Prognostic Value of Serum Creatinine Levels in Patients with Epithelial Ovarian Cancer

Lafleur, Judith; Hefler-Frischmuth, Katrin; Grimm, Christoph; Schwameis, Richard; Gensthaler, Lisa; Reiser, Elisabeth; Hefler, Lukas

doi:10.21873/anticanres.12834

Cited by 19 publications

(13 citation statements)

References 13 publications

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“…Although biomarkers associated with OS in patients with CRC may be moderately predictive of survival, additional research and evaluation are needed to improve their predictive utility (18)(19)(20)(21). In this study, we evaluated association between Scr levels and OS in patients with CRC because Scr has been reported to be predictive of prognosis in many cancers (8)(9)(10)(11). Our study revealed a correlation between Scr concentrations and OS in patients with CRC, which was consistent with previous studies in other cancers.…”

Section: Discussionsupporting

confidence: 88%

“…Willegger et al studied 132 patients undergoing sarcoma resection and found that Scr could be used as a predictive biomarker for disease-specific outcomes in myofibroblastic and fibroblastic sarcomas (8). In a retrospective cohort study, Scr was an independent predictor of overall survival (OS) in 498 patients with primary epithelial ovarian cancer (9). Z ̇yczkowski et al found that Scr may be useful for estimating the 5-year survival of patients with renal cell carcinoma (10).…”

Section: Introductionmentioning

confidence: 99%

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Association Between Serum Creatinine Concentrations and Overall Survival in Patients With Colorectal Cancer: A Multi-Center Cohort Study

et al. 2021

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BackgroundColorectal cancer (CRC) is one of the most common malignancies throughout the world, with high rates of morbidity and mortality. Previous studies reported that serum creatinine (Scr) concentrations were associated with overall survival (OS) in cancer patients, but little is known about the association between Scr and OS in patients with CRC. This study investigated the relationship between Scr concentrations and OS in patients with CRC and examined possible effect modifiers.MethodsA retrospective cohort, including 1,733 patients with CRC, was established from a multi-center clinical study. Patients were divided into low (<71 μmol/L in men or <59 μmol/L in women), normal (71-104 μmol/L in men or 59-85 μmol/L in women) and high (>104 μmol/L in men or >85 μmol/L in women) Scr groups. Cox regression analysis was used to examine association between Scr concentrations and OS. Stratified (subgroup) analyses were used to examine men and women separately. Interaction tests were used to evaluate associations between each variable and OS, as well as possible interactions of these variables with Scr levels. Cross-classified analyses were used only in men.ResultsPatients with low [hazard ratio (HR) = 1.43, 95% confidence interval (CI) = 1.19-1.72; P < 0.001] or high (HR = 1.89, 95% CI = 1.36-2.63; P < 0.001) Scr level had a significantly lower OS than patients with normal Scr levels. Significant interactions with Scr concentrations were observed for body mass index (P for interaction = 0.019) in men.ConclusionLow or high Scr concentration is associated with significantly lower OS in patients with CRC. Future study is warranted to investigate the underlying mechanism.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Association Between Serum Creatinine Concentrations and Overall Survival in Patients With Colorectal Cancer: A Multi-Center Cohort Study

et al. 2021

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“…KIF20A overexpression predicted unfavorable clinical outcome and had potential to serve as a useful prognostic biomarker for epithelial OC patients [13]. The high preoperative serum level of Creatinine was associated with poor survival, which indicated that it might be an additional independent prognostic parameter in patients with epithelial OC [14]. Nucleus and/or cytoplasm of β-catenin expression might be associated with tumor progression and subsequently represent a predictive factor of poor prognosis in OC patients [15].…”

