The importance of botanical treatments in traditional societies and challenges in developing countries

Kakooza‐Mwesige, Angelina

doi:10.1016/j.yebeh.2015.06.017

Cited by 25 publications

(19 citation statements)

References 104 publications

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“…It remains unclear how many of such potential remedies actually make it into clinical trials and eventually making part of the AED list. More research in this area, applying strict research methodology with uniform herbal combinations, as well as clinical studies with selected standardized botanical extracts are urgently needed to determine which is most efficacious [ 1 , 11 ]. As Sucher and Carles [ 1 ] put it, “it is to the detriment of patients and progress if drug development efforts ignore the potential of plant-derived compounds”.…”

Section: Discussionmentioning

confidence: 99%

“…Herbal medicine plays a very important role in meeting the primary health care needs of the population, with Africa and Asia being the continents with most of the users [ 10 ]. Some medicinal plants have shown potential as new, safe treatment options [ 11 , 12 ]. Although many of them have traditionally been used as sedative and antiepileptic agent, there is still lack of controlled experimental reports on therapeutic use [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Recent Advances in Antiepileptic Herbal Medicine

Manchishi

2017

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Background:Epilepsy is one of the most common neurological disorders worldwide, with about 80 percent of cases thought to be in developing nations where it is mostly linked to superstition. The limited supply, high cost as well as low efficacy and adverse side effects of antiepileptic drugs (AEDs) is a matter of major concern. Herbal medicine has always been traditionally part of treatment of epilepsy. Herbal medicines are generally well tolerated, with fewer side effects.Method:To highlight some herbal extracts that have been studied for their anticonvulsant activity in animal models, literature search from PubMed and Science Direct, was performed. The keywords for the search consisted of combinations of the following terms: Herbal antiepileptic and/or anticonvulsant, botanicals + epilepsy. Literature published in the last five years was considered.Results:Eighteen (18) anticonvulsant herbal agents are reported and discussed. Experiments mostly consisted of phenotypic screens in rodents, with little diversity in screening methods. In most experiments, the tested extracts prolonged the time to onset of seizures and decreased their duration. Most experimenters implicate potentiation of GABAergic activity as the mode of action of the extracts, even though some experimenters did not fully characterise the bioactive chemical composition of their extracts.Conclusion:Potential herbal remedies have shown positive results in animal models. It remains unclear how many make it into clinical trials and eventually making part of the AED list. More rigorous research, applying strict research methodology with uniform herbal combinations, as well as clinical studies are urgently needed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recent Advances in Antiepileptic Herbal Medicine

Manchishi

2017

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“…To help move this field forward, recent publications have synthesized a vast amount of preclinical and clinical information concerning botanicals (often from journals and other sources not readily available to Western researchers), and authors often provide the information in the contexts of both the associated traditional medical system as well as modern medical bioscience (1, 13, 15). For example, Xiao et al (1) started their review by describing the TCM classification of epilepsy and how the principles of TCM are applied to patients in combining herbs with other treatment modalities, such as acupuncture, massage, diet, and therapeutic exercise.…”

Section: Example Of Traditional Chinese Medicinementioning

confidence: 99%

Translating Nature to Nurture: Back to the Future for “New” Epilepsy Therapies

Schachter

2015

Epilepsy Curr

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An emerging strategy for finding new epilepsy therapies is focused on botanicals (as illustrated by recent attention to medical marijuana), given their centuries-old traditions of use in treatment of convulsive seizures, contemporary anecdotal reports of efficacy in persons with epilepsy, and identification of underlying mechanisms of action that are relevant to epilepsy. Hundreds of plant extracts have been found to block seizures in acute animal seizure models, with actions that include effects on GABA receptors and voltage-gated ion channels as well as anti-inflammatory and neuroprotective effects. While existing published clinical studies of botanicals and seizure control are generally of inadequate quality to determine safety and efficacy, recent developments at the FDA may encourage sponsors to develop and commercialize botanicals for epilepsy.

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“…In this context, non-pharmacological therapy related to traditional, magical, and/or religious treatments also stands out. For example, many studies showed flora resources as the non-pharmacological treatment of convulsive disorders in traditional communities [4,5]. Also, the association of convulsive crises with hidden or bad influences permeates several populations' imagination, especially when considering traditional or culturally different communities [6].…”

Section: Introductionmentioning

confidence: 99%

Concepts, Beliefs, and Traditional Treatment for Childhood Seizures in a Quilombola Community in Northeastern Brazil: Analysis by the Discourse of the Collective Speech

Beltrão

Carneiro

Delmondes

et al. 2021

IJERPH

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Background: Non-pharmacological therapy related to traditional, magical, and/or religious treatments for managing recurrent and non-recurrent seizures in children persists in several traditional communities. The research aims to investigate the concepts, beliefs, and types of traditional treatments used for cases of seizures in children reported by residents of a quilombola community. Methods: The research took place in the quilombo community Sítio Arruda, Ceará, northeastern Brazil. The study population consisted of 19 participants, including healers, prayers, and midwives. Applied a socioeconomic form and a semi-structured interview script. For data analysis, the Discourse of the Collective Speech (DCS) technique was used. Results: For the questions asked, a total of 14 central ideas were found. The most prevalent was seizure is the most common type of disease in children (50.0%); The seizure occurs because of the fever (42.0%); In the community, we treat and prevent seizures with the use of plants (63.2%). Conclusions: The present study’s results addressed relevant issues that include valuing and understanding the traditional knowledge of the community, access to health services, and the need for clarification actions about seizures.

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The importance of botanical treatments in traditional societies and challenges in developing countries

Cited by 25 publications

References 104 publications

Recent Advances in Antiepileptic Herbal Medicine

Recent Advances in Antiepileptic Herbal Medicine

Translating Nature to Nurture: Back to the Future for “New” Epilepsy Therapies

Concepts, Beliefs, and Traditional Treatment for Childhood Seizures in a Quilombola Community in Northeastern Brazil: Analysis by the Discourse of the Collective Speech

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