The impairment of continuous malnutrition on larval fish swimming performance at the mouth-opening stage

Fan, Xiaoteng; Wang, Luanjin; Wei, Xuefeng; Zhang, Jia; Su, Xiaoyue; Cui, Ling; Wang, Zaizhao

doi:10.1016/j.aquaculture.2021.737053

Cited by 12 publications

(4 citation statements)

References 49 publications

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“…In conclusion, a low-quality diet significantly reduced sperm midpiece length, but did not impact the length of other sperm components (head, flagellum, total) or the proportion of normal sperm. The significant shortening in sperm midpiece is consistent with emerging evidence of other taxa, and the known plasticity of mitochondrial structure and function in other cell types in response to altered diet ( Zhang et al, 2020 ; Fan et al, 2021 ). We found that sperm velocity and proportion of motile sperm did not differ between dietary treatment groups but significantly decreased over the course of the experiment (in both experimental and control birds) by roughly 25%.…”

Section: Discussionsupporting

confidence: 84%

“…In the present study, midpiece shortening for the LQ group may mean there is less mitochondrial material in these sperm ( Knief et al, 2019 ; but see Mendonca et al, 2018 ), potentially reducing ATP availability ( Rowe et al, 2013 ; but see Bennison et al, 2016 ). Mitochondria in other cell types are known to regulate their density, size and activity in response to cellular conditions ( Rambold et al, 2011 ; Liao et al, 2016 ; Alcántar-Fernández et al, 2019 ; Bañuls et al, 2019 ), including reducing mitochondrial quantity in response to malnutrition ( Park et al, 2003 ; Zhang et al, 2020 ; Fan et al, 2021 ). Closely regulating mitochondria depending on nutrient availability and energy demand may be important to minimise oxidative stress, which sperm are particularly at risk of ( Tomášek et al, 2017 ; Helfenstein et al, 2010 ; Friesen et al, 2019 , 2020 ).…”

Section: Discussionmentioning

confidence: 99%

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The impact of diet quality on the velocity, morphology and normality of sperm in the zebra finch Taeniopygia guttata

McDiarmid

Hurley

Mesurier

et al. 2022

Journal of Experimental Biology

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Sperm traits can influence fertilisation success, but there is still much we do not understand about sperm condition dependence, that is, how much sperm traits depend on the male's energy acquisition and allocation. This is especially pronounced in avian taxa, despite extensive observational studies and sampling in wild populations. In this study we collected sperm samples before and after experimentally reducing diet quality of wild-derived captive zebra finches in small mixed-sex groups, which we compared to individuals on a control diet. We measured the length of sperm components (head, midpiece, flagellum and total sperm length), the proportion of sperm with normal morphology, the proportion of sperm that were progressively motile, and swimming velocity (curvilinear velocity; VCL). The only sperm trait we found to be impacted by reduced diet quality was a significant decrease in sperm midpiece length. This is consistent with emerging evidence in other non-model systems, as well the fact that diet can alter mitochondrial density and structure in other tissue types. There was also a significant decrease in sperm velocity and the proportion of motile sperm over the course of the experiment for both experimental groups (i.e. unrelated to diet). That in the control group experienced this decrease in sperm velocity was marked by no change in any sperm morphological measure highlights the existence of other important determinants of sperm velocity in passerine birds, likely including variation in other components of the seminal fluid.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

The impact of diet quality on the velocity, morphology and normality of sperm in the zebra finch Taeniopygia guttata

McDiarmid

Hurley

Mesurier

et al. 2022

Journal of Experimental Biology

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“…As the fish swimming performance sensitively and plastically responds to environmental insults, 60 the impaired larval swimming capability indicates the potential detrimental effects on their fitness and population dynamics upon continuous DBP exposure. As the larval swimming capability is developed and adjusted to sensory, neural, and muscular systems, 61 and energy budget, 62 the proven mtDNA stress-mediated signaling pathway in energy disorder and innate immunity sheds light on the mechanisms underlying the toxic effects of phthalates. Consistently, the depressed ATP content and highly upregulated inflammation at zebrafish larvae suggest that there is a persistent risk of mitochondrial stress and mtDNA-mediated inflammatory responses to swimming defects throughout the lifetime.…”

Section: Discussionmentioning

confidence: 99%

Mitochondrial DNA Stress-Mediated Health Risk to Dibutyl Phthalate Contamination on Zebrafish (Danio rerio) at Early Life Stage

Fan,

Zhang,

Hou

et al. 2024

Environ. Sci. Technol.

