The implications of the purinergic signaling throughout pregnancy

Abstract

Purinergic signaling is a necessary mechanism to trigger or even amplify cell communication. Its ligands, notably adenosine triphosphate (ATP) and adenosine, modulate specific membrane-bound receptors in virtually all human cells. Regardless of the stage of the pregnancy, cellular communication between maternal, placental, and fetal cells is the paramount mechanism to sustain its optimal status. In this review, we describe the crucial role of purinergic signaling on the regulation of the maternal-fetal trophic exchanges, immune control, and endocrine exchanges throughout pregnancy. The nature of the modulation of both ATP and adenosine on the embryo-maternal interface, going through placental invasion until birth delivery depends on the general maternal-fetal health state and consequently on the selective activation of their specific receptors. In addition, an increasing number of studies have been demonstrating the pivotal role of ATP and adenosine in modulating deleterious effects of suboptimal conditions of pregnancy. Here, we discuss the role of purinergic signaling on the balance that coordinates the embryomaternal exchanges and a promising therapeutic venue in the context of pregnancy disorders.

Altered purinergic signaling in women undergoing cardiac surgery under cardiopulmonary bypass

“…[51] Furthermore, increased CD73 and A2B levels in patients with pre-eclampsia has been associated with brosis. [53] The decrease in CD39 and adenosine receptors has been shown to be associated with heart failure and altered response to ischemia and reperfusion injury. [17,25] Our mice, with simulated post-menopause via high-fat diet and ovariectomy, complement the patient ndings of increased purinergic dysfunction, oxidative stress, and cardiac dysfunction.…”