Effect of endurance training on seizure susceptibility, behavioral changes and neuronal damage after kainate-induced status epilepticus in spontaneously hypertensive rats

Tchekalarova, Jana; Shishmanova, M.; Atanasova, Dimitrinka; Stefanova, M.; Alova, L; Lazarov, Nikolai; Georgieva, Katerina

doi:10.1016/j.brainres.2015.08.022

Cited by 13 publications

(10 citation statements)

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“…Ligtenberg et al (1998) demonstrated that aerobic training reduced anxiety measures in patients with type 2 diabetes. This notion has also been supported by various behavioral studies in animals, which reported training protocols that induced an anxiolytic effect in rodents (Ke et al, 2011;Tchekalarova et al, 2015;Ghodrati-Jaldbakhan et al, 2017). On the other hand, some studies failed to demonstrate the anxiolytic effect of exercise training (Chaouloff, 1994;Hoffman et al, 2015;Georgieva et al, 2017), as well as Fuss et al (2010a;2010b), which reported a contrary result suggesting an anxiogenic effect of exercise training.…”

Section: Introductionmentioning

confidence: 75%

“…In the literature, there are contradictory results regarding the effect of exercise. Some authors reported an anxiolytic effect with training (Ke et al, 2011;Tchekalarova et al, 2015;Ghodrati-Jaldbakhan et al, 2017), and some observed no differences (Chaouloff, 1994;Hoffman et al, 2015;Georgieva et al, 2017). Then, others reported an exercise-induced anxiogenic effect (Fuss et al, 2010a;2010b).…”

Section: Discussionmentioning

confidence: 99%

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Aerobic exercise has an anxiolytic effect on streptozotocin-induced diabetic rats

Çalışkan¹,

Akat²,

Ömercioğlu³

et al. 2020

Acta Neurobiologiae Experimentalis

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Diabetes is a metabolic disorder characterized by hyperglycemia and impaired insulin secretion or action. Psychological comorbidities, such as depression and anxiety, are more common in people with diabetes. Exercise results in anxiolytic effects, as demonstrated in numerous studies. This study aims to evaluate potential anxiolytic effects of aerobic exercise in streptozotocin (STZ)-induced diabetes. Male Wistar albino rats (n=40) were randomly divided into four groups of control, exercise, diabetes, and diabetes + exercise. Diabetes was induced with a single i.p. injection of STZ. The incremental load test was applied to exercise groups to determine maximal exercise capacity. Rats exercised on a treadmill at 70% of their maximal capacity for 45 min, five days per week for 12 weeks. On the day after the last exercise session the open field test and elevated plus maze test were carried out. Diabetes caused an increase in anxiety level, reflected in stretch-attend posture, self-grooming behaviors, and freezing time, with no significant changes for other behavioral parameters. Training normalized diabetes-induced deteriorations and also induced a significant anxiolytic effect both on diabetic and non-diabetic rats. This effect was observed for all behavioral parameters. The results of the open field test and elevated plus maze were consistent. The current results demonstrated a slight increase in anxiety with diabetes and a prominent anxiolytic effect of aerobic exercise. Considering the conflicting results in exercise-anxiety studies, this study highlights the importance of individually designed exercise protocols.

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Section: Introductionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Aerobic exercise has an anxiolytic effect on streptozotocin-induced diabetic rats

Çalışkan¹,

Akat²,

Ömercioğlu³

et al. 2020

Acta Neurobiologiae Experimentalis

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“…In this respect, Novaes Gomes et al (63) demonstrated that animals subjected to pilocarpine-induced SE in the postnatal period (at P28) and then submitted to a physical exercise program during their adolescent period (between P31 and P90) presented a reduced seizure frequency and beneficial effects on hippocampal plasticity in later stages of life. In line with Gomes da Silva et al study (28), four weeks of aerobic exercise in hypertensive rats attenuated the development of KA-induced-SE (49). As highlighted by Arida and collaborators (64), suggesting the contribution of physical activity as a potential candidate for stress reduction in epilepsy, one possible mechanism for this effect is that physical stress generated before brain insult induced by SE "can prepare the stress system for new challenges."…”

