The impact of urban particulate pollution on skin barrier function and the subsequent drug absorption

Pan, Tai‐Long; Wang, Pei‐Wen; Aljuffali, Ibrahim A.; Huang, Chia‐Wei; Lee, Chiang‐Wen; Fang, Jia‐You

doi:10.1016/j.jdermsci.2015.01.011

Cited by 128 publications

(92 citation statements)

References 44 publications

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“…The targeting of the cerebellum by tretinoin is particularly relevant given that cerebellar abnormalities are a consistent feature of autism [268][269][270]. The transfer of retinoic acid across pig skin is increased by exposure to particulate matter containing polycyclic aromatic hydrocarbons [271].…”

Section: Cosmetic Ingredients Targeting Autism Genesmentioning

confidence: 99%

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Autism genes are selectively targeted by environmental pollutants including pesticides, heavy metals, bisphenol A, phthalates and many others in food, cosmetics or household products

Carter

Blizard

2016

Neurochemistry International

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Section: Cosmetic Ingredients Targeting Autism Genesmentioning

confidence: 99%

“…[227]. The transfer of retinoic acid across pig skin is increased by exposure to particulate matter containing polycyclic aromatic hydrocarbons [271].…”

Section: Cosmetic Ingredients Targeting Autism Genesmentioning

confidence: 99%

Autism genes are selectively targeted by environmental pollutants including pesticides, heavy metals, bisphenol A, phthalates and many others in food, cosmetics or household products

Carter

Blizard

2016

Neurochemistry International

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“…From 2015 to the present (2017) the number of published reports on air pollution and skin increased substantially and covered topics such as: (a) indoor air pollution from cooking accelerated skin aging in Chinese women, and atopic dermatitis increased from other indoor pollutants, such as polyvinyl chloride (PVCs) from wallpaper [51,52]; (b) decreased skin barrier function and increased facial hyperpigmentation (lentigines) from ambient PMs that are known to increase inflammatory skin diseases, ROS and matrix metalloproteinases (MMPs) that degrade collagen [53][54][55][56][57]; and (c) fine airborne PM activated the aryl hydrocarbon receptor (AHR) that resulted in detrimental effects on human keratinocytes [58,59]. Finally, in brief, two recent reviews have summarized the recognized negative impact of ambient air pollution on skin health, which suggested four general mechanisms by which this occurs: (1) generation of ROS; (2) induction of the inflammatory cascade and subsequent impairment of the skin barrier; (3) activation of the AHR which stimulates the expression skin aging genes such as MMPs that degrade collagen; and (4) alterations to the skin microflora [60,61].…”

Section: Air and Water Pollution And The Generation Of Rosmentioning

confidence: 99%

Equol’s Anti-Aging Effects Protect against Environmental Assaults by Increasing Skin Antioxidant Defense and ECM Proteins While Decreasing Oxidative Stress and Inflammation

Lephart

2018

Cosmetics

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Environmental pollutants represent a major problem worldwide that cannot be passively avoided. It is known that skin sensitivities can result from environmental assaults, such as toxins and pollutants in air and water. Additionally, dermal assaults from wind and exposure to seasonal cold temperatures are known. All of these environmental assaults are associated with oxidative stress and the intracellular generation of reactive oxygen species (ROS), which damage DNA, lipids, proteins and mitochondrial function. Additionally, the influence of diet on dermal health and, especially, antioxidant defense in skin function are well established. In this regard, environmental pollution worldwide has generated a high demand for anti-pollution personal care products to protect the skin against the daily exposure of airborne toxins and various other assaults. Major cosmetic companies have anti-pollution personal care products but, in general, the products are formulated with commonly used active ingredients that have been retooled with market strategies to address current environmental pollution treatments. Equol is a new botanical active ingredient compound for skin applications. It has a polyphenolic chemical structure found in plant and food products, and is also classified as an isoflavonoid. Moreover, equol appears to address the need for an active ingredient in personal care products to protect against pollution assaults by increasing antioxidant defense, while inhibiting oxidative stress and inflammation. Separate sections covering equol's enhanced (a) delivery mechanism into human skin; (b) antioxidant effects via Nrf2 activation; (c) effects on extracellular matrix proteins like collagen and elastin and; (d) protection against oxidative stress and inflammation are presented.

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“…The long-term exposure to air pollution can lead to extrinsic skin aging through oxidative stress generated by the particles themselves and/or by associated PAHs. Moreover, PMs have been found to disrupt stratum corneum integrity by 2-fold and mildly damaging tight junctions [20]. Additionally, an increase in soot (per 0.5 × 10 −5 /m) and particles from traffic (per 475 kg/year/km 2 ) has been associated with 20% more pigment spots on the forehead and cheeks [21].…”

Section: Pollution and Its Effect On The Skinmentioning

confidence: 99%

Potential Use of Spin Traps to Control ROS in Antipollution Cosmetics—A Review

Sawant¹

2018

Cosmetics

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Abstract:Pollution from air and sunlight has adverse effects on human health, particularly skin health. It creates oxidative stress, which results in skin diseases, including skin cancer and aging. Different types of antioxidants are used as preventative actives in skin-care products. However, they have some limitations as they also scavenge oxygen. Recently, spin traps are being explored to trap free radicals before these radicals generating more free radicals (cascading effect) and not the oxygen molecules. However, not all spin traps can be used in the topical cosmetic skin-care products due to their toxicity and regulatory issues. The present review focuses on the different pathways of reactive oxygen species (ROS) generation due to pollution and the potential use of spin traps in anti-pollution cosmetics to control ROS.

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The impact of urban particulate pollution on skin barrier function and the subsequent drug absorption

Cited by 128 publications

References 44 publications

Autism genes are selectively targeted by environmental pollutants including pesticides, heavy metals, bisphenol A, phthalates and many others in food, cosmetics or household products

Autism genes are selectively targeted by environmental pollutants including pesticides, heavy metals, bisphenol A, phthalates and many others in food, cosmetics or household products

Equol’s Anti-Aging Effects Protect against Environmental Assaults by Increasing Skin Antioxidant Defense and ECM Proteins While Decreasing Oxidative Stress and Inflammation

Potential Use of Spin Traps to Control ROS in Antipollution Cosmetics—A Review

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