The Impact of Reward, Punishment, and Frustration on Attention in Pediatric Bipolar Disorder

Rich, Brendan A.; Schmajuk, Mariana; Pérez‐Edgar, Koraly; Pine, Daniel S.; Leibenluft, Ellen

doi:10.1016/j.biopsych.2005.01.006

Cited by 107 publications

(116 citation statements)

References 49 publications

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“…During an emotional face-processing task, adolescents with bipolar disorder reported greater hostility in neutral faces than did controls and overall demonstrated increased subcortical activity to emotional faces [49] compared with healthy controls. This supports findings of impaired social cognition and response flexibility in euthymic adolescents with bipolar disorder [53].…”

Section: Pediatric Bipolar Disordermentioning

confidence: 93%

See 1 more Smart Citation

Neuroimaging in bipolar disorder: A critical review of current findings

Keener

Phillips²

2007

Curr Psychiatry Rep

102

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Bipolar I disorder (BPI) is among the top 10 most debilitating illnesses globally. In this critical review, we first review recent functional neuroimaging findings in two core domains of pathology in BPI: emotion processing and executive control. These abnormalities in core domains represent potential endophenotypes of the illness. We then show that an emerging number of studies have demonstrated that neuroimaging can help to identify endophenotypic markers whose identification would help to clarify diagnosis and discriminate the depression in BPI from that of unipolar depression and identify at-risk individuals who will subsequently develop the illness (to facilitate early intervention). We end by reviewing the new directions in neuroimaging in BPI, including studies of children with bipolar disorder, potential medication effects, and the use of newer neuroimaging techniques to help us achieve the previously mentioned goals of improving BPI patients' mental well-being.

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Section: Pediatric Bipolar Disordermentioning

confidence: 93%

“…As such, one must look to examine alterations in these core domains in younger populations. Studies have shown that children and adolescents with bipolar disorder demonstrate poor executive function [49] and emotional regulation [50].…”

Section: Pediatric Bipolar Disordermentioning

confidence: 99%

Neuroimaging in bipolar disorder: A critical review of current findings

Keener

Phillips²

2007

Curr Psychiatry Rep

102

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“…BD (n ϭ 22) and control (n ϭ 21) subjects were recruited as described (28,54). The National Institute of Mental Health (NIMH) Institutional Review Board approved the study.…”

Section: Methodsmentioning

confidence: 99%

“…These psychological processes are of interest because children with BD have difficulty categorizing facial emotions (27) and regulating both their attention (28) and their affect (29). These deficits may be related: children with BD may mislabel facial emotions because their affective response to a face disrupts emotion categorization; such mislabeling may contribute to inappropriate emotional responses to environmental stimuli, and thus to emotional dysregulation.…”

mentioning

confidence: 99%

Limbic hyperactivation during processing of neutral facial expressions in children with bipolar disorder

Rich

Vinton

Roberson‐Nay

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

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279

303

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Reflecting a paradigm shift in clinical neuroscience, many chronic psychiatric illnesses are now hypothesized to result from perturbed neural development. However, most work in this area focuses on schizophrenia. Here, we extend this paradigm to pediatric bipolar disorder (BD), thus demonstrating traction in the developmental psychobiology perspective. To study amygdala dysfunction, we examined neural mechanisms mediating face processing in 22 youths (mean age 14.21 ؎ 3.11 yr) with BD and 21 controls of comparable age, gender, and IQ. Event-related functional MRI compared neural activation when attention was directed to emotional aspects of faces (hostility, subjects' fearfulness) vs. nonemotional aspects (nose width). Compared with controls, patients perceived greater hostility in neutral faces and reported more fear when viewing them. Also, compared with controls, patients had greater activation in the left amygdala, accumbens, putamen, and ventral prefrontal cortex when rating face hostility, and greater activation in the left amygdala and bilateral accumbens when rating their fear of the face. There were no between-group behavioral or neural differences in the nonemotional conditions. Results implicate deficient emotion-attention interactions in the pathophysiology of BD in youth and suggest that developmental psychobiology approaches to chronic mental illness have broad applicability.amygdala ͉ faces ͉ functional MRI R ecently, psychology and psychiatry have witnessed a major paradigm shift: virtually all chronic adult mental illnesses are now thought to result from long-term perturbations in neural development. Two lines of research support this perspective: family-based͞longitudinal studies and neurobiological studies. Family-based and longitudinal studies implicate developmental perturbations in a range of conditions, including behavior disorders, substance abuse, mood disorders, and psychoses (1-3). However, virtually all research on developmental neurobiology focuses on schizophrenia, where data implicate a neural circuit connecting the dorsolateral prefrontal cortex, striatum, and hippocampus (4, 5). Neurocognitive correlates of schizophrenia, such as deficient working memory, are thought to result from dysfunction in this circuit (6). An important next step is the extension of the developmental neurobiological approach to other mental illnesses and other neural systems associated with information processing and emotion regulation.For several reasons, bipolar disorder (BD) is an ideal illness in which to expand the emerging developmental paradigm by conducting neurobiologically oriented developmental research. BD causes marked disruption in social, academic, and family function. Major questions persist concerning the boundaries of the condition in children; neurobiological data might ultimately resolve them. Most importantly, research in adult patients and animals implicates a circuit encompassing the amygdala, striatum, and ventral prefrontal cortex (VPFC) in the pathophysiology of BD (7). This circu...

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“…In 11-year-old children with oppositional-defiant disorder, Baving et al (2005) found smaller P300 amplitudes to both cues and targets in a CPT. Rich et al (2005) investigated the performance of children diagnosed with bipolar disorder in a spatial-cueing task. Both normal feedback and rigged feedback were used, intended to induce frustration.…”

Section: Other Disorders Of Childhoodmentioning

confidence: 99%