Section: Effect Of Physical Exercise On Behavioral Manifestations Of Seizuresmentioning

confidence: 59%

The Potential Role of Previous Physical Exercise Program to Reduce Seizure Susceptibility: A Systematic Review and Meta-Analysis of Animal Studies

et al. 2021

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Background: Clinical and pre-clinical studies indicate a reduction in seizure frequency as well as a decrease in susceptibility to subsequently evoked seizures after physical exercise programs. In contrast to the influence of exercise after epilepsy previously established, various studies have been conducted attempting to investigate whether physical activity reduces brain susceptibility to seizures or prevents epilepsy. We report a systematic review and meta-analysis of different animal models that addressed the impact of previous physical exercise programs to reduce seizure susceptibility.Methods: We included animal model (rats and mice) studies before brain insult that reported physical exercise programs compared with other interventions (sham, control, or naïve). We excluded studies that investigated animal models after brain insult, associated with supplement nutrition or drugs, that did not address epilepsy or seizure susceptibility, ex vivo studies, in vitro studies, studies in humans, or in silico studies. Electronic searches were performed in the MEDLINE (PubMed), Web of Science (WOS), Scopus, PsycINFO, Scientific Electronic Library Online (SciELO) databases, and gray literature, without restrictions to the year or language of publication. We used SYRCLE's risk of bias tool and CAMARADES checklist for study quality. We performed a synthesis of results for different types of exercise and susceptibility to seizures by random-effects meta-analysis.Results: Fifteen studies were included in the final analysis (543 animals), 13 of them used male animals, and Wistar rats were the most commonly studied species used in the studies (355 animals). The chemoconvulsants used in the selected studies were pentylenetetrazol, penicillin, kainic acid, pilocarpine, and homocysteine. We assessed the impact of study design characteristics and the reporting of mitigations to reduce the risk of bias. We calculated a standardized mean difference effect size for each comparison and performed a random-effects meta-analysis. The meta-analysis included behavioral analysis (latency to seizure onset, n = 6 and intensity of motor signals, n = 3) and electrophysiological analysis (spikes/min, n = 4, and amplitude, n = 6). The overall effect size observed in physical exercise compared to controls for latency to seizure onset was −130.98 [95% CI: −203.47, −58.49] (seconds) and the intensity of motor signals was −0.40 [95% CI: −1.19, 0.40] (on a scale from 0 to 5). The largest effects were observed in electrophysiological analysis for spikes/min with −26.96 [95% CI: −39.56, −14.36], and for spike amplitude (μV) with −282.64 [95% CI: −466.81, −98.47].Discussion:Limitations of evidence. A higher number of animal models should be employed for analyzing the influence of exerciseon seizure susceptibility. The high heterogeneity in our meta-analysis is attributable to various factors, including the number of animals used in each study and the limited number of similar studies. Interpretation. Studies selected in this systematic review and meta-analysis suggest that previous physical exercise programs can reduce some of the main features related to seizure susceptibility [latency seizure onset, spikes/min, and spike amplitude (μV)] induced by the administration of different chemoconvulsants.Systematic Review Registration: PROSPERO, identifier CRD42021251949; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=251949.

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“…Epilepsy is a socially important disease characterized by a persistent predisposition to generate epileptic seizures with neurobiological, cognitive, psychological, and social consequences. Systematic physical exercise, on one hand, reduces the severity and frequency of seizures, and on the other hand, raises the seizure threshold in both animal models with epilepsy [47,48] and in clinical trials with epileptic patients [49]. Although the mechanisms are not fully explained, it is believed that due to its neuroprotective effect, physical exercise successfully counteracts harmful factors, such as distress, intoxication, degenerative changes, and circulatory disturbance, Outdoor Recreation: Physiological Effects and Prevention of Socially Important Diseases DOI: http://dx.doi.org /10.5772/intechopen.93331 which can lead to seizures and impairment of cognitive functions in these patients [50].…”

Section: Mental Healthmentioning

confidence: 99%

Outdoor Recreation: Physiological Effects and Prevention of Socially Important Diseases

Boyadjiev¹,

Georgieva²,

Hristova³

2021

Outdoor Recreation - Physiological and Psychological Effects on Health

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Physical activity improves the condition of the cardiovascular system, respiration, muscles, and metabolism and increases physical working capacity. This review of physiological effects and adaptation mechanisms of the outdoor recreation and its health benefits provides accessible information from a scientific point of view and research practice. Increased frequency of many socially important diseases such as diabetes mellitus type 2, metabolic syndrome and obesity, cardiovascular diseases, and others is associated with dramatically decreased physical activity in the last decades. Outdoor recreation for children, adolescents, adults, and older population is important for the prevention of these conditions. In this chapter, the authors describe in detail the physiological effects of different kinds of outdoor recreation physical activity with different intensities (such as walking, cycling, skiing, rowing, climbing, practicing some outdoor sports, etc.) and assess their benefits in the prevention of socially important diseases.

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Effect of endurance training on seizure susceptibility, behavioral changes and neuronal damage after kainate-induced status epilepticus in spontaneously hypertensive rats

Cited by 13 publications

References 77 publications

Aerobic exercise has an anxiolytic effect on streptozotocin-induced diabetic rats

Aerobic exercise has an anxiolytic effect on streptozotocin-induced diabetic rats

The Potential Role of Previous Physical Exercise Program to Reduce Seizure Susceptibility: A Systematic Review and Meta-Analysis of Animal Studies

Outdoor Recreation: Physiological Effects and Prevention of Socially Important Diseases

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