The impact of thyroid tumor features on lymph node metastasis in papillary thyroid carcinoma patients in head and neck department at KAMC: A retrospective cross-sectional study

Abstract

Introduction Papillary thyroid carcinoma (PTC) is the most prevalent type of thyroid cancer. It is one of the most common types of malignancy of the thyroid that spreads to cervical lymph nodes. Lymph node metastasis (LNM) is an important factor when determining recurrence risk, and determining the extent of lymph node involvement can guide treatment. Our main objective is to evaluate the association between the size of the tumor and the number of lymph node metastases in patients with PTC. Methods: We conducted an electronic retrospective chart review of 125 patients with PTC followed in the Head and Neck Department at KAMC from 2009 to 2020. Twenty-two patients included in our study were pathologically and clinically diagnosed and confirmed to have LNM of PTC. Results: The study included 22 PTC patients who had undergone lymph node dissections. Patients had a median age of 38.8 years (IQR = 32.2–54.5), and the median tumor size was 20.5 mm. The most commonly affected level of the neck was IV (76.2%). Distant metastasis M1 was seen in only two patients (9.1%). Tumors sizes >30mm (75%) had ≥5 LNM. Most cases were the classic subtype PTC. For the site of the tumor, the site had a significant impact on the number of LNM (p = 0.004). Multifocality had a high impact on LNM (p = 0.019). Conclusions: This study showed no association between the size of PTC and the number of LNMs. The bilaterality of PTC was significantly associated with a high number of LNMs.

Influence of S100A2 in Human Diseases

“…Papillary carcinoma is the most common type of well-differentiated thyroid malignancy, and the representative oncogenic basis of this tumor is radiation exposure in vivo [ 50 ]. Although 89.5% of thyroid papillary carcinomas show positive expression of S100A2 in vivo [ 51 ], the detailed prognostic impact of S100A2 in thyroid papillary carcinoma remains unclear.…”

Low Expression of miR-491-3p Is Correlated with Lymph Node Metastasis in Gastric Cancer

“…Lymph node metastases (LNM), an intermediate metastatic step from the primary site to the lymph nodes, represent an aggressive yet curable state for many solid tumors [ 1 , 2 ]. Although LNM was the direct reason for distant metastases, it reflects the biological selection of more aggressive subpopulations showing close relation with local and/or regional recurrence [ 3 , 4 ]. As demonstrated by many researchers, the presence of LNMs is associated with decreased postoperative survival in gastric cancer [ 5 , 6 ], being the most important prognostic factors [ 7 ].…”

An Unusual Mixed Thyroid Carcinoma: A Surgical and Pathological Rarity

“…Although it has not shown much evidence of improvement in survival [ 12 ], it can be useful in patients with neck node involvement [ 1 ]. According to a study done in Saudi Arabia, the most common neck node involved is level IV followed by level III nodes [ 13 ]. In the above case, level V lymph nodes were enlarged which makes it rare.…”