The impact of treatment for iron deficiency and iron deficiency anemia on nutritional status, physical performance, and cognitive function in geriatric patients

Öztorun, Hande Selvi; Çınar, Esat; Turgut, Tuğba; Sürmeli, Deniz Mut; Bahşi, Remzi; Atmış, Volkan; Aras, Sevgi

doi:10.1007/s41999-018-0065-z

Cited by 8 publications

(12 citation statements)

References 39 publications

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“…In respect of physical function, iron de ciency has also been linked to muscle strength and function declines in hospitalized older patients 38 . When providing older adults with iron supplementation for six months, their grip strength and walking speed were largely improved 39 . Additionally, iron status can also connect with frailty via its association with in ammatory markers (e.g., CRP 40 and IL-6 41 ).…”

Section: Discussionmentioning

confidence: 99%

Frailty detection with routine blood tests: based on the English longitudinal study of ageing (ELSA)

He,

Yang,

Lin

et al. 2024

Preprint

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Purpose Frailty is a rising global health issue in ageing society. Easily accessible and sensitive tools are needed for frailty monitoring while routine blood factors can be potential candidates. Methods Data of 1907 participants (aged 60 years or above) were collected from the 4th to 9th wave of the English longitudinal study of ageing. 14 blood factors obtained from blood tests were included in the analysis. A 52-item frailty index (FI) was calculated for frailty evaluation. Logistic regression and Cox proportional hazards analysis were used to explore the relationships between baseline blood factors and the occurrence of frailty over time respectively. All analyses were controlled for age and sex. Results Our study identified that 8 blood factors (mean corpuscular haemoglobin, HDL, triglyceride, ferritin, hsCRP, dehydroepiandrosterone, haemoglobin, and WBC) involved in inflammatory, nutritional and metabolic processes were associated with frailty. The combined model with these 8 blood factors had an AUC of 0.758 at cross-sectional level. In the Cox proportional hazards analysis, higher triglyceride (HR: 1.30, 95%CI: 1.07 ~ 1.59), WBC (HR: 1.16, 95%CI: 1.05 ~ 1.28), and lower HDL (HR: 0.58, 95%CI: 0.38 ~ 0.90) at baseline were linked to greater risk of developing frailty within 10 years. Compared to adults without abnormal blood factors at baseline, the hazard ratios of participants with two or more abnormal blood factors were almost 2-fold higher in developing frailty over time. Conclusions Routine blood factors, particularly triglyceride, HDL and WBC, could be used for frailty screening in clinical practice and estimate the development of frailty over time.

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Section: Discussionmentioning

confidence: 99%

Frailty detection with routine blood tests: based on the English longitudinal study of ageing (ELSA)

He,

Yang,

Lin

et al. 2024

Preprint

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“…Although the MNA test was designed to detect protein-energy malnutrition and not micronutrient deficiency [ 67 ], some authors [ 38 , 68 ] found significantly lower intakes of iron in individuals with low MNA scores. In addition, iron replacement treatment was shown to have a positive impact on nutritional status of older patients with ID and ID anemia [ 69 ]. Even though in theory, MNA scores can be associated with iron status, to our knowledge, no studies had directly investigated this relationship.…”

Section: Discussionmentioning

confidence: 99%

Iron Status is Associated with Mood, Cognition, and Functional Ability in Older Adults: A Cross-Sectional Study

et al. 2020

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Several conditions are risk factors for iron deficiency (ID), some of which are highly prevalent in older individuals. Despite the amount of evidence pointing for a role of ID in cognition, mood and physical functional ability, the research addressing these associations in older individuals is still scarce. In the present study, 162 older community-dwelling individuals (29.53% classified as ID) were enrolled in a cross-sectional analysis and characterized regarding cognition, mood, functional ability, general nutritional intake and iron status. Assessment of iron status was performed using several blood biomarkers. Storage and erythropoiesis dimensions were positively associated with memory, along with an interaction (moderator effect) between iron storage and nutritional status. A more depressed mood was negatively associated with (iron) transport, transport saturation and erythropoiesis dimensions, and functional tiredness was positively associated with the erythropoiesis dimension. These observations indicate that lower iron status is associated with depressive mood, functional tiredness and poorer memory ability, with the latter moderated by nutritional status. These findings suggest that using iron as a continuous variable may be useful in finding associations with iron homeostasis, eventually missed when iron levels are considered within the usual classification groups.

