Acute exacerbation of ocular graft-versus-host disease and anterior uveitis after COVID-19 vaccination

Lin, Chen-Yu; Chien, Hung-Jen

doi:10.1186/s12886-023-03103-z

Cited by 1 publication

(2 citation statements)

References 14 publications

(17 reference statements)

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“…Although an increased incidence of GVHD was not observed during the COVID-19 period in this study, COVID-19 may trigger a profound inflammatory response, which can exacerbate cytokine release, potentially leading to the onset or increased severity of GVHD. 24 Additionally, “long-COVID-19” symptoms and other post-acute sequelae have been described in literature, hence longer follow-up is required to understand the long-term impact of COVID-19 on our patients. 25 …”

Section: Discussionmentioning

confidence: 97%

“…COVID-19 period in this study, COVID-19 may trigger a profound inflammatory response, which can exacerbate cytokine release, potentially leading to the onset or increased severity of GVHD. 24 Additionally, "long-COVID-19" symptoms and other post-acute sequelae have been described in literature, hence longer follow-up is required to understand the long-term impact of COVID-19 on our patients. 25 The high incidence of COVID-19 among pediatric HSCT patients raises the question of whether they should vaccinated against SARS-CoV-2.…”

mentioning

confidence: 98%

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Surveillance and Outcomes of Pediatric Hematopoietic Stem Cell Transplantation Recipients During the Recent COVID-19 Outbreak in China

Wang,

Yu,

Ding

et al. 2023

IDR

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Background The COVID-19 pandemic presents challenges for healthcare systems globally, especially in vulnerable populations such as pediatric hematopoietic stem cell transplant (HSCT) recipients. This study examines the clinical characteristics and outcomes of COVID-19 infection in pediatric HSCT recipients within one year post-HSCT. Methods Retrospective analysis was conducted on data from 247 pediatric patients. None of them had received SARS-CoV-2 vaccination or had prior infection. SARS-CoV-2 infection was confirmed using RT-PCR testing. COVID-19 disease severity was categorized according to established guidelines. Demographic, clinical, laboratory, imaging and treatment data were collected. Results The median age of the cohort was 7±3.7 years, with thalassemia major as the predominant underlying disease. Allogeneic HSCT was performed in the majority of cases, with haploidentical donors being the most common source of grafts. Nearly half of the patients developed COVID-19, with significantly higher infection rates observed in recipients over 100 days compared to recipients within 100 days post-HSCT (40.1% vs 21.7%, p <0.05, Fisher’s Exact test). Fever (n=107, 43.2%) and cough (n=88, 35.6%) were the most common symptoms. While most patients had mild disease and did not require specific anti-viral treatment, a significant proportion required hospitalization (n=34, 13.8%). Various treatments were employed hospitalized patients, including Paxlovid (n=19, 55.9%), methylprednisolone (n=7, 20.6%), IL-6 antibody (n=2, 5.9%), mesenchymal stem cells (n=3, 8.8%), and exosomes nebulization therapy (n=2, 5.9%). Despite multidisciplinary approaches, one patient died from severe respiratory failure. However, overall survival of all patients remained high (99.53%; CI 96.72–99.93%), indicating favorable outcomes in pediatric HSCT recipients with COVID-19. Conclusion This study provides insights into clinical features, therapeutic measures, and outcomes of pediatric HSCT recipients following COVID-19 infection in a large HSCT center in China. These findings contribute to our understanding of COVID-19 in this population and inform strategies to mitigate the impact the pandemic’s impact on their care.

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Section: Discussionmentioning

confidence: 97%

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confidence: 98%