The impact of vaccination to control COVID-19 burden in the United States: A simulation modeling approach

Alagöz, Oğuzhan; Sethi, Ajay K.; Patterson, Brian W.; Churpek, Matthew M; Alhanaee, Ghalib; Scaria, Elizabeth; Safdar, Nasia

doi:10.1371/journal.pone.0254456

Cited by 72 publications

(57 citation statements)

References 20 publications

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“…By taking into account vaccination rates from December, 2020 to July, 2021 in Costa Rica, as well as levels of vaccine acceptance, our results suggest that reducing the daily application of first doses by an average of during a 5 month time-frame, Covid-19 related hospitalizations would experience an increase of and , in the scenarios of pre-Delta and Delta circulation, which translates in a and increase in mortality by the end of the study period. These results go in hand with previous studies that evidence the reduction in hospitalization and mortality with high efficacy mass vaccination campaigns 28 , 45 – 47 .…”

Section: Discussionsupporting

confidence: 64%

Projecting the impact of Covid-19 variants and vaccination strategies in disease transmission using a multilayer network model in Costa Rica

García

Mery²,

Vásquez

et al. 2022

Sci Rep

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For countries starting to receive steady supplies of vaccines against SARS-CoV-2, the course of Covid-19 for the following months will be determined by the emergence of new variants and successful roll-out of vaccination campaigns. To anticipate this scenario, we used a multilayer network model developed to forecast the transmission dynamics of Covid-19 in Costa Rica, and to estimate the impact of the introduction of the Delta variant in the country, under two plausible vaccination scenarios, one sustaining Costa Rica’s July 2021 vaccination pace of 30,000 doses per day and with high acceptance from the population and another with declining vaccination pace to 13,000 doses per day and with lower acceptance. Results suggest that the introduction and gradual dominance of the Delta variant would increase Covid-19 hospitalizations and ICU admissions by $$35\%$$ 35 % and $$33.25\%$$ 33.25 % , respectively, from August 2021 to December 2021, depending on vaccine administration and acceptance. In the presence of the Delta variant, new Covid-19 hospitalizations and ICU admissions are estimated to increase around $$24.26\%$$ 24.26 % and $$27.19\%$$ 27.19 % , respectively, in the same period if the vaccination pace drops. Our results can help decision-makers better prepare for the Covid-19 pandemic in the months to come.

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Section: Discussionsupporting

confidence: 64%

Projecting the impact of Covid-19 variants and vaccination strategies in disease transmission using a multilayer network model in Costa Rica

García

Mery²,

Vásquez

et al. 2022

Sci Rep

View full text Add to dashboard Cite

show abstract

“…The government also imposed mandatory use of various preventive non-pharmaceutical interventions in public (including face masks and physical distancing) as well as containment measures (such as case identification, isolation, contact tracing, and quarantine) that have played an important role in decreasing transmission [ 4 , 5 ]. The hope for the return to normalcy has been renewed with the development and approval for emergency use of several vaccine candidates against SARS-CoV-2 to complement the non-pharmaceutical interventions [ 6 , 7 ]. Current evidence suggests that vaccines are among the most effective prevention tools available to address the unprecedented global health crisis as they prevent infection transmission and reduce hospitalization and death [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Predictors of COVID-19 Vaccine Hesitancy in South African Local Communities: The VaxScenes Study

et al. 2022

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South Africa launched a mass COVID-19 vaccination campaign in May 2021, targeting 40 million adults. Understanding predictors of COVID-19 vaccine intentions was required to achieve this goal. We conducted a population-based survey in June–July 2021 using the WHO Behavioral and Social Drivers (BeSD) of COVID-19 Vaccination tool to determine predictors of vaccine hesitancy, defined as intention to refuse or uncertainty whether to accept COVID-19 vaccination. There were 1193 participants, mean age 39 (standard deviation 15) years, and 53% women, of whom 58% trusted information provided by healthcare workers and 32% were vaccine hesitant. Independent predictors of vaccine hesitancy included concerns about side effects (odds ratio (OR) 11.41; 95% confidence interval (CI) 3.5–50.80), lack of access to the online vaccine registration platform (OR 4.75; CI 2.15–10.37), distrust of government (OR 3.0; CI 1.33–6.77), belief in conspiracy theories (OR 3.01; CI 1.32–6.77), having no monthly income (OR 1.84; CI 1.12–3.07), and depending on someone else to make vaccination decision (OR 2.47; CI 1.06–5.77). We identified modifiable predictors of vaccine hesitancy at the start of South Africa’s COVID-19 vaccination rollout. These factors should be addressed by different stakeholders involved in the national immunization program through tailored communication and other effective strategies that increase vaccine literacy, reach low-income households, and engender confidence in government.

