The Impact of the Discovery of IgE on the Practice of Allergy

Yunginger, John W.; Gleich, Gerald J.

doi:10.1016/s0031-3955(16)33097-8

Cited by 12 publications

(1 citation statement)

References 40 publications

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“…The RAST test has been widely used as an in vitro test of ragweed sensitivity; corre lation have been made with skin reactivity, leukocyte histamine release, clinical history and results of provocative nasal challenges [12,13,21]. The RAST test has proven less sensitive than skin test procedures but has correlated well with provocative nasal chal lenge and with maximal tolerated dose of ragweed allergen administered during a course of 'rush' immunotherapy in some al lergic patients [13].…”

Section: Discussionmentioning

confidence: 99%

Studies of the Radioallergosorbent Test and the Lymphocyte Stimulation Index in Symptomatic Ragweed Pollenosis

Yoo¹,

Kuo²,

Rajtora³

et al. 1978

Int Arch Allergy Immunol

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We followed 47 ragweed hay fever patients (not on immunotherapy) through a ragweed season by means of clinical evaluation and symptom scores. The radioallergosorbent test (RAST) and lymphocyte stimulation index (LSI) were done to determine their reliability as predictors of clinical symptomatology. Symptom scores of 10 or above, denoting at least moderate daily symptoms, occurred in 36 patients (80%). Preseasonally, RAST class 2 or above was found in 34 patients (75%), of whom 29 patients (64%) had symptom scores of 10 or above. At that time, LSI was elevated in about 50% of the patients. Patients in RAST class 3 had the highest LSI as a group. Seasonal exposure boosted the LSI in 50% of the patients, whereas 25% were unchanged and 25% showed a decrease. The results suggest that neither RAST nor LSI are reliable predictors of clinical severity in ragweed pollenosis.

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Section: Discussionmentioning

confidence: 99%

Studies of the Radioallergosorbent Test and the Lymphocyte Stimulation Index in Symptomatic Ragweed Pollenosis

Yoo¹,

Kuo²,

Rajtora³

et al. 1978

Int Arch Allergy Immunol

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Recent Advances in Bronchial Asthma

Flod¹,

Franz²,

Galant³

1976

Arch Pediatr Adolesc Med

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\s=b\Bronchial asthma in childhood is a major pediatric problem for the physician, both as an acute emergency and as a chronic disease. To adequately manage asthma, one must have a firm understanding of its pathogenesis, and the clinical aspects of diagnosis and therapy. We review important developments in the area of the basic mechanisms causing bronchial obstruction, and methods of measuring the abnormalities present. This presentation includes the fields of neuropharmacology, biochemistry, immunology, and pulmonary physiology. With this background, the clinical aspects of diagnosis and therapy are explored. The role of the allergy history, skin testing, measurement of serum IgE antibodies, and target organ provocation testing are placed in perspective. Therapy involving avoidance measures, use of pharmacologic agents and injection therapy with inhalant allergens are discussed in detail.(Am J Dis Child 130: [890][891][892][893][894][895][896][897][898][899] 1976) Many new and exciting advances in the understanding of bron¬ chial asthma have been made in the last decade. These developments have resulted in a more rational approach to the asthmatic child. The review presented here summarizes this new information by considering the basic scientific aspects of the pathogenesis of asthma, followed by discussion of the recent developments in diagnosis and therapy. PATHOGENESIS OF BRONCHIAL ASTHMA NeuropharmacologyBronchial asthma can no longer be viewed solely as an immunologie disease. The clinical observation that several stimuli, including chemical mediators, irritants, certain respira¬ tory infections, emotional and physi¬ cal factors, as well as allergen chal¬ lenge, can result in bronchospasm, created the need for a broader concept in underlying abnormality.In the early 1960s, Szentivanyi1 advanced the theory of /3-adrenergic blockade as a possible unifying path¬ ogenic mechanism in asthma. This theory proposes that many of the stimuli that result in the clinical syndrome of asthma do so by causing release of potent chemical mediators of inflammation such as the kinins, slow-reacting substance of anaphy¬ laxis (SRS-A), histamine, serotonin, and acetylcholine. The mediators, in turn, cause both bronchoconstriction and secretion of epinephrine as a homeostatic response. If /5-adrenergic receptors are normally responsive, activation by epinephrine will balance concurrent a-adrenergic and cholinergic receptor stimulation, and airway patency will be maintained. However, if /3-receptors are defective, bronchoconstriction will result.Evidence for generalized /^-blockade in asthma includes metabolic, pulmo¬ nary, and hématologie changes. There is less elevation of serum glucose, lactate, and pyruvate levels following administration of the ß-adrenergic stimulants, isoproterenol hydrochloride and epinephrine hydrochloride, in asthmatics than in normal subjects.2 ;' Administration of the /5-blocking agent, propranolol hydrochloride, leads to increased airway resistance in asthmatic patients'; in patients with allergic ...

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Comparison of MAST With Radioallergosorbent and Skin Tests for Diagnosis of Allergy in Children

Ownby¹

1986

Arch Pediatr Adolesc Med

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The Impact of the Discovery of IgE on the Practice of Allergy

Cited by 12 publications

References 40 publications

Studies of the Radioallergosorbent Test and the Lymphocyte Stimulation Index in Symptomatic Ragweed Pollenosis

Studies of the Radioallergosorbent Test and the Lymphocyte Stimulation Index in Symptomatic Ragweed Pollenosis

Recent Advances in Bronchial Asthma

Comparison of MAST With Radioallergosorbent and Skin Tests for Diagnosis of Allergy in Children

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