When left does not seem right: epigenetic and bioelectric differences between left- and right-sided breast cancer

Masuelli, Sofía; Real, Sebastián; Campoy, Emanuel; Branham, Marı́a Teresita; Marzese, Diego M.; Salomon, Matthew P.; Blas, Gerardo De; Arias, Rodolfo; Levin, Michael; Roqué, María

doi:10.1186/s10020-022-00440-5

Cited by 4 publications

(2 citation statements)

References 112 publications

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“…[ 106 ] Interestingly, bioelectrical differences were also found between left and right sided breast cancer. [ 107 ] Individual cells transforming into cancer depolarize as a very early step in the process. Figure 7A displays a voltage‐sensitive dyes imaging of depolarized cells decoupling from their mother tissue to undergo tumorigenesis.…”

Section: Electrical Properties Of Cancer Cell Populations and Tissuesmentioning

confidence: 99%

Nanotechnology and Cancer Bioelectricity: Bridging the Gap Between Biology and Translational Medicine

Moreddu

2023

Advanced Science

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Bioelectricity is the electrical activity that occurs within living cells and tissues. This activity is critical for regulating homeostatic cellular function and communication, and disruptions of the same can lead to a variety of conditions, including cancer. Cancer cells are known to exhibit abnormal electrical properties compared to their healthy counterparts, and this has driven researchers to investigate the potential of harnessing bioelectricity as a tool in cancer diagnosis, prognosis, and treatment. In parallel, bioelectricity represents one of the means to gain fundamental insights on how electrical signals and charges play a role in cancer insurgence, growth, and progression. This review provides a comprehensive analysis of the literature in this field, addressing the fundamentals of bioelectricity in single cancer cells, cancer cell cohorts, and cancerous tissues. The emerging role of bioelectricity in cancer proliferation and metastasis is introduced. Based on the acknowledgement that this biological information is still hard to access due to the existing gap between biological findings and translational medicine, the latest advancements in the field of nanotechnologies for cellular electrophysiology are examined, as well as the most recent developments in micro‐ and nano‐devices for cancer diagnostics and therapy targeting bioelectricity.

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Section: Electrical Properties Of Cancer Cell Populations and Tissuesmentioning

confidence: 99%

Nanotechnology and Cancer Bioelectricity: Bridging the Gap Between Biology and Translational Medicine

Moreddu

2023

Advanced Science

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“…Following publication of the original article (Masuelli et al 2022), we have been informed that first name and last name have been swapped for 1st, 2nd, 3rd, 6th, 8th, 9th and 10th author.…”

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confidence: 99%

Correction to: When left does not seem right: epigenetic and bioelectric differences between left and right‑sided breast cancer

Masuelli

Real

Campoy

et al. 2022

Mol Med

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The Yin and Yang of Breast Cancer: Ion Channels as Determinants of Left–Right Functional Differences

Masuelli

Real

McMillen

et al. 2023

IJMS

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Breast cancer is a complex and heterogeneous disease that displays diverse molecular subtypes and clinical outcomes. Although it is known that the location of tumors can affect their biological behavior, the underlying mechanisms are not fully understood. In our previous study, we found a differential methylation profile and membrane potential between left (L)- and right (R)-sided breast tumors. In this current study, we aimed to identify the ion channels responsible for this phenomenon and determine any associated phenotypic features. To achieve this, experiments were conducted in mammary tumors in mice, human patient samples, and with data from public datasets. The results revealed that L-sided tumors have a more depolarized state than R-sided. We identified a 6-ion channel-gene signature (CACNA1C, CACNA2D2, CACNB2, KCNJ11, SCN3A, and SCN3B) associated with the side: L-tumors exhibit lower expression levels than R-tumors. Additionally, in silico analyses show that the signature correlates inversely with DNA methylation writers and with key biological processes involved in cancer progression, such as proliferation and stemness. The signature also correlates inversely with patient survival rates. In an in vivo mouse model, we confirmed that KI67 and CD44 markers were increased in L-sided tumors and a similar tendency for KI67 was found in patient L-tumors. Overall, this study provides new insights into the potential impact of anatomical location on breast cancer biology and highlights the need for further investigation into possible differential treatment options.

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When left does not seem right: epigenetic and bioelectric differences between left- and right-sided breast cancer

Cited by 4 publications

References 112 publications

Nanotechnology and Cancer Bioelectricity: Bridging the Gap Between Biology and Translational Medicine

Nanotechnology and Cancer Bioelectricity: Bridging the Gap Between Biology and Translational Medicine

Correction to: When left does not seem right: epigenetic and bioelectric differences between left and right‑sided breast cancer

The Yin and Yang of Breast Cancer: Ion Channels as Determinants of Left–Right Functional Differences

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