The impact of sarcopenic obesity on inflammation, lean body mass, and muscle strength in elderly women

Nascimento, Dahan da Cunha; Oliveira, Samuel da Cunha; Vieira, Denis César Leite; Funghetto, Silvana Schwerz; Silva, Alessandro Oliveira; Valduga, Renato; Schöenfeld, Brad J.; Prestes, Jonato

doi:10.2147/ijgm.s187285

Cited by 21 publications

(12 citation statements)

References 33 publications

(62 reference statements)

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“…In our analysis, patients presented similar ages in the OLMM and ONMM groups. BMI was higher in the OLMM group by ASM/BMI, while BMI was negatively correlated with ASM/wt × 100, as well as for ASM/BMI, similarly to another study 25. In addition, the ASM/wt × 100 and ASM/BMI had a negative influence on body mass and were adequate for evaluating LMM in obese individuals.…”

Section: Discussionsupporting

confidence: 78%

<p>Relationship Between Skeletal Muscle Mass Indexes and Muscular Function, Metabolic Profile and Bone Mineral Density in Women with Recommendation for Bariatric Surgery</p>

Carvalho

Martins

Filho

et al. 2019

DMSO

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Background and aim: We evaluated low skeletal muscle mass (LMM) in women prior to bariatric surgery (BS) through different skeletal muscle mass indexes (MMIs) regarding body fat percentage (BFP), handgrip strength (HS), six-minute walk test (6MWT), metabolic profile and bone mineral density (BMD). Methods: Women (n=62) were allocated into two groups according to LMM: obesity with low muscle mass (OLMM) or obesity with normal muscle mass (ONMM). LMM was defined by the appendicular skeletal muscle mass (ASM) adjusted for weight (ASM/wt × 100) and ASM adjusted for body mass index (ASM/BMI), considering the lowest quintile of the indexes studied. Results: OLMM was found in 30.5% by ASM/wt × 100 and 20.3% by ASM/BMI. Using the ASM/wt × 100, OLMM group had a high BFP, low HS and BMD in L1-L4, femoral neck (FN) and total femur (TF) when compared with ONMM (p < 0.05). Using ASM/BMI, OLMM group had increased BFP, reduced HS and 6MWT in comparison to ONMM (p < 0.05). Metabolic profile was similar between OLMM and ONMM groups by the two MMIs. MMIs were negatively correlated with BFP (p < 0.05) and positively correlated with HS (p < 0.05), and none of them with 6MWT (p > 0.05). ASM/wt × 100 was positively correlated with all BMD sites assessed (p < 0.05). There was positive correlation between ASM/wt × 100 and ASM/BMI. Conclusion: OLMM identified by the ASM/wt × 100 and ASM/BMI had higher adiposity and lower HS. Using ASM/BMI, we found that OLMN had a poor physical performance, while the ASM/wt × 100 identified a lower BMD at all sites.

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Section: Discussionsupporting

confidence: 78%

<p>Relationship Between Skeletal Muscle Mass Indexes and Muscular Function, Metabolic Profile and Bone Mineral Density in Women with Recommendation for Bariatric Surgery</p>

Carvalho

Martins

Filho

et al. 2019

DMSO

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“…Importantly, as skeletal muscle plays a critical role in glycaemic control and metabolic homeostasis (74,75), the combination of a loss of lean body mass and a concomitant increase in visceral adiposity will likely exacerbate the risk of developing metabolic disease, particularly in the older adult, accelerating skeletal muscle deterioration, reduced physical performance, an increased risk for disability, hospitalizations, morbidity, and early mortality (76)(77)(78). The development of sarcopenic-obesity is thought to be brought about by a combination of factors that contribute to the development of both conditions (21) and is associated with significantly greater body fat, oxidative stress and inflammation and intracellular lipotoxicity, glucose and endocrine dysregulation, as well as impaired muscle strength and lower lean body mass (63,66,(79)(80)(81). Further, when obesity and impaired muscle function co-exist, they act synergistically in a "vicious cycle" on the risk of developing multiple health-related outcomes (19,21,42,(82)(83)(84).…”

