The impact of total parenteral nutrition on postoperative recovery in patients treated for advanced stage ovarian cancer

Mendivil, Alberto A.; Rettenmaier, Mark A.; Abaid, Lisa N.; Brown, John V.; Mori, Kristina M.; Goldstein, Bram H.

doi:10.1007/s00404-016-4227-2

Cited by 8 publications

(5 citation statements)

References 22 publications

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“…This could be due to the difference in the analyzed population between the two studies. However, in line with this study [ 34 ], we also found that serum albumin level was significantly lower in the TPN treated patients. Serum albumin often reflects elevation of systemic immune response and metabolism status as a result of traumatic injury and has been shown to be a significant predictor for operative morbidity and surgical outcome [ 35 , 36 ].…”

Section: Discussionsupporting

confidence: 92%

“…On the other hand, another study has demonstrated significantly improved median survival for terminally ill ovarian cancer patients who received TPN [ 22 ]. In the present study, we found that TPN treatment can reduce the time of hospitalization as previously reported [ 3 , 14 , 15 ], but had no impact on time to restoration of bowel function and number of post-operative complications, which was suggested to be otherwise in a previous study [ 34 ]. This could be due to the difference in the analyzed population between the two studies.…”

Section: Discussionsupporting

confidence: 87%

“…In addition, we did not include patients who did not have bowel surgery, which is a potential factor that might affect patients’ nutritional status. Lastly, although our selection criteria for TPN treatment is in line with another previous study [ 34 ], it is slightly different from other reported guidelines [ 37 ]. On the other hand, our study is the first one to investigate the malnutrition status and impact of TPN on the outcome of patients with advanced stage ovarian cancer in a Chinese population.…”

Section: Discussionmentioning

confidence: 75%

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Exploring the malnutrition status and impact of total parenteral nutrition on the outcome of patients with advanced stage ovarian cancer

et al. 2021

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Background Ovarian cancer is a common cancer type in women and is often associated with onset of malnutrition. Total parenteral nutrition (TPN) is a nutritional intervention method that has been reported to have controversial effect on cancer patients. In the present retrospective study, we sought to explore the prevalence of malnutrition assessed by the Nutritional Risk Index (NRI) and its association with survival in advanced stage ovarian cancer patients. We also compared the post-operative outcome of the malnourished patients treated with either TPN or conservative management. Results A total of 415 patients with advanced stage ovarian cancer were separated into 4 nutrition groups based on the NRI scores. We found that a number of factors were significantly different among the 4 nutrition groups, including age, serum albumin level, BMI and NRI; among which serum albumin level and NRI were identified to be independent predictors of progression-free and overall survival. In the moderately and severely malnourished patients, those who were treated with TPN had significantly shorter hospitalization period, lower serum albumin level and lower BMI after surgery. In addition, serum albumin level, use of TPN and number of patients with complications were closely related to the hospital stay duration. Conclusion Malnutrition status is closely associated with survival of advanced stage ovarian cancer patients. These patients may benefit from TPN treatment for reduced hospitalization, especially with the onset of hypoalbuminemia.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 75%

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Exploring the malnutrition status and impact of total parenteral nutrition on the outcome of patients with advanced stage ovarian cancer

et al. 2021

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“…In line with another previous study (31) and our recent findings (32), we found that serum albumin levels both before and after the nutritional intervention were significantly lower in the TPN treated patients. Serum albumin often reflects elevation of systemic immune response and metabolism status as a result of traumatic injury.…”

Section: Discussionsupporting

confidence: 93%

Total Parenteral Nutrition Treatment Improves the Nutrition Status of Gynecological Cancer Patients by Improving Serum Albumin Level

et al. 2022

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BackgroundMalnutrition is often observed in gynecological cancer patients, however its prevalence in these patients remains largely unexplored. Total parenteral nutrition (TPN) is a nutritional intervention method that has controversial treatment outcome on gynecological cancer patients. The present retrospective study is designed to evaluate the nutrition status and TPN treatment outcome on patients diagnosed with endometrial, cervical or ovarian malignant tumors.MethodsMedical records of a total of 263 patients treated at the First Hospital of Shanxi Medical University, China were included. Nutrition status was assessed by patient-generated subjective global assessment (PG-SGA). Patients were grouped based on nutrition status, cancer type or treatment strategy for clinical characteristic comparison. Multivariable logistic regression analysis was used to identify predictors for malnutrition status and hospital stay duration.ResultsPresence of endometrial and cervical cancer, body weight before nutritional intervention and serum albumin level (P < 0.001 for all) were found to be significant predictors for malnutrition status in gynecological cancer patients. In the malnourished patients, those who were treated with TPN had significantly lower serum albumin levels before and after treatment (P < 0.001) and PG-SGA scores after treatment. Also, TPN treatment could significantly increase the serum albumin levels in these patients after 1 week. In addition, shorter hospitalization period was needed for TPN-treated endometrial (P = 0.019) and ovarian (P < 0.001) patients. Moreover, serum albumin levels (P < 0.001), use of TPN treatment (P = 0.025) and nutrition status (P = 0.010) were identified to be independent predictors for hospital stay duration.ConclusionOur results suggest that malnutrition is a significant clinical manifestation in gynecological cancer patients who may benefit from TPN treatment for reduced hospitalization and improved serum albumin levels.

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“…A number of laboratory parameters have been shown to be associated with impaired prognosis in patients with EOC including markers of inflammation, serum tumor markers, thrombocytosis, serum level of angiotensinconverting enzyme and cell-surface markers expressed by the ANTICANCER RESEARCH 38: 5127-5130 (2018) 5128 tumor cells (10)(11)(12)(13)(14). Interestingly, recently published studies investigated whether medical interventions such as antihypertensive medication or parenteral nutrition influence the prognosis of patients with cancer by altering circulating inflammatory markers or serum albumin levels (15,16). Our study is in line with the aforementioned data, as the independent prognostic factor ascertained in our study, namely the serum level of creatinine, can be changed by medical interventions.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Serum Creatinine Levels in Patients with Epithelial Ovarian Cancer

et al. 2018

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The impact of total parenteral nutrition on postoperative recovery in patients treated for advanced stage ovarian cancer

Cited by 8 publications

References 22 publications

Exploring the malnutrition status and impact of total parenteral nutrition on the outcome of patients with advanced stage ovarian cancer

Exploring the malnutrition status and impact of total parenteral nutrition on the outcome of patients with advanced stage ovarian cancer

Total Parenteral Nutrition Treatment Improves the Nutrition Status of Gynecological Cancer Patients by Improving Serum Albumin Level

Prognostic Value of Serum Creatinine Levels in Patients with Epithelial Ovarian Cancer

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