The Impact of Previous Hbv Infection on The Course of Chronic Hepatitis C

Maria, Nicola De; Colantoni, Alessandra; Friedlander, Lois; Leandro, Gioacchino; İdilman, Ramazan; Harig, James M.; Thiel, David H. Van

doi:10.1111/j.1572-0241.2000.03371.x

Cited by 64 publications

(71 citation statements)

References 30 publications

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“…The prevalence of occult infection seems to be closely related to the prevalence of HBV infection in different parts of the world. Several investigators have shown an intermediate to high occurrence of HBV occult infection, both in serum and in liver tissue (1,2,4,(8)(9)(10)(11)(12)(13)(14)(15). In Brazil, particularly in the Southeast region, the prevalence of HBV infection is very low (21) and this may have contributed to our results of an HBV occult infection rate close to zero.…”

Section: Discussionmentioning

confidence: 59%

“…These results suggest that occult HBV infection may interfere with the clinical picture of chronic HCV infection, accelerating its evolution to cirrhosis (11). Evidence for previous HBV infection even in the absence of HBV DNA detection has been related to the severity of the disease in anti-HCV-positive chronic hepatitis patients (12) but these results were not confirmed by other investigators (13)(14)(15).…”

Section: Introductionmentioning

confidence: 80%

“…infections by HBV such as low HBV DNA and HBsAg levels (2), mutations in HBV DNA sequence (3), viral DNA integration in the host genome (4), infection of peripheral blood mononuclear cells (5), production of immune complexes containing HBV (6), altered host immune response (7), and interference of other viruses (mainly hepatitis C virus, HCV) (8)(9)(10)(11)(12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Low occurrence of occult hepatitis B virus infection and high frequency of hepatitis C virus genotype 3 in hepatocellular carcinoma in Brazil

Alencar

Gomes

Sitnik

et al. 2007

Braz J Med Biol Res

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Occult hepatitis B virus (HBV) infection has been reported among patients with hepatitis C virus (HCV) infection and hepatocellular carcinoma (HCC). Our aim was to evaluate the presence of occult HBV infection in patients with HCV-related liver cirrhosis (LC) with or without HCC in São Paulo, Brazil. Serum and liver tissue samples from 50 hepatitis B surface antigennegative patients with HCV-related LC who underwent liver transplantation at the University of São Paulo School of Medicine Hospital from 1993 to 2004 were divided into groups with LC only (N = 33) and with LC plus HCC (N = 17). HBV DNA was assayed for serum and paraffin-embedded liver tissue (tumoral and non-tumoral) using real time PCR and only 1 case with HCC had HBV DNA-positive serum. All liver samples were negative. HCV genotype 3 was detected in 17/39 (43.7%) cases. In conclusion, using a sensitive real time PCR directed to detect HBV variants circulating in Brazil, occult hepatitis B infection was not found among HCV-positive cirrhotic patients and was rarely found among HCV-positive HCC patients. These results are probably related to the low prevalence of HBV infection in our population. Furthermore, we have also shown that HCV genotype 3 is frequently found in Brazilian cirrhotic patients, particularly when they also have HCC. More studies involving a large number of cases should be carried out to confirm these data and to further characterize Brazilian HCV genotype isolates to elucidate genetic features that might be related to its carcinogenic potential.

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Section: Discussionmentioning

confidence: 59%

Section: Introductionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Low occurrence of occult hepatitis B virus infection and high frequency of hepatitis C virus genotype 3 in hepatocellular carcinoma in Brazil

Alencar

Gomes

Sitnik

et al. 2007

Braz J Med Biol Res

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“…Nosso achado vai contra a teoria da manutenção residual do vírus B neste cenário, sugerindo desta forma a ausência de seus epítopos em hepatócitos, ao menos em quantidades suficientemente capazes de induzir uma maior resposta citotóxica e fibrogênica, ou mesmo pautando a hipótese da supressão não citolítica de sua suposta replicação viral, exercido por células T através da liberação de citoquinas capazes de suprimir a transcrição de seu genoma sem causar dano celular 22 . Embora não realizada neste estudo, a diferenciação entre o padrão anti-HBcAg isolado e o perfil sorológico completo (anti-HBcAg[+] e anti-HBsAg[+]) para a avaliação da influência da infecção pregressa pelo VHB na hepatopatia do vírus C foi proposta por alguns autores, partindo do pressuposto de que a primeira situação estaria associada a um maior dano hepático 6,23 . Contudo, neste ponto a literatura tem demonstrado resultados conflitantes.…”

Section: Discussionunclassified

“…O curso da doença é dinâmico e altamente influenciado por uma gama de fatores exógenos e endógenos ao hospedeiro De fato, esta população apresenta marcadores de infecção pregressa pelo vírus B em maior frequência do que na população geral 4 . Estima-se que a prevalência de anti-HBcAg na ausência do antígeno de superfície (HBsAg) em indivíduos com hepatite C crônica seja da ordem de 20 a 30% 5,6 . No Brasil, um estudo realizado em Campinas, Estado de São Paulo, envolvendo 790 pré-doadores de sangue nos quais os exames de triagem revelaram anti-VHC(+), demonstrou que 30% dos mesmos apresentavam marcadores de infecção B pregressa 7 .…”

Section: Introductionunclassified

Influência da infecção pregressa pelo vírus da hepatite B na fibrose hepática em portadores de hepatite C crônica: avaliação retrospectiva de uma série de casos

Neto

Tengan

Cavalheiro

et al. 2010

Rev. Soc. Bras. Med. Trop.

