&lt;p&gt;Relationship Between Skeletal Muscle Mass Indexes and Muscular Function, Metabolic Profile and Bone Mineral Density in Women with Recommendation for Bariatric Surgery&lt;/p&gt;

Carvalho, Nara Nóbrega Crispim; Martins, Vinícius Gomes; Filho, João Aragão Ximenes; Bandeira, Francisco; Pimenta, Flávia Cristina Fernandes; Alves, José Luiz de Brito

doi:10.2147/dmso.s213643

Cited by 7 publications

(6 citation statements)

References 41 publications

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“…In the present study, we observed that the mean 6MWD in the total sample and the mean 6MWD in the class 3 obesity group were 428.3±85.7 m and 417.3±76.4 m, respectively. These values were slightly higher than those reported by Crispim Carvalho et al ( 20 ) in 62 obese women aged 24-57 years but close to those observed by Vargas et al ( 21 ) in a cohort of 67 obese individuals, including 61 (91%) women and 6 (9%) men, with a mean age of 38±10 years. Differences in the metabolic profile of the sampled population, the type and frequency of incentives, and the length of the corridor may explain the differences reported in 6MWD; therefore, these factors should be considered when interpreting the results ( 21 ).…”

Section: Discussionsupporting

confidence: 80%

Contribution of lung function in predicting distance covered in the 6-min walk test in obese Brazilian women

Luchesa

Mafort

Silva

et al. 2020

Braz J Med Biol Res

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Obesity affects the respiratory system through various mechanisms, including systemic inflammation and direct mechanical hindrance due to fat deposition in the chest and abdomen. In addition, changes in the neural control of respiration and increases in thoracic blood volume can promote abnormalities in lung function. Thus, determining relationships between the distance covered in the 6-min walk test (6MWT) and demographic and lung function variables may help us better understand the mechanisms involved in reduced functional exercise capacity in obesity. To explore the determinants of the 6-min walking distance (6MWD) and evaluate the influence of lung function on the distance covered, 263 obese Brazilian women performed the 6MWT and underwent spirometry and respiratory muscle strength measurement. The mean age was 41.8±11.1 years. The mean body mass index (BMI) was 45±8 kg/m 2 . The 6MWD showed correlations with height (r=0.319), age (r=-0.281), weight (r=-0.370), BMI (r=-0.561), forced vital capacity (FVC, r=0.443), expiratory peak flow (r=0.278), maximal inspiratory pressure (MIP, r=0.326), and maximal expiratory pressure (r=0.259), all with P<0.0001. In the stepwise forward regression analysis, BMI, FVC, age, and MIP were the independent predictive variables for 6MWD, explaining 41% of its variability. The reference equation including lung function was as follows: 6MWD (m) = 513.6 - (4.439 × BMI kg/m2 ) + (1.136 × FVC %predicted ) - (1.048 × age yrs ) + (0.544 × MIP %predicted ). Thus, the inclusion of lung function in a reference equation for 6MWD contributes to a better prediction of the distance covered in this population.

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Section: Discussionsupporting

confidence: 80%

Contribution of lung function in predicting distance covered in the 6-min walk test in obese Brazilian women

Luchesa

Mafort

Silva

et al. 2020

Braz J Med Biol Res

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“…Despite the importance of the 6 MWT, research on its value for the obese population is limited. In addition, almost all previous studies involving the 6 MWT have been performed in samples predominantly composed of obese women, who have very different performance from that observed in obese men during submaximal exercise [ 3 , 6 , 11 , 19 , 21 ]. Similar to Wooldridge et al [ 4 ], Vanhelst et al [ 22 ], and Hulens et al [ 23 ], we observed that BMI was one of the most important variables in the reference equation for the 6 MWD of obese subjects, which is not surprising because excess weight increases the workload and affects walking due to trunk oscillation and the increased distance between the feet [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

