The Impact of SARS-CoV-2 Infection on Fertility and Female and Male Reproductive Systems

Markiewicz-Gospodarek, Agnieszka; Wdowiak, Paulina; Czeczelewski, Marcin; Forma, Alicja; Flieger, Jolanta; Januszewski, Jacek; Radzikowska-Büchner, Elżbieta; Baj, Jacek

doi:10.3390/jcm10194520

Cited by 10 publications

(8 citation statements)

References 106 publications

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“…However, to our knowledge, there are no studies demonstrating an endometrial susceptibility to the virus ( Henarejos-Castillo et al, 2020 ). Nevertheless, since ACE2 endometrial localization has been positively correlated with age, it has been suggested an age-related endometrial predisposition to viral infection ( Abhari and Kawwass, 2020 ; Markiewicz-Gospodarek et al, 2021 ). Of interest, SARS-Cov-2 encodes proteins able to activate the assembly of inflammasome NLRP3 ( Man et al, 2017 ; Lee et al, 2020 ).…”

Section: The Impact Of Severe Acute Respiratory Syndrome Coronavirus-...mentioning

confidence: 99%

Is There a Role for SARS-CoV-2/COVID-19 on the Female Reproductive System?

et al. 2022

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Coronavirus disease (COVID-19) has emerged as a very serious pandemic caused by the rapidly evolving transmission of the coronavirus SARS-CoV-2. Since its outbreak in 2020, the SARS CoV-2 has represented an important challenge for the physicians due to its well known respiratory sequelae. To date, the role of SARS-CoV-2 infection on organs and systems other than lungs and respiratory tract remains less clear. In particular, it remains to be investigated whether the reproductive system can be affected by the SARS-CoV-2 in the long term-period or, in alternative, drugs used to treat COVID-19 might impact the reproductive systems and, in turn, fertility. What is known is that SARS-Cov-2 binds to target cells of host through different receptors including angiotensin-converting enzyme 2 (ACE2), neuropilin-1, AXL and antibody-FcɣR complexes. ACE2 physiologically regulates both the expression of angiotensin II (Ang II) as well as Ang-(1-7) to exerts its physiological functions. The reproductive system abundantly expresses ACE2 and produces Ang-(1-7), starting from precursors which are locally generated or derived from systemic circulation. Ang-(1-7) plays an important role of stimulus to the growth and maturation of ovarian follicle as well as to ovulation. Also human endometrium expresses Ang-(1-7), mainly during the post-ovulatory phase. Animal and human observational studies demonstrated that Ang-(1-7) is involved in the maternal immune response to pregnancy and its deficiency is associated with a defective placenta development. In our manuscript, we review the current knowledge about whether SARS-CoV-2 may impact the female reproductive system. We further explain the possible molecular mechanism by which SARS-CoV-2 might affect ovarian, endometrial and female genital tract cells.

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Section: The Impact Of Severe Acute Respiratory Syndrome Coronavirus-...mentioning

confidence: 99%

Is There a Role for SARS-CoV-2/COVID-19 on the Female Reproductive System?

et al. 2022

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“…[2] Besides, COVID-19 has multi-faceted impacts on women's infertility, including sex hormones, reproductive organs, and the physiology of pregnancy. [3] Most reproductive treatments had to be halted worldwide due to the COVID-19 outbreak. [4] However, according to studies, the great majority of people struggling with infertility chose to continue their therapy whenever there was a possibility.…”

Section: Introductionmentioning

confidence: 99%

Impact of vaccination against COVID-19 on the outcomes of in vitro fertilization–embryo transfer: a retrospective cohort study

Yin

Wang

Tao

et al. 2023

Chinese Medical Journal

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Background:Vaccination against coronavirus disease 2019 (COVID-19) has become the primary approach in the fight against the spread of COVID-19. Studies have shown that vaccination against COVID-19 has adverse effects, particularly on human reproductive health, despite the fact that vaccination rates are still on the rise. However, few studies have reported whether vaccination affects the outcome of in vitro fertilization–embryo transfer (IVF–ET) or not. In this study, we compared the outcome of IVF–ET and the development of follicles and embryos between vaccinated and unvaccinated groups.Methods:A single-center retrospective cohort study of 10,541 in vitro fertilization (IVF) cycles was conducted from June 2020 to August 2021. 835 IVF cycles with a history of vaccination against COVID-19 and 1670 IVF cycles that served as negative controls were selected and analyzed utilizing the Matchlt package of R software (http://www.R-project.org/) and the nearest neighbor matching algorithm for propensity-matched analysis at a 1:2 ratio.Results:The number of oocytes collected in the vaccinated group and the unvaccinated group were 8.00 (0, 40.00) and 9.00 (0, 77.00) (P = 0.073) and the good-quality embryo rates of the two groups were 0.56±0.32 and 0.56±0.31 averagely (P = 0.964). Clinical pregnancy rates for the vaccinated group and unvaccinated group were 42.4% (155/366) and 40.2% (328/816) (P = 0.486) and biochemical pregnancy rates were 7.1% (26/366) and 8.7% (71/816) (P = 0.355). Two other factors were analyzed in this study; vaccination among different genders and different types (inactivated vaccine or recombinant adenovirus vaccine) showed no statistically significant effect on the above outcomes.Conclusions:In our findings, vaccination against COVID-19 showed no statistically significant effect on the outcomes of IVF-ET and the development of follicles and embryos, nor did the gender of the vaccinated person or the formulation of vaccines show significant effects.

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“…Through its impact on the central nervous system, SARS-CoV-2 is hypothesized to affect fertility [ 135 ] indirectly. Gonadotropins and sex steroid hormones act to synchronize the brain and testes physiologically.…”

Section: Sars-cov-2 and Its Impact On The Brain Leading To Infertilitymentioning

confidence: 99%

Insights into the Scenario of SARS-CoV-2 Infection in Male Reproductive Toxicity

et al. 2023

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COVID-19 has become a significant public health concern that has catastrophic consequences for society. Some preliminary evidence suggests that the male reproductive system may be an infection target for SARS-CoV-2. SARS-CoV-2 may be transmitted sexually, according to preliminary research. Testicular cells exhibit a high level of the angiotensin-converting enzyme 2 (ACE2) receptor, which enhances the entry of the SARS-CoV-2 into host cells. Some instances of COVID-19 have been documented to exhibit hypogonadism during the acute stage. Furthermore, systemic inflammatory reactions triggered by SARS-CoV-2 infection may cause oxidative stress (OS), which has been shown to have profoundly deleterious consequences on testicular functioning. This work gives a clear picture of how COVID-19 may affect male reproductive systems and calls attention to the many unanswered questions about the mechanisms by which this virus can be linked to men’s health and fertility.

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The Impact of SARS-CoV-2 Infection on Fertility and Female and Male Reproductive Systems

Cited by 10 publications

References 106 publications

Is There a Role for SARS-CoV-2/COVID-19 on the Female Reproductive System?

Is There a Role for SARS-CoV-2/COVID-19 on the Female Reproductive System?

Impact of vaccination against COVID-19 on the outcomes of in vitro fertilization–embryo transfer: a retrospective cohort study

Insights into the Scenario of SARS-CoV-2 Infection in Male Reproductive Toxicity

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