The skin is the largest organ of the body and acts as a defensive barrier against microorganismal, chemical, and physical attack while protecting homeostasis of the internal environment. Disruption of this barrier plays an important role in the pathogenesis of some dermatoses and sensitive skin. Sensitive skin (cosmetic intolerance syndrome) is a widespread dermatological problem and is used as a universal language in the field of cosmetology. The global prevalence of sensitive skin is around 60%-70% in females and 50%-60% in males. [1][2][3] Sensitive skin is defined as the emergence of unpleasant sensations (stinging, burning, pain, itching, and tingling sensation) in