The impact of SARS-CoV2 vaccines on the incidence of graft versus host disease in allogeneic hematopoietic stem cell transplant recipients: a single-center retrospective study

Ngo, Dat; Chen, Jason; Tinajero, Jose; Aribi, Ahmed; Arslan, Shukaib; Marcucci, Guido; Nakamura, Ryotaro; Malki, Monzr M. Al; Forman, Stephen J.; Dadwal, Sanjeet; Ali, Haris

doi:10.1186/s13287-023-03326-3

Cited by 3 publications

(4 citation statements)

References 8 publications

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“…Both uveitis and GVHD have been reported respectively after vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [ 5 , 6 ]. Nevertheless, the simultaneous occurrence of ocular GVHD and anterior uveitis in recipients of HSCT after COVID-19 vaccination is rare and has not been extensively discussed in previous literature.…”

Section: Discussionmentioning

confidence: 99%

“…Among these cases, the ocular presentation accounted for approximately 20%. Previous chronic GVHD and transplant dates less than 180 days were associated to a higher rate of GVHD [ 5 ]. Andrew et al reported that in allogeneic HSCT recipients with chronic GVHD, the occurrence of symptom exacerbation following COVID-19 vaccination was relatively common (26.5%) [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, the safety and efficacy of these vaccines in patients after allogeneic HSCT are still under investigation [ 4 ]. With regard to the sequelae of COVID-19 vaccination, Charlotte reported the classification and rates of uveitis, and Dat Ngo specifically discussed GVHD [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Acute exacerbation of ocular graft-versus-host disease and anterior uveitis after COVID-19 vaccination

Lin,

Chien

2023

BMC Ophthalmol

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Background To report a case of simultaneous occurrence of acute exacerbation of ocular graft-versus-host disease (GVHD) and anterior uveitis following coronavirus disease 2019 (COVID-19) vaccination. Case presentation A 60-year-old man with primary myelofibrosis and GVHD after receiving allogeneic hematopoietic stem cell transplantation (HSCT), developed acute exacerbation of ocular GVHD and anterior uveitis after receiving first dose of COVID-19 vaccine. The patient developed erythema of the eyelids, conjunctival hyperemia, superficial punctate keratopathy, and prominent anterior chamber inflammation in both eyes. The ocular GVHD and anterior uveitis were managed with mainly topical corticosteroids, antibiotics, lubricants, and systemic corticosteroids, but were difficult to control. Intravitreal injection of dexamethasone was administered, and the inflammation gradually subsided 6 months after the onset of initial symptoms. Conclusions Clinicians should be aware of rare refractory anterior uveitis and acute exacerbation of ocular GVHD after COVID-19 vaccination in patients undergoing HSCT. Early diagnosis and aggressive treatment should be considered to reduce the likelihood of severe complications.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Acute exacerbation of ocular graft-versus-host disease and anterior uveitis after COVID-19 vaccination

Lin,

Chien

2023

BMC Ophthalmol

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“…In multivariate analysis, previous chronic GVHD and recent transplantation are associated with a higher incidence of GVHD after COVID-19 vaccination . 21 , 22 …”

Section: Discussionmentioning

confidence: 99%

Acute intestinal GVHD following donor-derived CD7-CAR-T-cell infusion in a child with Omicron COVID-19

Lian,

Gao,

et al. 2023

Blood Science

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Recent infection with SARS‐CoV‐2 in donors was associated with a higher incidence of acute graft‐versus‐host disease in recipients undergoing allogeneic haematopoietic stem cell transplantation

Lin,

Xu,

Han

et al. 2024

Br J Haematol

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SummaryThe global pandemic has resulted in the common occurrence of SARS‐CoV‐2 infection in the population. In the post‐pandemic era, it is imperative to understand the influence of donor SARS‐CoV‐2 infection on outcomes after allogeneic haematopoietic stem cell transplantation (allo‐HSCT). We retrospectively analysed allo‐HSCTs from donors with mild SARS‐CoV‐2 infection or early recovery stage (ERS) (group 1, n = 65) and late recovery stage (group 2, n = 120). Additionally, we included allo‐HSCT from donors without prior SARS‐CoV‐2 infection as group 0 (n = 194). Transplants from donors with different SARS‐CoV‐2 infection status had comparable primary engraftment and survival rates. However, group 1 had higher incidences of acute graft‐versus‐host disease (aGvHD), grade II–IV (41.5% vs. 28.1% in group 0 [p = 0.014] and 30.6% in group 2 [p = 0.067]) and grade III–IV (22.2% vs. 9.6% [p = 0.004] in group 0 and 12.2% in group 2 [p = 0.049]). Conversely, the risk of aGvHD in group 2 was similar to that in group 0 (p > 0.5). Multivariable analysis identified group 1 associated with grade II–IV (hazard ratio [HR] 2.307, p = 0.010) and grade III–IV (HR 2.962, p = 0.001) aGvHD, which yielded no significant risk factors for survival. In conclusion, we preliminarily demonstrated donors in the active infection state or ERS of mild SARS‐CoV‐2 infection were associated with higher incidences of aGvHD in transplants from related donors.

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The impact of SARS-CoV2 vaccines on the incidence of graft versus host disease in allogeneic hematopoietic stem cell transplant recipients: a single-center retrospective study

Cited by 3 publications

References 8 publications

Acute exacerbation of ocular graft-versus-host disease and anterior uveitis after COVID-19 vaccination

Acute exacerbation of ocular graft-versus-host disease and anterior uveitis after COVID-19 vaccination

Acute intestinal GVHD following donor-derived CD7-CAR-T-cell infusion in a child with Omicron COVID-19

Recent infection with SARS‐CoV‐2 in donors was associated with a higher incidence of acute graft‐versus‐host disease in recipients undergoing allogeneic haematopoietic stem cell transplantation

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