The impact of solvent mixtures on neurobehavioral performance—Conclusions from epidemiological data

Meyer-Baron, Monika; Blaszkewicz, Meinolf; Henke, Henning; Knapp, Guido; Muttray, Axel; Schäper, Michael; Thriel, Christoph van

doi:10.1016/j.neuro.2008.02.005

Cited by 59 publications

(40 citation statements)

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“…Peripheral neuropathy of the radial nerves was found in workers exposed to the combination of white spirit, toluene, xylene, butyl acetate, and ethyl acetate 23 . RP can be trigged by stress, emotion, or anxiety at warm temperatures 24 , suggesting a role for the central nervous system in severe RP, and solvent exposure has been shown to cause central neurotoxicity 25 . People with RP were found to have impaired thermoregulation, with low core temperatures after cooling 26 .…”

Section: Journal Of Rheumatologymentioning

confidence: 99%

Raynaud’s Phenomenon in Medical Laboratory Workers Who Work with Solvents

Purdie

Purdie²,

Harrison³

2011

J Rheumatol

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Section: Journal Of Rheumatologymentioning

confidence: 99%

Raynaud’s Phenomenon in Medical Laboratory Workers Who Work with Solvents

Purdie

Purdie²,

Harrison³

2011

J Rheumatol

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“…Results obtained in studies using the case-control design for dementia [10][11][12] are limited due to the retrospective determination of exposures. A recent review highlighted the need for further studies with rigorous exposure descriptions, adjustment for important confounders, and cognitive tests sensitive in the detection of poor performance [13] . The GAZEL cohort allowed us to examine whether long-term occupational exposure to solvents is associated with poor cognitive performance on two tests in late midlife.…”

Section: Introductionmentioning

confidence: 99%

Occupational Exposure to Solvents and Cognitive Performance in the GAZEL Cohort: Preliminary Results

Berr

Vercambre

Bonenfant

et al. 2010

Dement Geriatr Cogn Disord

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Background: The impact of occupational exposure to solvents on cognitive ageing remains unclear. We examined whether long-term occupational exposure is associated with poor cognitive performance in late midlife. Methods: Participants in the GAZEL cohort, set up in 1989, are employees of the French national electricity and gas company. Data on the working environment were used to create measures of cumulative exposures to solvents using a job-exposure matrix. In 2002–2004, cognitive performance was assessed using the Digit Symbol Substitution Test (DSST) and the Mini Mental State Examination in 5,242 participants (aged 55–65 years). Results: In cross-sectional analysis using multiple logistic regression, there was a greater risk of poor cognitive performance (DSST score <25th percentile) among those with high exposure to benzene (OR = 1.58; 95% CI 1.31–1.90) and the grouped categories of chlorinated (OR = 1.39; 95% CI 1.3–2.3), aromatic (OR = 1.76; 95% CI 1.08–2.87), and petroleum solvents (OR = 1.50; 95% CI 1.23–1.81). Conclusions: These results suggest that occupational exposures to solvents may be associated later in life with cognitive impairment, even after taking into account the effects of education, employment grade, and numerous health factors.

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“…It is well established that occupational exposure to high levels of organic solvent in air may impair the functions of the central nervous system. [1][2][3] Threshold limit values have been set up in most developed countries, and high level exposures to solvents are expected to become less common. However, the neurotoxic effects of long-term, low-level exposure to organic solvents remain unclear.…”

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confidence: 99%

“…However, the neurotoxic effects of long-term, low-level exposure to organic solvents remain unclear. 2 Some studies in the past several decades have shown that low-level exposures to organic solvents were associated with poor cognitive and motor performance, 4-10 but the results were not always consistent. [11][12][13][14] Several reviews have criticized the methodological flaws of the individual studies, including small sample size, selection bias, poor choice of matching controls, and the lack of standardized neuropsychological assessment methods.…”

mentioning

confidence: 99%

“…[11][12][13][14] Several reviews have criticized the methodological flaws of the individual studies, including small sample size, selection bias, poor choice of matching controls, and the lack of standardized neuropsychological assessment methods. 2,[15][16][17][18] Therefore, although the volume of literature is great, the association between neurological dysfunction and prolonged low-level occupational exposure to solvents has remained a focus of research. The association between neurological dysfunction and prolonged low-level occupational exposure to solvents has remained a focus of research.…”

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Neurobehavioral Effects of Occupational Exposure to Organic Solvents Among Male Printing Workers in Hong Kong

Song¹,

Yu²,

Lao³

2013

Archives of Environmental & Occupational Health

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The objective of this study was to investigate the neurobehavioral effects of long-term occupational exposure to low levels of organic solvent among male printing workers in Hong Kong. A total of 115 printing workers exposed to organic solvents were recruited from the printing divisions of 3 printing factories, and 101 workers from the binding divisions of the same factories constituted the comparison group. Active and passive samplings were used to assess the occupational exposures to solvents. The World Health Organization Neurobehavioral Core Test Battery (WHO-NCTB) was applied to assess the neurobehavioral functions. Both active and passive sampling results showed that solvent levels were higher in the printing divisions than the binding divisions. The scores of Digit Symbol and Pursuit Aiming were poorer among workers in the printing divisions (all p values < .05). There were no significant differences found between the 2 divisions for other WHO-NCTB tests. The scores of Digit Symbol and Pursuit Aiming showed exposure-response relationship with various solvent exposure indices. Prolonged occupational exposure to low levels of organic solvents was associated with adverse neurobehavioral effects among male printing workers in Hong Kong.

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The impact of solvent mixtures on neurobehavioral performance—Conclusions from epidemiological data

Cited by 59 publications

References 54 publications

Raynaud’s Phenomenon in Medical Laboratory Workers Who Work with Solvents

Raynaud’s Phenomenon in Medical Laboratory Workers Who Work with Solvents

Occupational Exposure to Solvents and Cognitive Performance in the GAZEL Cohort: Preliminary Results

Neurobehavioral Effects of Occupational Exposure to Organic Solvents Among Male Printing Workers in Hong Kong

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