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“…For example, Hirani et al 1 revealed that every 1 g/dL increase in hemoglobin significantly decreased the risk of HGS, and HGS had a strongly positive association with hemoglobin levels in both cross-sectional and longitudinal analyses. Generally, HGS is influenced by hypertension and diabetes 19 , anthropometry or obesity 9 , aging 3 , 9 , HDL-C 20 , forced expiratory volume 20 , malnutrition 21 , fatigue 4 , 15 , 18 , dyspnea 15 , 18 , muscular exercise 1 , inflammation 4 , 11 , 22 , 23 , and anemia 1 , 3 – 18 , 24 . Anemia affects cognitive performance and physical performance, such as HGS and walking speed 1 , 24 .…”

Section: Introductionmentioning

confidence: 99%

“…Generally, HGS is influenced by hypertension and diabetes 19 , anthropometry or obesity 9 , aging 3 , 9 , HDL-C 20 , forced expiratory volume 20 , malnutrition 21 , fatigue 4 , 15 , 18 , dyspnea 15 , 18 , muscular exercise 1 , inflammation 4 , 11 , 22 , 23 , and anemia 1 , 3 – 18 , 24 . Anemia affects cognitive performance and physical performance, such as HGS and walking speed 1 , 24 . Conversely, anemia treatments may improve HGS, walking speed, and cognitive status 24 .…”

Section: Introductionmentioning

confidence: 99%

“…Anemia affects cognitive performance and physical performance, such as HGS and walking speed 1 , 24 . Conversely, anemia treatments may improve HGS, walking speed, and cognitive status 24 . Although the mechanism linking anemia and low HGS is unclear, however, due to the complexity of associated biological and pathological factors 4 , 15 , subjects with low hemoglobin levels generally have lower muscle and HGS strength than those with normal hemoglobin levels, and anemia is associated with inflammation, which has been identified as a crucial etiology of the disease 1 , 4 , 11 , 22 .…”

Section: Introductionmentioning

confidence: 99%

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Association between anemia and grip strength indices combined with anthropometry in the Korean population

Lee,

Chi

2023

Sci Rep

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Anemia is common in older people and is associated with low hand grip strength (HGS). However, there is no study of the association of anemia with both absolute and various relative HGS indices. Therefore, the objectives of this study are to examine the association of anemia with absolute and relative HGS indices and to evaluate whether the relative HGS indices are useful as risk indices of anemia. In this large-scale cross-sectional study, we analyzed the association of anemia with anthropometric indices, absolute HGS indices, and relative HGS indices using both crude and adjusted binary logistic regression models. A total of 24,022 participants were included in the final analysis. Anemia was defined as a blood hemoglobin concentration of less than 13.0 g/dL for men, less than 11.0 g/dL for pregnant women, and less than 12.0 g/dL for nonpregnant women. We considered covariates such as residential area, marital status, education level, occupation, household income, alcohol consumption, smoking status, muscular exercise, walking exercise, blood pressure, and age for men, while for women, we also included menopause. The mean ages of the subjects in this study were 51.89 ± 0.19 years in the nonanemic group and 66.56 ± 0.61 in the anemic group in men and 52.55 ± 0.19 in the nonanemic group and 51.85 ± 0.44 in the anemic group in women. The number of anemic patients was 570 (5.5%) in men and 1638 (12%) in women. The mean HGS value in the dominant hand was 38.97 ± 0.11 in the nonanemic group and 30.84 ± 0.38 in the anemic group in men and 22.64 ± 0.07 in the nonanemic group and 21.85 ± 0.16 in the anemic group in women. Age was highly associated with anemia in men but not in women. Absolute HGS indices, such as the dominant HGS index and both HGS indices, were negatively associated with anemia in both sexes in all crude and adjusted models. All relative HGS indices were associated with anemia in men, but in women, only dominant HGS divided by height and both HGS divided by height were related to anemia status in all models. The associations between anemia and absolute and relative HGS indices were significantly high in men, while in women, these associations were of moderate strength. Anemia was negatively associated with HGS in the Korean population. The strengths of the associations of anemia with the absolute and relative HGS indices showing the highest association with anemia were similar. Therefore, there is no need to use relative HGS indices as risk factors for anemia, and absolute HGS indices, as easily obtained and cost-effective measurement, are suitable.

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The impact of treatment for iron deficiency and iron deficiency anemia on nutritional status, physical performance, and cognitive function in geriatric patients

Cited by 8 publications

References 39 publications

Frailty detection with routine blood tests: based on the English longitudinal study of ageing (ELSA)

Frailty detection with routine blood tests: based on the English longitudinal study of ageing (ELSA)

Iron Status is Associated with Mood, Cognition, and Functional Ability in Older Adults: A Cross-Sectional Study

Association between anemia and grip strength indices combined with anthropometry in the Korean population

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