Abstract:Despite recent advances in cardiac surgery, adverse outcomes remain more prevalent in females as compared to males. Our study aimed to further understand whether purinergic signaling plays a role in the discrepancy in outcomes of females presenting for cardiac surgery. Right atrial tissue was harvested from 80 patients undergoing cardiac surgery before and after and cardiopulmonary bypass (CPB). Human tissue experimentation was complemented by experiments in 40 mice subject to a high fat diet and ovariectomy. … Show more
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