastroesophageal Reflux Disease at Ineffective Antisecretory Therapy

Barkalova

Пирогов

Andreev

et al. 2021

Rossijskij žurnal gastroènterologii, gepatologii, koloproktolog

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Aim. A clinical description of gastroesophageal reflux disease (GERD) complicated by Barrett’s oesophagus (BO) at inadequate antisecretory therapy and the assessment of functional tests in control of conservative treatment.Key points. A 63-yo patient with no complaints in a proton pump inhibitor (PPI) therapy was admitted for a follow-up examination for BO-complicated GERD using oesophagogastroduodenoscopy (OGDS) with biopsy, high-resolution oesophageal manometry and 24-h pH-impedance. Endoscopy revealed signs of BO (long segment C1M3), erosive reflux oesophagitis (grade B in Los Angeles classification). Non-contractile oesophagus in manometry. Antisecretory therapy was stated ineffective and subject to correction in 24-h pH-impedance.Conclusion. Asymptomatic BO-complicated GERD patients comprise a special cohort. The main challenge to prevent progression into oesophageal adenocarcinoma is an adequate personalised patient management leveraging the modern diagnostic techniques, control of antisecretory treatment and its correction a situ.

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Features of the Parameters of 24-Hours pH-Impedance and High-Resolution Esophageal Manometry in Patients with Barrett's Esophagus on Proton Pump Inhibitors

Маев

Bordin

Barkalova

et al. 2023

Rossijskij žurnal gastroènterologii, gepatologii, koloproktolog

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Аim: to identify predictors of insufficient effectiveness of proton pump inhibitors based on the evaluation of the results of 24-hour pH-impedance and high-resolution esophageal manometry in patients with Barrett's esophagus.Materials and methods. 52 patients with histologically confirmed Barrett's esophagus who are on therapy with proton pump inhibitors were examined. All patients underwent daily pH-impedance and high-resolution esophageal manometry.Results. According to daily pH-impedance, group 1 consisted of 37 patients who responded satisfactorily to antisecretory therapy, group 2 of 15 patients who demonstrated insufficient response to acid-suppressive therapy, 11 of whom had no clinical manifestations. The total number of reflux averaged 55 in group 1 and 106 in group 2. The average number of acid reflux in group 1 was 5.68, in group 2 — 48.5. The average number of non-acid reflux prevailed in patients of group 2 and averaged 58, in group 1 the indicator averaged 47. Evaluation of the results of high-resolution esophageal manometry showed that violations of the structure and function of the esophago-gastric junction were detected in 21 patients out of 52. Disorders of the motility of the thoracic esophagus were detected in 31 patients out of 52. When comparing the frequency of motor disorders from the thoracic esophagus in groups 1 and 2, no significant differences were obtained. However, significantly more frequent registration of violations of the structure and/or function of the esophago-gastric junction was found in the group with unsatisfactory effectiveness of proton pump inhibitors.Conclusion. In a number of patients with Barrett's esophagus, there is an insufficient effect of acid-suppressive therapy and at the same time an asymptomatic course of the disease, which may increase the risk of its progression. Predictors of insufficiently successful treatment of patients with Barrett's esophagus may be both insufficient pharmacological effect of proton pump inhibitors themselves, and motility disorders that cause the presence of non-acid reflux, decreased esophageal clearance, which in turn may cause the patient's symptoms to persist and adversely affect the condition of the esophageal mucosa.

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The importance of esophageal function tests in patients with Barrett’s esophagus

Cited by 4 publications

References 32 publications

Оverlap-syndrome in pediatric practice

Оverlap-syndrome in pediatric practice

Asymptomatic Barrett’s Oesophagus-Complicated Gastroesophageal Reflux Disease at Ineffective Antisecretory Therapy

Features of the Parameters of 24-Hours pH-Impedance and High-Resolution Esophageal Manometry in Patients with Barrett's Esophagus on Proton Pump Inhibitors

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