Section: Diagnosis and Prevalence Of Sarcopenic-obesitymentioning

confidence: 99%

Exploring the Impact of Obesity on Skeletal Muscle Function in Older Age

2020

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Sarcopenia is of important clinical relevance for loss of independence in older adults. The prevalence of obesity in combination with sarcopenia (“sarcopenic-obesity”) is increasing at a rapid rate. However, whilst the development of sarcopenia is understood to be multi-factorial and harmful to health, the role of obesity from a protective and damaging perspective on skeletal muscle in aging, is poorly understood. Specifically, the presence of obesity in older age may be accompanied by a greater volume of skeletal muscle mass in weight-bearing muscles compared with lean older individuals, despite impaired physical function and resistance to anabolic stimuli. Collectively, these findings support a potential paradox in which obesity may protect skeletal muscle mass in older age. One explanation for these paradoxical findings may be that the anabolic response to weight-bearing activity could be greater in obese vs. lean older individuals due to a larger mechanical stimulus, compensating for the heightened muscle anabolic resistance. However, it is likely that there is a complex interplay between muscle, adipose, and external influences in the aging process that are ultimately harmful to health in the long-term. This narrative briefly explores some of the potential mechanisms regulating changes in skeletal muscle mass and function in aging combined with obesity and the interplay with sarcopenia, with a particular focus on muscle morphology and the regulation of muscle proteostasis. In addition, whilst highly complex, we attempt to provide an updated summary for the role of obesity from a protective and damaging perspective on muscle mass and function in older age. We conclude with a brief discussion on treatment of sarcopenia and obesity and a summary of future directions for this research field.

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“…Thus, the gap in SUA between genders narrowed, which may neutralize the difference in the relationship of hyperuricemia and low SMM association between genders. In addition, adipose accumulation increases the burden of insulin resistance and inflammation and can lead to skeletal muscle loss [44]; it is evident that women have a higher percentage of body fat than age-matched men.…”

Section: Discussionmentioning

confidence: 99%

Hyperuricemia Associated with Low Skeletal Muscle in the Middle-Aged and Elderly Population in China

Chen

et al. 2022

Exp Clin Endocrinol Diabetes

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Background Previous studies have presented inconsistent results on the relationship between serum uric acid and skeletal muscle mass (SMM). We aimed to explore whether a higher serum uric acid level was associated with low SMM in the Chinese population. Methods We performed a cross-sectional analysis of 6595 subjects aged 45 years or older. They were tested for fasting blood glucose, total cholesterol, triglycerides, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, uric acid, blood urea nitrogen, creatinine, and estimated glomerular filtration rate. SMM was accessed by dual-energy x-ray absorptiometry using two approaches: weight-adjusted appendicular skeletal muscle mass (ASM)% and ASM/BMI (body mass index (kg/m2)). Low SMM was defined as a cut-off point of ASM/BMI<0.789 for men and<0.512 for women. Results Compared with their normal group, patients with hyperuricemia had lower ASM% (29.33±2.33 vs 30.03±2.34 for males and 24.71±1.99 vs 25.19±2.07 for females, P<0.01) and ASM/BMI (0.83±0.10 vs 0.85±0.10 for male and 0.60±0.07 vs 0.62±0.07 for female), with a higher prevalence of the associated low SMM in both sexes (35.2 vs 26.5% for male and 10.5 vs 5.9% for female, P<0.01). Pearson analysis showed that ASM% and ASM/BMI were negatively correlated with SUA (male: ASM/BMI, r=−0.097, ASM%, r=−0.146; female: ASM/BMI, r=−0.151, ASM%, r=−0.157; all P<0.001). Logistic regression analysis showed a positive association of hyperuricemia with adjusted risk of low SMM association. Conclusions In a middle-aged and elderly Chinese population, hyperuricemia is independently and positively associated with low SMM and can vary by age and gender.

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The impact of sarcopenic obesity on inflammation, lean body mass, and muscle strength in elderly women

Cited by 21 publications

References 33 publications

<p>Relationship Between Skeletal Muscle Mass Indexes and Muscular Function, Metabolic Profile and Bone Mineral Density in Women with Recommendation for Bariatric Surgery</p>

<p>Relationship Between Skeletal Muscle Mass Indexes and Muscular Function, Metabolic Profile and Bone Mineral Density in Women with Recommendation for Bariatric Surgery</p>

Exploring the Impact of Obesity on Skeletal Muscle Function in Older Age

Hyperuricemia Associated with Low Skeletal Muscle in the Middle-Aged and Elderly Population in China

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