2020
DOI: 10.1002/dc.24676
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The impact of repeat fine‐needle aspiration in thyroid nodules categorized as atypia of undetermined significance or follicular lesion of undetermined significance: A single center experience

Abstract: Background Atypia of undetermined significance (AUS) or follicular lesion of undetermined significance (FLUS) is the most controversial category of the Bethesda System. The present study was conducted to compare the histological findings in a series of thyroid nodules diagnosed with AUS/FLUS after single or repeat fine needle aspiration (FNA) cytology. Methods Retrospective analysis of our institution's series of 514 patients with an initial diagnosis of AUS/FLUS between 11/2011 and 02/2020. Results Of 4887 FN… Show more

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Cited by 15 publications
(16 citation statements)
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References 31 publications
(67 reference statements)
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“…6,10 Malignancy rates above 30% were frequently reported in recent studies. 7,11 Moreover, higher frequency values like 52.5% and 55.5% were detected in other studies. 12,13 We showed -similar to the aforementioned articles-that the malignancy rate is higher than it was traditionally considered.…”
Section: Discussionmentioning
confidence: 46%
See 2 more Smart Citations
“…6,10 Malignancy rates above 30% were frequently reported in recent studies. 7,11 Moreover, higher frequency values like 52.5% and 55.5% were detected in other studies. 12,13 We showed -similar to the aforementioned articles-that the malignancy rate is higher than it was traditionally considered.…”
Section: Discussionmentioning
confidence: 46%
“…Overestimated malignancy rates may be calculated because of the bias for surgical candidate selection. 7 Clinical and ultrasonographic features, patients' preference for treatment and the experience of the medical center affect the patient selection for surgery. As a result, different malignancy rates were calculated in different studies.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…They propose management options for nodules such as observation, surgery, or repeat UG-FNAB. Marin et al [ 9 ] suggest that repeat UG-FNAB in cases of AUS/FLUS category increases detection of follicular adenomas. Focal or extensive but mild cytological and architectural atypia are insufficient to be assigned to a higher category, and atypia in follicular/lymphoid cells is classified as category III of TBSRTC [ 3 ].…”
Section: Discussionmentioning
confidence: 99%
“…Thus, AUS and FLUS do not provide a differential diagnosis between malignant and benign lesions. Some authors admit that it is the most controversial category of this classification [ 9 ]. The occurrence of two or more subsequent biopsy results with AUS/FLUS diagnosis makes these clinical situations even more complex.…”
Section: Introductionmentioning
confidence: 99%