The Impact of Shiftwork on Skeletal Muscle Health

Aisbett, Brad; Condo, Dominique; Zacharewicz, Evelyn; Lamon, Séverine

doi:10.3390/nu9030248

Cited by 29 publications

(28 citation statements)

References 101 publications

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“…The present study provides further evidence that varying stimulation is important for skeletal muscle adaptation, as also suggested by human-based studies on interval training (31). Additionally, studies designed to understand muscle responses to various training modalities and to explore underlying mechanisms and influencing variables may assist in optimizing exercise interventions in humans for different outcomes in different settings (32,33).…”

Section: Discussionsupporting

confidence: 66%

Different continuous training modalities result in distinctive effects on muscle structure, plasticity and function

et al. 2020

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The effects of training on muscle structure are dependent on adaptive changes induced by different intensities of physical exercise. Evidence has shown that aerobic training is able to induce adaptive changes to muscle structure based on intensity. The aim of the present study was to investigate the effects of different methods of continuous aerobic training in mice using functional, morphological and biomolecular approaches. The continuous aerobic training methods used in the present study were uniform continuous training (UC), varying continuous training (VC) and progressive continuous training (PC). Mice were made to run 3 times a week for 12 weeks on a motorized RotaRod, following one of the three different training methods at different speeds. The results of the present study demonstrated that the various training methods had different effects on sarcomere length. Ultrastructural analysis demonstrated that UC training resulted in a shortening of sarcomere length, PC training resulted in an elongation of sarcomere length and VC training showed similar sarcomere length when compared with the control sedentary group. Additionally, succinate dehydrogenase complex flavoprotein subunit A levels in muscle tissue following VC training were higher compared with UC and PC training. Overall, the present study showed that varying exercise methods resulted in different types of muscle plasticity, and that the VC protocol resulted in increased coordination and strength endurance in the functional tests, in agreement with the ultrastructural and biochemical profile. These observations support the view that VC training may be more efficient in increasing performance and may thus form the basis of training regimens when an improvement of motor efficiency is required.

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Section: Discussionsupporting

confidence: 66%

Different continuous training modalities result in distinctive effects on muscle structure, plasticity and function

et al. 2020

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“…Populationbased studies report that the risk of developing these conditions is 15-30% higher in individuals who regularly experience sleep deprivation, sleep restriction, and inverted sleep-wake cycles (25,29,45). To this end, a growing body of evidence suggests that a lack of sleep may directly affect muscle protein metabolism (1,30,37). Rodent studies first demonstrated a possible causal link between complete sleep deprivation and disrupted muscle protein metabolism.…”

Section: Introductionmentioning

confidence: 99%

The effect of acute sleep deprivation on skeletal muscle protein synthesis and the hormonal environment

Lamon

Morabito

Arentson-Lantz

et al. 2020

Preprint

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AbstractSleep loss has profound, negative consequences on human tissues including skeletal muscle. Animal and human models suggest that acute and chronic sleep loss may directly impair muscle protein metabolism, which is critical to maintain muscle mass and function over the lifespan. This study aimed at providing a proof-of-concept that sleep deprivation acutely decreases muscle protein synthesis in humans. To this end, thirteen young males and females experienced one night of total sleep deprivation or slept normally at home. Anabolic and catabolic hormonal profiles, muscle fractional synthesis rate and markers of muscle protein degradation were assessed across the following day. In the sleep-deprived condition, cortisol release was 21% higher over a six-hour period (p=0.030). One night of complete sleep deprivation was however not sufficient to elicit significant changes in testosterone release (p=0.090) and muscle protein synthesis rates (p=0.081). Apparent sex-specific differences prompt the need for further dedicated investigations into the specific effects of total sleep deprivation on muscle protein metabolism in males and females.

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“…This may represent a potential model of sleep extension in the laboratory animal, which will open up the prospect of studies on the benefits of adding sleep as a prophylactic tool to limit deleterious consequences of sleep loss on health and tissue repair (Axelsson & Vyazovskiy, ). As an example, SD has been evidenced to impair skeletal muscle health (for review, see Aisbett, Condo, Zacharewicz, & Lamon, ), and there is a need to propose an integrated strategy to improve sleep in critical care units (Friese, ).…”

Section: Discussionmentioning

confidence: 99%

Lengthening of the photoperiod influences sleep characteristics before and during total sleep deprivation in rat

Sauvet¹,

Gomez-Mérino²,

Dorey³

et al. 2018

Journal of Sleep Research

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The photoperiod has been evidenced to influence sleep regulation in the rat. Nevertheless, lengthening of the photoperiod beyond 30 days seems to have little effect on the 24-hr baseline level of sleep and the response to total sleep deprivation. We studied the effects of 12:12 (habitual) and 16:8 (long) light-dark photoperiods on sleep, locomotor activity and body core temperature, before and after 24 hr of total sleep deprivation. Eight rats were submitted for 14 days to light-dark 12:12 (lights on: 08:00 hours-20:00 hours) followed by total sleep deprivation, and then for 14 days to light-dark 16:8 (light extended to 24:00 hours) followed by total sleep deprivation. Rats were simultaneously recorded for electroencephalogram, locomotor activity and body core temperature for 24 hr before and after total sleep deprivation. At baseline before total sleep deprivation, total sleep time and non-rapid eye movement sleep per 24 hr and during extended light hours (20:00 hours-24:00 hours) were higher (13% for total sleep time) after light-dark exposure compared with habitual photoperiod, while percentage delta power in non-rapid eye movements and rapid eye movements were unchanged. Locomotor activity and body core temperature were lower, particularly during extended light hours (20:00 hours-24:00 hours). Following total sleep deprivation, total sleep time and non-rapid eye movements were significantly lower after long photoperiod between 20:00 hours and 24:00 hours, and between 10:00 hours and 12:00 hours, and unchanged per 24 hr. The percentage delta power in non-rapid eye movements was lower between 08:00 hours and 11:00 hours. Total sleep deprivation decreased locomotor activity and body core temperature after habitual photoperiod exposure only. Fourteen days under long photoperiod (light-dark 16:8) increased non-rapid eye movements sleep, and decreased sleep rebound related to total sleep deprivation (lower non-rapid eye movements duration and delta power). This may create a model of sleep extension for the rat that has been found to favour anabolism in the brain and the periphery.

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The Impact of Shiftwork on Skeletal Muscle Health

Cited by 29 publications

References 101 publications

Different continuous training modalities result in distinctive effects on muscle structure, plasticity and function

Different continuous training modalities result in distinctive effects on muscle structure, plasticity and function

The effect of acute sleep deprivation on skeletal muscle protein synthesis and the hormonal environment

Lengthening of the photoperiod influences sleep characteristics before and during total sleep deprivation in rat

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