The importance of coenzyme Q10 and its ratio to cholesterol in the progress of chronic kidney diseases linked to non- -communicable diseases

Abstract

OBJECTIVES: The mortality of patients with chronic kidney diseases (CKD) increases with the decrease in glomerular fi ltration rate (eGFR). In the progress of CKD that is closely linked to non-communicable diseases (NCDs), the role of coenzyme Q 10 (CoQ 10) is not fully evaluated. We aimed to evaluate the importance of CoQ 10, CoQ 10 /cholesterol ratio, and oxidative stress in the progress of CKD. PATIENTS AND METHODS: The control group was constituted of 19 healthy subjects who volunteered to enrol in the study, CKD group consisted of 58 patients with CKD, of whom 54 had CKD combined with hypertension, 22 had CKD combined with hypertension and diabetes type 2 , and 18 had CKD combined with hypertension and statin therapy. We observed age, BMI, creatinine, uric acid, eGFR, hemoglobin, CRP, glucose, lipids fraction, and liver enzymes. Coenzyme Q 10-TOTAL (ubiquinol+ubiquinone) in platelets and plasma were determined using HPLC method with UV detection. Indexed of CoQ 10 /lipid fractions were evaluated. Oxidative stress was determined as thiobarbituric acid-reactive substances (TBARS). RESULTS: With increased stages of CKD, eGFR and CoQ 10 as well as its ratio to lipids were signifi cantly reduced while TBARS increased. CONCLUSION: We assume that lower endogenous CoQ 10 level may be one of the reasons of kidney dysfunction. CoQ 10 /lipids ratio and increase in oxidative stress can predict the progression of CKD in patients with arterial hypertension, diabetes mellitus and dyslipidemia (Tab. 2, Fig. 4, Ref. 49). Text in PDF www.elis.sk KEY WORDS: chronic kidney disease, non-communicable diseases, glomerular fi ltration, creatinine, coenzyme Q 10, oxidative stress, index of CoQ 10-TOTAL /lipids.

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