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Plastics contaminations are found globally and fit the exposure profile of the planetary boundary threat. The plasticizer of dibutyl phthalate (DBP) leaching has occurred and poses a great threat to human health and the ecosystem for decades, and its toxic mechanism needs further comprehensive elucidation. In this study, environmentally relevant levels of DBP were used for exposure, and the developmental process, oxidative stress, mitochondrial ultrastructure and function, mitochondrial DNA (mtDNA) instability and release, and mtDNA-cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling pathway with inflammatory responses were measured in zebrafish at early life stage. Results showed that DBP exposure caused developmental impairments of heart rate, hatching rate, body length, and mortality in zebrafish embryo. Additionally, the elevated oxidative stress damaged mitochondrial ultrastructure and function and induced oxidative damage to the mtDNA with mutations and instability of replication, transcription, and DNA methylation. The stressed mtDNA leaked into the cytosol and activated the cGAS-STING signaling pathway and inflammation, which were ameliorated by co-treatment with DBP and mitochondrial reactive oxygen species (ROS) scavenger, inhibitors of cGAS or STING. Furthermore, the larval results suggest that DBP-induced mitochondrial toxicity of energy disorder and inflammation were involved in the developmental defects of impaired swimming capability. These results enhance the interpretation of mtDNA stress-mediated health risk to environmental contaminants and contribute to the scrutiny of mitochondrial toxicants.

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“…During starvation, the liver plays a central role in the maintenance of systemic energy homeostasis by mobilizing liver glycogen and adipose tissue (Power et al, 2000). The liver mobilizes the energy substances to regulate the bodily energy metabolism, thereby regulating the movement, predation, and escape from natural enemies (Fan et al, 2021;Wang et al, 2019). However, it is largely unknown whether the released sh can maintain a sustained balance of energy metabolism before adapting to natural environment.…”

Section: Introductionmentioning

confidence: 99%

Liver transcriptome analysis reveals the energy regulation and functional impairment of Onychosoma sima during starvation

Chen

Zhou

Lin

et al. 2023

Preprint

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Releasing juvenile fish into the resource-depleted waters, is regarded as an effective way to restore fishery resources. However, during this stage, released fish are most vulnerable to long-term food deprivation due to environmental changes and low adaptability. Therefore, research regarding the energy regulation of fish under starvation stress is crucial to the optimization of release strategies. In this study, we performed a comparative transcriptome analysis of the liver of Onychosoma sima subjected to starvation for 14 days. The results showed that, under long-term starvation, the liver regulated glucose homeostasis by activating the gluconeogenesis pathway. Meanwhile, the fatty acid metabolism pathway was activated to supply acetyl-coA to the TCA cycle pathway, thus increasing mitochondrial ATP production and maintaining the balance of energy metabolism. Nevertheless, the activation of energy metabolism could not completely compensate for the role of exogenous nutrients, as evidenced by the downregulation of many genes involved in antioxidant defenses (e.g., cat, gpx3, mgst1, and mgst2) and immune response (e.g., c3, cd22, trnfrsf14, and a2ml). The consequence is multiple metabolic disorder, and the body resistance weakened. In summary, our data reveal the effects of long-term starvation on the energy metabolism and defensive regulation of released fish, and these findings will provide a new theoretical basis for the optimization of artificial release.

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The impairment of continuous malnutrition on larval fish swimming performance at the mouth-opening stage

Cited by 12 publications

References 49 publications

The impact of diet quality on the velocity, morphology and normality of sperm in the zebra finch Taeniopygia guttata

The impact of diet quality on the velocity, morphology and normality of sperm in the zebra finch Taeniopygia guttata

Mitochondrial DNA Stress-Mediated Health Risk to Dibutyl Phthalate Contamination on Zebrafish (Danio rerio) at Early Life Stage

Liver transcriptome analysis reveals the energy regulation and functional impairment of Onychosoma sima during starvation

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