Autism genes are selectively targeted by environmental pollutants including pesticides, heavy metals, bisphenol A, phthalates and many others in food, cosmetics or household products

Carter, C.J.; Blizard, Robert

doi:10.1016/j.neuint.2016.10.011

Cited by 83 publications

(45 citation statements)

References 305 publications

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“…In addition to infection, environmental factors may trigger immune activation. Pollutants, food additives, and cosmetic ingredients have been proposed to interact with genetic predispositions to increase the incidence of ASD partly through inflammatory pathways (Carter and Blizard, 2016). Respiratory irritants in environmental pollution can induce an infection-free MIA response that may contribute to ASD-like behavioral dysfunction and other neurodevelopmental defects (Bilbo et al, 2018).…”

Section: Evidence Of a Role For The Immune System In Neurodevelopmentmentioning

confidence: 99%

Maternal immune activation in neurodevelopmental disorders

Solek

Farooqi

Verly

et al. 2017

Developmental Dynamics

116

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Converging lines of evidence from basic science and clinical studies suggest a relationship between maternal immune activation (MIA) and neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia. The mechanisms through which MIA increases the risk of neurodevelopmental disorders have become a subject of intensive research. This review aims to describe how dysregulation of microglial function and immune mechanisms may link MIA and neurodevelopmental pathologies. We also summarize the current evidence in animal models of MIA. Developmental Dynamics 247:588-619, 2018. © 2017 Wiley Periodicals, Inc.

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Section: Evidence Of a Role For The Immune System In Neurodevelopmentmentioning

confidence: 99%

Maternal immune activation in neurodevelopmental disorders

Solek

Farooqi

Verly

et al. 2017

Developmental Dynamics

116

View full text Add to dashboard Cite

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“…Atrazine (ATZ) and prometryn (PRM) herbicides are the widely used pesticides of the family of triazine, which acts not only as a photosynthesis inhibitor, but also producing strong effects on the human health as mutagenic clastogen agent, endocrine disruptor, and even an effect on the autism incidence . ATZ is by far the most employed triazine pesticide because of its high flexibility in combined treatments .…”

Section: Introductionmentioning

confidence: 99%

Abiotic degradation of s‐triazine pesticides analyzed by surface‐enhanced Raman scattering

Rubira

Constantino

Otero

et al. 2019

J Raman Spectroscopy

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In this work, we explore the use of surface‐enhanced Raman scattering (SERS) on silver (Ag) nanoparticles for the detection of triazine pesticide atrazine and prometryn as well as their degradation products. This tecnique was used to monitor the pesticide degradation both in the commercial samples as well as by the effects of heat and humidity. We have studied the adsorption affinity of these pesticides as well as their degradation products on the employed SERS substrates in order to check the optimal conditions in the detection of both the original pesticide and their degradation products. The presence of these products in triazine pesticides with high solubility in water is of great interest for the human health, but what's even more important is the fact that the pesticide degradation can be favored by very mild conditions of humidity, temperature, and pH, thus leading to high levels of structural modifications, which produce other final compounds with an even higher impact on both human health and environment.

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“…For example, if the curated literature indicates that an exposure influences the expression of a gene and, in separate publications, that gene is associated with a disease, then CTD provides an inference (via the shared gene) that the exposure is linked to the disease; this provides a new testable hypothesis that can be pursued further in laboratory or clinical settings. CTD has been employed in the analysis of a range of brain disorders [215][216][217][218] and can be helpful for guiding future hypotheses about relationships among exposures, genes and psychiatric disorders.…”

Section: Addressing Key Challengesmentioning

confidence: 99%

Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease

Hollander

Cory‐Slechta

Jacka

et al. 2020

Neuropsychopharmacol.

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The etiologic pathways leading to neuropsychiatric diseases remain poorly defined. As genomic technologies have advanced over the past several decades, considerable progress has been made linking neuropsychiatric disorders to genetic underpinnings. Interest and consideration of nongenetic risk factors (e.g., lead exposure and schizophrenia) have, in contrast, lagged behind heritable frameworks of explanation. Thus, the association of neuropsychiatric illness to environmental chemical exposure, and their potential interactions with genetic susceptibility, are largely unexplored. In this review, we describe emerging approaches for considering the impact of chemical risk factors acting alone and in concert with genetic risk, and point to the potential role of epigenetics in mediating exposure effects on transcription of genes implicated in mental disorders. We highlight recent examples of research in nongenetic risk factors in psychiatric disorders that point to potential shared biological mechanisms-synaptic dysfunction, immune alterations, and gut-brain interactions. We outline new tools and resources that can be harnessed for the study of environmental factors in psychiatric disorders. These tools, combined with emerging experimental evidence, suggest that there is a need to broadly incorporate environmental exposures in psychiatric research, with the ultimate goal of identifying modifiable risk factors and informing new treatment strategies for neuropsychiatric disease.

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Autism genes are selectively targeted by environmental pollutants including pesticides, heavy metals, bisphenol A, phthalates and many others in food, cosmetics or household products

Cited by 83 publications

References 305 publications

Maternal immune activation in neurodevelopmental disorders

Maternal immune activation in neurodevelopmental disorders

Abiotic degradation of s‐triazine pesticides analyzed by surface‐enhanced Raman scattering

Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease

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