The impact of primary tumor location on prognosis after colorectal lung metastasectomy

When left does not seem right: epigenetic and bioelectric differences between left- and right-sided breast cancer

“…Differences in L/R bilateral tumors have been reported for several cancer types, like breast (Kenney et al 2004 ; Garfinkel et al 1959 ), colon (Yang et al 2018 ; Baran et al 2018 ; Sponholz et al 2021 ), kidney (Ni et al 2021 ; Guo et al 2019 ), brain (Połczyńska et al 2021 ), ovary (He et al 2021 ), and eye (Hussain 2021 ). Particularly in breast tumors, in addition to the largely known increased L-side incidence (Busk and Clemmensen 1947 ; Roychoudhuri et al 2006 ), interesting differences in gene expression (Robichaux et al 2014 ; Mittwoch 2008 ), gland microbiota (Klann et al 2020 ), mitochondria distribution (Mishra and Chan 2014 ) and methylation profiles (Campoy et al 2016 ) have been reported.…”

Reply to the Letter to the Editor: Surgery, selection, or biology in lung metastasectomy for colorectal lung metastasectomy? PulMiCC may not provide all the answers but it does narrow down the question

“…On the other hand, we want to clarify the statement that it is unfair that we mentioned that the PulMiCC trial was stopped due to poor recruitment [2]. It was not our intention to be unfair; we just cited the conclusions of the PulMiCC trial:…”

Pulmonary metastasectomy—is the extent of resection worth reconsidering?

“…The PulMiCC Trial provided evidence supporting a randomized comparison of PME vs. no surgical resection from the ethical point of view. But to the best of our knowledge, the well-designed PulMiCC Trial was stopped due to poor patient recruitment so that the conclusion might not be sufficiently substantiated (10,14).…”