Reference Value for the Distance Walked in the Six-Minute Walk Test in Obese Brazilian Men in the Preoperative Period of Bariatric Surgery

et al. 2021

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Background. Obesity has several effects on the mechanics of the rib cage that may impair the exercise performance of obese individuals and therefore impact the assessment of surgical risk. This study aimed to establish a reference value for the 6-minute walk distance (6 MWD) in obese Brazilian men in the preoperative period of bariatric surgery that considers the effect of lung function. Methods. This was a cross-sectional study in which 104 obese men underwent the six-minute walk test (6 MWT) before bariatric surgery. They also underwent the spirometry test and respiratory muscle strength measurement before the 6 MWT. Results. The 6 MWD was correlated with age (r = −0.388, p = 0.0005 ), weight (r = −0.365, p = 0.0007 ), height (r = 0.285, p = 0.022 ), body mass index (BMI) (r = −0.543, p < 0.0001 ), forced vital capacity (FVC) (r = 0.472, p < 0.0001 ), peak expiratory flow (r = 0.253, p = 0.031 ), and maximal inspiratory pressure (r = 0.313, p = 0.017 ). In the stepwise forward regression analysis, BMI, FVC, and age were the only variables that independently predicted the 6 MWD and explained 40% of its variability. The reference equation proposed for obese Brazilian men is 6 MWD (m) = 570.5 − (3.984 × BMIkg/m2) + (1.093 × FVC%predicted) − (0.836 × ageyrs). Conclusion. In this sample of obese Brazilian men, lung function contributed to poor performance in the 6 MWT. In these individuals, BMI, FVC, and age were the variables that composed the reference equation for the 6 MWD. Thus, in several clinical settings, such as in the evaluation before bariatric surgery, pulmonary function data are important to determine the reference value for the 6 MWD.

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“…However, without previous studies, it is difficult to draw some parallel [56]. Different clinical outcomes, such as increased risk of developing metabolic syndrome, difficulties in performing daily living activities of and mortality are related to muscle mass and low quality of muscle functions [35,68,69]. Recent evidence shows that low quality muscle mass is associated with the development of frailty in obese individuals [70].…”

Section: Discussionmentioning

confidence: 99%

What are the factors associated with sarcopenia-related variables in adult women with severe obesity?

et al. 2020

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Background: Understanding the association between sarcopenia-related variables and several risk factors may help to implement interventions aimed at preventing its occurrence by reducing or controlling the identified risk factors. Although changes in body composition occur in both sexes, in women, muscle loss is accentuated due to decreased estrogen levels following menopause. This study aims to determine the factors associated with sarcopenia-related parameters in middle-aged women identified with class II/III obesity (body mass index [BMI] ≥ 35 kg/m 2). Methods: The study included 104 women with severe obesity (40.23 ± 8.49 years) with an average body fat percentage of 52.45 ± 4.14%. Sarcopenia was assessed using total appendicular skeletal muscle mass (ASMM), appendicular skeletal muscle mass index (ASMMI), and appendicular skeletal muscle mass adjusted by BMI (ASMM/BMI) as evaluated using dual energy X-ray absorptiometry (DXA). Hand grip strength (HGS) and HGS adjusted by BMI (HGS/BMI) were evaluated using dynamometry. Functional performance was assessed using the walking speed test (WS). The explanatory variables were age, lifestyle, comorbidities, food consumption, and metabolic parameters. A multivariate linear regression was performed. Results: Factors associated with sarcopenia-related variables in 104 severely obese women with a mean BMI of 43.85 kg/ m 2 were as follows: ASMMI negatively correlated with serum levels of tetraiodothyronine (T4) and tobacco use; ASMM/ BMI negatively correlated with age, serum T4 levels, and diabetes; ASMM negatively correlated with T4 serum levels and diabetes; HGS negatively correlated with age and hypercholesterolemia, and positively correlated with low-density lipoprotein cholesterol (LDL-c); HGS/BMI negatively correlated with age and hypercholesterolemia and positively correlated with LDL-c; and WS negatively correlated with hypothyroidism and diabetes. Conclusion: In severely obese women, muscle mass and function were inversely associated with age, smoking status, endocrine parameters, hypercholesterolemia, and comorbidities such as diabetes. Thus, the results of this investigation are relevant in supporting the development of clinical interventions to aid in the prevention of sarcopenia in adult women with severe obesity.

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<p>Relationship Between Skeletal Muscle Mass Indexes and Muscular Function, Metabolic Profile and Bone Mineral Density in Women with Recommendation for Bariatric Surgery</p>

Cited by 7 publications

References 41 publications

Contribution of lung function in predicting distance covered in the 6-min walk test in obese Brazilian women

Contribution of lung function in predicting distance covered in the 6-min walk test in obese Brazilian women

Reference Value for the Distance Walked in the Six-Minute Walk Test in Obese Brazilian Men in the Preoperative Period of Bariatric Surgery

What are the factors associated with sarcopenia-related variables in adult women with severe obesity?

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