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“…For instance, in the economic sector, people have started to use cashless applications for transactions; in the social and education sectors, online platforms have been heavily and forcefully promoted to maintain face-to-face discussion, teaching and learning. In the health sector, the online platforms also have been widely used for webinar, virtual conference, and telemedicine, meanwhile people have adopted healthy lifestyle behaviors, such as wearing masks at all times, physical distancing, supplement consumption, and, ultimately, vaccination to create herd immunity (16,17).…”

Section: Discussionmentioning

confidence: 99%

COVID-19 Vaccines in Indonesia: Knowledge, Attitudes, and Acceptance Among Dental Professionals

et al. 2021

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Background: At the time of writing, the number of Coronavirus Disease 2019 (COVID-19) cases in Indonesia has exceeded 2 million. The COVID-19 pandemic has caused severe disruptions in and unprecedented challenges to healthcare systems, including the one in Indonesia. Healthcare professionals, especially dentists, have an increased risk of contracting the virus. Many dental professionals in Indonesia have been exposed to the virus through close contact with aerosols and droplets from the oral cavities of their patients and have subsequently become infected. The Indonesian government commenced its COVID-19 vaccination program in January 2021. It is necessary to achieve high COVID-19 vaccination coverage rates among health workers. However, immunizations are voluntary, and some healthcare workers may be reluctant to receive them. The aim of this study was to evaluate the knowledge, attitudes, and acceptance of dental professionals of COVID-19 vaccines.Materials and Methods: A cross-sectional study was conducted among dentists taking part in the Indonesia Dental Association webinar in June 2021. Google Docs was used to create an online questionnaire, which was disseminated to the participants at the end of the webinar. The questionnaire consisted of 15 questions developed after being reviewed by experts. The questionnaire collected demographic data (age, gender, location, and affiliation/institution) and data on the dental professionals' knowledge and acceptance of COVID-19 vaccines in Indonesia as well as their attitudes toward COVID-19 vaccines. The respondents selected one option (agree/neutral/disagree) in response to each statement in the questionnaire. For data analysis, the respondents were divided into three groups according to their professional activity/employment category: national hospital (GOV), private hospital (PRIVATE), or academic faculty in a dental school (ACADEMIC). The data were analyzed using descriptive statistics and expressed as frequencies and percentages. A chi-square test was used to investigate the association between professional activity and acceptance of COVID-19 vaccines.Results: In total, 779 dentists from 34 provinces in Indonesia completed the questionnaire. There were 646 (83%) females and 133 (17%) males, with an age range of 24–73 years. In terms of the distribution of professional affiliations, the respondents included 23 (3%) academics, 285 (36.5%) private hospital/private practice practitioners, and 471 (60.5%) national hospital practitioners. In the statistical analysis, unadjusted odds ratios (ORs) were calculated with their 95% confidence intervals (CIs).Conclusions: Acceptance of COVID-19 vaccines is an essential determinant of vaccine uptake and the likelihood of controlling the COVID-19 pandemic. There is agreement between dental professionals in private hospitals and academic faculties (dental school) regarding the need for COVID-19 vaccination. Developing strategies to reduce public hesitation and increase trust is vital for implementing vaccination programs, and dentists can play a role in increasing the uptake of COVID-19 vaccines.

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The impact of vaccination to control COVID-19 burden in the United States: A simulation modeling approach

Cited by 72 publications

References 20 publications

Projecting the impact of Covid-19 variants and vaccination strategies in disease transmission using a multilayer network model in Costa Rica

Projecting the impact of Covid-19 variants and vaccination strategies in disease transmission using a multilayer network model in Costa Rica

Predictors of COVID-19 Vaccine Hesitancy in South African Local Communities: The VaxScenes Study

COVID-19 Vaccines in Indonesia: Knowledge, Attitudes, and Acceptance Among Dental Professionals

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