The impact of the leucine 7 to proline 7 polymorphism of the neuropeptide Y gene on postprandial lipemia and on the response of serum total and lipoprotein lipids to a reduced fat diet

Abstract

Objective: The aim of the study was to examine the impact of the leucine7 to proline7 (Leu7Pro) polymorphism of the NPY gene on postprandial (PP) lipemia, post-heparin plasma lipoprotein lipase (LPL) and hepatic lipase (HL) activities, and the response of serum lipids to a reduced fat diet. Design and subjects: Seven middle-aged obese subjects with Leu7Pro genotype were matched with seven subjects with Leu7Leu genotype for gender, age, apolipoprotein E phenotype and BMI. These 14 subjects participated in the oral 8 h fat tolerance test. Sixty-eight slightly obese middle-aged subjects (10 with the Leu7Pro genotype) had participated in intervention studies and consumed a reduced fat diet for 8 weeks.Results: There were no statistically significant differences in PP areas under the curve of plasma total triglycerides (TG), chylomicron TG, VLDL-TG or insulin between the genotype groups. The TG-to-cholesterol (C) ratio in VLDL was significantly lower in the subjects with Leu7Pro genotype compared to those with the Leu7Leu genotype at time points 30 min and 1 h in the fat tolerance test. Heparin-induced activities of LPL or HL or the response of serum total or LDL-C to the reduced fat diet did not differ between the groups. Conclusions: The NPY genotype neither affects the magnitude of postprandial lipemia induced by a fat tolerance test nor the response of serum total lipids or lipids in different lipoprotein classes to the reduced fat diet. However, this preliminary study suggests that there might be compositional differences in the lipoprotein particles between the genotype groups that affect postprandial lipid metabolism.

Association of Neuropeptide-Y (NPY) and Interleukin-1beta (IL1B), Genotype-Phenotype Correlation and Plasma Lipids with Type-II Diabetes

“…However, Leu7Pro polymorphism was not related to serum LDL-C, HDL-C, and triglyceride concentrations in coronary heart disease sufferers [ 46 ]. Schwab et al [ 47 ] revealed that Leu7Pro genotype does not affect BMI and lipid concentrations. Interestingly, our results are in accordance to these where NPY +1128 T/C SNP is associated with increased LDL.…”

Leucine 7 to Proline 7 Polymorphism in the Preproneuropeptide Y Is Associated With Proteinuria, Coronary Heart Disease, and Glycemic Control in Type 1 Diabetic Patients

“…At this point, how the polymorphism causes a potentially altered NPY effect on serum lipids is not known, although an altered triglyceride metabolism via specific stimulation of lipoprotein lipase has been suggested (21). The Leu7Pro polymorphism has also been suggested to alter the composition of the lipoprotein particles affecting the postprandial lipid metabolism (22).…”

Polymorphisms in LEP and NPY genes modify the response to soluble fibre Plantago ovata husk intake on cardiovascular risk biomarkers

“…In addition, PYY suppresses circulating concentrations of ghrelin (Huda et al 2006), and several studies suggest a role of ghrelin in the regulation of lipid metabolism (Barazzoni et al 2005;Varela et al 2011). Finally, it has been demonstrated that PYY inhibits NPY neuronal activity, and various studies suggest that NPY plays a role in lipid metabolism (Blumenthal et al 2002;Schwab et al 2002). All together, the results of our study suggest that the rs162430 polymorphism in the PYY gene may have a functional effect in altering PYY production and influencing the hypotriglyceridaemic effect of dietary fibre intake.…”