Section: Discussionmentioning

confidence: 99%

Survival-associated transcriptome analysis in ovarian cancer

Xu¹,

Zhou²,

Wang³

et al. 2020

EJGO

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Purpose of investigation: Ovarian Cancer (OC) is one of the most lethal gynecologic cancers worldwide. Despite the standard treatment, including radical resection, systemic chemotherapy, and targeted drugs for patients, survival rates remain low. This study provides new ideas for the diagnosis and treatment of Ovarian Cancer. Material and Methods: We performed Kaplan-Meier analysis on the transcriptome of Ovarian Cancer based on RNA-Seq data from The Cancer Genome Atlas (TCGA). Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and Gene Ontology (GO) enrichment were used for pathway and functional enrichment. Protein-protein interaction (PPI) network was constructed and visualized by SRING and Cytoscape. Results: A total of 1693 genes associated with survival were identified. The Kyoto Encyclopedia of Genes and Genomes pathway and Gene Ontology enrichment analysis revealed that these selected genes were differently enriched in numerous functional pathways. The top ten hub genes (RIPK4, HSPA8, FOS, STAT1, CD40LG, FGF2, RAC1, CXCR4, PRPF19, and CXCL10) were identified in our PPI network. Three highly connected cluster modules were differently enriched in several functional pathways. Conclusion: These key biomarkers in Ovarian Cancer may have diagnostic and therapeutic value in the future.

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“…Similarly, contrasting changes in serum urea levels, the final metabolite of amino acid degradation, were reported in hepatocellular and renal carcinomas in females, suggesting that this parameter may be used as an early detection alternative for these types of malignancies [ 26 , 27 ]. Creatinine, the final product of arginine and glycine degradation, has also been investigated in different types of cancer, sustaining its prognostic character in several types of epithelial cancers [ 28 , 29 , 30 ]. However, in oral cancer, scientific data regarding the assessment of protein metabolism processes and their specific pathways is scarce, sustaining the need for an in-depth investigation to clarify the complex metabolic events associated with oral cancer pathogenesis.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Serum Urea, Creatinine and Uric Acid in Oral Cancer

Căruntu

Moraru

Ciubotaru³

et al. 2022

JCM

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Background: Oral squamous cell carcinoma (OSCC) is a common malignancy worldwide, leading to significant disease-associated social and financial burdens. The investigation of underlying mechanisms involved in carcinogenesis and tumor progression in OSCC might provide new therapeutic perspectives with an impact on disease control and patient survival. Our study aims to investigate the interrelation between metabolic processes, expressed through final catabolism products and clinicopathological characteristics in OSCC. Materials and methods: This is a single cancer comparative retrospective study investigating metabolic byproducts, namely serum urea, creatinine and uric acid, detected at the moment of diagnosis in patients with OSCC, in comparison to healthy controls. Clinical and paraclinical data regarding exposure to risk factors, disease staging and pathological characteristics were collected for all patients. Subjects with co-existing systemic or metabolic diseases, or with a history of malignancy, were excluded from the study. Subsequently, the metabolic byproducts revealing significant changes in OSCC patients were considered for a correlation analysis with the disease clinico-pathological characteristics. Results: Blood levels for urea, creatinine and uric acid were determined in a total of 225 subjects: 145 patients diagnosed with OSCC and 80 healthy control subjects admitted to our hospital between 2016 and 2021. The comparative analysis between groups revealed that the serum urea level was significantly lower in OSCC patients (p = 0.0344). Serum creatinine and uric acid did not reveal significant differences between groups. Furthermore, in advanced stages of the disease (stages III and IV), the blood level of urea was significantly lower compared to incipient OSCC (stages I and II) (p = 0.003). We found a negative correlation of serum urea levels with smoking (p = 0.0004) and cervical lymph node metastasis (p = 0.0070), and a positive correlation with aging (p = 0.0000). We found no significant correlation of serum urea with primary tumor size (p = 0.5061) and patient survival (p = 0.2932). Conclusions: Decreased serum urea levels are detected in patients with advanced OSCC, in correlation with lymph node metastasis. The invasive features of tumor cells in OSCC might be promoted in association with dysregulation of protein catabolism processes, facilitating aggressive behavior in OSCC.

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Prognostic Value of Serum Creatinine Levels in Patients with Epithelial Ovarian Cancer

Abstract: The preoperative serum level of creatinine may be useful as an additional independent prognostic parameter in patients with EOC.

Cited by 19 publications

References 13 publications

Association Between Serum Creatinine Concentrations and Overall Survival in Patients With Colorectal Cancer: A Multi-Center Cohort Study

Association Between Serum Creatinine Concentrations and Overall Survival in Patients With Colorectal Cancer: A Multi-Center Cohort Study

Survival-associated transcriptome analysis in ovarian cancer

Assessment of Serum Urea, Creatinine and Uric Acid in Oral Cancer

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