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RESUMOIntrodução: A hepatite C é uma das principais causas de doença hepática em todo mundo. Apresenta um curso evolutivo dinâmico e influenciável por diversos co-fatores. Dentre eles, a infecção pregressa pelo vírus B (anti-HBcAg [+] e HBsAg [-]) tem se associado a pior prognóstico histológico e terapêutico. Este trabalho teve como objetivo analisar a associação entre a infecção pregressa pelo vírus B e fibrose hepática em portadores de hepatite C crônica, de maneira independente. Métodos: Foram revistos retrospectivamente prontuários médicos de pacientes infectados cronicamente pelo vírus C, atendidos consecutivamente durante um ano no ambulatório de Doenças Infecciosas e Parasitárias -HC FMUSP, quanto aos dados epidemiológicos, clínicos, laboratoriais e histológicos. A análise de independência do impacto da infecção pregressa pelo vírus B foi realizada através de modelo estatístico de regressão logística multivariado, considerando a detecção do anti-HBcAg como variável de exposição, sendo o desfecho a alteração estrutural histopatológica graus 3 e 4 (septos com formação de nódulos e cirrose). Resultados: 145 indivíduos foram avaliados pelo estudo, 47.2% com anti-HBcAg (+). O fator de risco mais comumente relatado foi transfusão de sangue e hemoderivados (35,9%). Embora necrose em saca-bocado tenha sido encontrada com maior frequência no grupo de infecção pregressa, a sorologia anti-HBcAg (+) não se associou à fibrose hepática avançada. Conclusões: A infecção pregressa pelo vírus B não parece acentuar a lesão estrutural desencadeada pela hepatite C crônica, após controle estatístico para outros co-fatores sabidamente capazes de influenciar a história natural desta infecção. Palavras-chaves: Hepatite C crônica/fisiopatologia. Anticorpos anti-hepatite B. Hepatite B oculta. ABSTRACTIntroduction: Hepatitis C is a major cause of liver disease worldwide. Its evolutionary course is dynamics and may be influenced by several cofactors. Among them, previous hepatitis B virus infection (anti-HBcAg [+] and HBsAg [-]) has been associated with worse histological and therapeutic prognosis. This study had the objective of independently assessing the relationship between previous hepatitis B infection and liver fibrosis in patients with chronic hepatitis C. Methods: The medical records of patients chronically infected with the hepatitis C virus who had been seen consecutively during a one-year period at the infectious and parasitic diseases outpatient clinic of HC FMUSP were retrospectively reviewed in relation to epidemiological, clinical and histological data. Analysis on the independence of the previous hepatitis B infection was performed using the statistical model of multivariate logistic regression. Detection of antiHBcAg was taken to be the independent variable. The outcome was taken to be grade 3 and 4 histopathological abnormality (septa with nodule formation and cirrhosis). Results: 145 subjects were evaluated in this study. 47.2% of them were anti-HBcAg (+). The main risk factor for infection was blood and blood der...

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Occult hepatitis B virus infection is associated with the development of hepatocellular carcinoma in chronic hepatitis C patients

Squadrito

Pollicino

Cacciola

et al. 2006

Cancer

121

150

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BACKGROUNDOccult hepatitis B virus (HBV) infection frequently occurs in patients with HBV surface antigen (HBsAg)‐negative chronic liver disease, and much evidence suggests that it is a risk factor for hepatocellular carcinoma (HCC) development. However, to the authors' knowledge, no follow‐up study has been performed to date evaluating HCC occurrence over time in chronic hepatitis patients with or without occult HBV infection.METHODSA cohort of the 380 HBsAg‐negative chronic hepatitis patients attending the study institution between 1991–2000 were evaluated and tested for occult HBV DNA by analysis of liver biopsy specimens.RESULTSThere were 135 patients (35.5%) with occult HBV and 245 patients (64.5%) without occult HBV. Cirrhosis was significantly associated with occult HBV infection (P = 0.01). One hundred thirty‐four of these patients were followed for a minimum of 50 months (median, 82.8 ± 32.6 mos). Fifty‐three patients (39%) were occult HBV carriers and 81 (61%) were not. Nine patients developed HCC during the follow‐up; eight were positive and one was negative for occult HBV (P = 0.002).CONCLUSIONSThe current observational cohort study showed that, among the HBsAg‐negative patients with chronic hepatitis, HCC develops for the most part in carriers of occult HBV. Therefore, the evaluation of HBV genomes in chronic hepatitis patients appears to be a powerful tool for the identification of individuals at higher risk of HCC development. Cancer 2006. © 2006 American Cancer Society.

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The Impact of Previous Hbv Infection on The Course of Chronic Hepatitis C

Abstract: The prevalence of anti-HBc is high among HCV-positive individuals. HCV-positive individuals who are anti-HBc positive have: 1) a higher prevalence of cirrhosis; 2) lower HCV-RNA levels; and 3) an impaired ability to respond to interferon treatment.

Cited by 64 publications

References 30 publications

Low occurrence of occult hepatitis B virus infection and high frequency of hepatitis C virus genotype 3 in hepatocellular carcinoma in Brazil

Low occurrence of occult hepatitis B virus infection and high frequency of hepatitis C virus genotype 3 in hepatocellular carcinoma in Brazil

Influência da infecção pregressa pelo vírus da hepatite B na fibrose hepática em portadores de hepatite C crônica: avaliação retrospectiva de uma série de casos

Occult hepatitis B virus infection is associated with the development of hepatocellular carcinoma in chronic hepatitis C patients

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