The impact of the frequency of moderate exercise on memory and brain-derived neurotrophic factor signaling in young adult and middle-aged rats

Chronic BDNF deficiency leads to an age-dependent impairment in spatial learning

“…Therefore, we analyzed the expression levels of signaling competent full-length (FL) and the dominant negative truncated (T1) TrkB receptors in the hippocampus of differently aged BDNF +/À and wild type mice and detected a similar decline in the expression of both FL-TrkB and TrkB-T1 receptors for both genotypes (Fig. 4), thus corroborating several previous studies (Costa et al, 2012;Croll et al, 1998;Silhol et al, 2005). Recently, a compensatory up-regulation of TrkB receptors in the hippocampus of 7.5 months old BDNF +/À mice has been reported (Carreton et al, 2012).…”

Exercise-induced improvement in cognitive performance after fimbria-fornix transection depends on the timing of exercise administration

“…Understanding the effects of exercise on functional recovery after brain injury relates to the nature, amount and intensity of the physical activity (Costa et al, 2012;Goekint et al, 2012;Shen et al, 2013;Wogensen et al, 2015). Leasure and Jones (2008) compared neurogenesis after forced and voluntary exercise and reported significant disparities given the inherent differences in the intensity and duration (rapid and short duration vs. slower and more consistent intensities) of these two forms of exercise.…”

Effect of endurance training on seizure susceptibility, behavioral changes and neuronal damage after kainate-induced status epilepticus in spontaneously hypertensive rats

“…Endurance training has a beneficial effect on several factors involved in epileptogenesis and concomitant impairments: it facilitates significantly functional recovery after trauma by reducing apoptosis, increase neurogenesis and expression of neurotrophic factors, reduces oxidative stress, improves brain vascularization and restores cognitive functions (Costa et al, 2012;van Praag, 2009;Cotman and Berchtold, 2002;Laurin et al, 2001).…”