The impact on colostrum oxidative stress, cytokines, and immune cells composition after SARS-CoV-2 infection during pregnancy

Graciliano, Nayara Gomes; Tenório, Micaely C.S.; Fragoso, Marilene Brandão Tenório; Moura, Fabiana Andréa; Botelho, Rayane Martins; Tanabe, Eloiza; Borbely, Karen Steponavicius Cruz; Borbely, Alexandre Urban; Oliveira, Alane Cabral Menezes de; Goulart, Marília Oliveira Fonseca

doi:10.3389/fimmu.2022.1031248

Cited by 3 publications

(2 citation statements)

References 81 publications

(85 reference statements)

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“…Interleukin 5 in breast milk is partly responsible for regulating B cell development and activation through JAK-STAT, Btk, and Ras/Raf-ERK signaling pathways, this pathways also lead to the maintenance of survival and function of B cell and eosinophil [28,29]. Recent studies reported that overexpression of IL-5 in vivo significantly increases the number of eosinophil and B cells.…”

Section: Discussionmentioning

confidence: 99%

The effect of Sauropus androgynus (L) Merr leaves decoction on primiparous colostrum immunomodulatory profile: study of Baliness traditional recepies for lactating mother

Kurniawan,

Winarsih,

Nurdiana

et al. 2024

Preprint

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Sauropus Androgynus (L) Merr is a herbal plant that is widely consumed by Baliness lactating women to increase breast milk production and reported have other health benefits including anti-inflammatory effects. Colostrum has essential nutrients to support the newborn's immune system including mucosal barrier maturation, especially immunoglobulin A (IgA). This study conducted to confirm colostrum IgA and IL-5 consentration shiftness during Baliness traditional recipes containing Sauropus Androgynus (L) Merr administration. Primiparous mothers between 22 and 30 years of age with uncomplicated atterm vaginal delivery were eligible to participate in the trial. We randomly assigned 34 women to traditional recepies containing Sauropus Androgynus (L) Merr treatment for 7 days (intervention group) and 32 were assigned as control group. Colostrum was isolated on the first day postpartum and the seventh day after consumption of Sauropus androgynus (L) Merr, followed by measurement of IgA and IL-5 levels using ELISA. A total of 6 women were unable to provide colostrum at 7 days and not regularly consumed treatment, so 30 women in the intervention group and 30 women in control group were included in teh analysis. Pre-post-test analysis was performed. Consumption of Sauropus Androgynus (L) Merr for 7 days significantly increased colostrum IgA concentration better than control (p=0.042) but not significantly reduce IL-5 colostrum concentration (p=0.119). Additionally, lowering IL-5 concentration signficantly correlated with elevating IgA colostrum after treated with Sauropus Androgynus (L) Merr (p=0.011). This finding corroborates scientific recommendations regarding another health benefit the Sauropus Androgynus (L) Merr as IgA colostrum booster. Further studies are needed to evaluate the effect of the consumption of Sauropus Androgynus (L) Merr on the IgA composition in mature milk.

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Section: Discussionmentioning

confidence: 99%

The effect of Sauropus androgynus (L) Merr leaves decoction on primiparous colostrum immunomodulatory profile: study of Baliness traditional recepies for lactating mother

Kurniawan,

Winarsih,

Nurdiana

et al. 2024

Preprint

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show abstract

“…22,23 Exposure to SARS-CoV-2 has been shown to influence human milk components, including antibodies, inflammatory mediators, cytokines and immune cells. [24][25][26][27][28][29][30][31][32][33] Nevertheless, our knowledge about the impact of maternal SARS-CoV-2 infection during pregnancy on HMEVs remains limited.…”

Section: Introductionmentioning

confidence: 99%

Prenatal SARS-CoV-2 infection alters postpartum human milk-derived extracellular vesicles

Cetinkaya

Zhang

Kuhnell

et al. 2023

Preprint

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Human milk-derived extracellular vesicles (HMEVs) are crucial functional components in breast milk, contributing to infant health and development. Maternal conditions could affect HMEV cargos; however, the impact of SARS-CoV-2 infection on HMEVs remains unknown. This study evaluated the influence of SARS-CoV-2 infection during pregnancy on postpartum HMEV molecules. Milk samples (9 prenatal SARS-CoV-2 vs. 9 controls) were retrieved from the IMPRINT birth cohort. After defatting and casein micelle disaggregation, 1 mL milk was subjected to a sequential process of centrifugation, ultrafiltration, and qEV-size exclusion chromatography. Particle and protein characterizations were performed following the MISEV2018 guidelines. EV lysates were analyzed through proteomics and miRNA sequencing, while the intact EVs were biotinylated for surfaceomic analysis. Multi-Omics was employed to predict HMEV functions associated with prenatal SARS-CoV-2 infection. Demographic data between the prenatal SARS-CoV-2 and control groups were similar. The median duration from maternal SARS-CoV-2 test positivity to milk collection was 3 months (range: 1-6 months). Transmission electron microscopy showed the cup-shaped nanoparticles. Nanoparticle tracking analysis demonstrated particle diameters of <200 nm and yields of >1e11 particles from 1 mL milk. Western immunoblots detected ALIX, CD9 and HSP70, supporting the presence of HMEVs in the isolates. Thousands of HMEV cargos and hundreds of surface proteins were identified and compared. Multi-Omics predicted that mothers with prenatal SARS-CoV-2 infection produced HMEVs with enhanced functionalities involving metabolic reprogramming and mucosal tissue development, while mitigating inflammation and lower EV transmigration potential. Our findings suggest that SARS-CoV-2 infection during pregnancy boosts mucosal site-specific functions of HMEVs, potentially protecting infants against viral infections. Further prospective studies should be pursued to reevaluate the short- and long-term benefits of breastfeeding in the post-COVID era.

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Dental-derived stem cells in tissue engineering: the role of biomaterials and host response

Yuan,

Ferreira,

et al. 2023

Regenerative Biomaterials

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Dental-derived stem cells (DSCs) are attractive cell sources due to their easy access, superior growth capacity, and low immunogenicity. They can respond to multiple extracellular matrix (ECM) signals, which provide biophysical and biochemical cues to regulate the fate of residing cells. However, the direct transplantation of DSCs suffers from poor proliferation and differentiation towards functional cells and low survival rates due to local inflammation. Recently, elegant advances in the design of novel biomaterials have been made to give promise to the use of biomimetic biomaterials to regulate various cell behaviors, including proliferation, differentiation, and migration. Biomaterials could be tailored with multiple functionalities, e.g., stimuli-responsiveness. There is an emerging need to summarize recent advances in engineered biomaterials-mediated delivery and therapy of DSCs and their potential applications. Herein, we outlined the design of biomaterials for supporting DSCs and the host response to the transplantation.

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The impact on colostrum oxidative stress, cytokines, and immune cells composition after SARS-CoV-2 infection during pregnancy

Cited by 3 publications

References 81 publications

The effect of Sauropus androgynus (L) Merr leaves decoction on primiparous colostrum immunomodulatory profile: study of Baliness traditional recepies for lactating mother

The effect of Sauropus androgynus (L) Merr leaves decoction on primiparous colostrum immunomodulatory profile: study of Baliness traditional recepies for lactating mother

Prenatal SARS-CoV-2 infection alters postpartum human milk-derived extracellular vesicles

Dental-derived stem cells in tissue engineering: the role of biomaterials and host response

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