The impact of physical training on endocrine modulation, muscle physiology and sexual functions in elderly men

Revnic, C.; Nica, Adriana Sarah; Revnic, F.

doi:10.1016/j.archger.2007.01.046

Cited by 11 publications

(16 citation statements)

References 7 publications

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“…In addition, physical activity may partly intermediate its benefits through an induced increase in testosterone levels [54]. Another possible pathophysiologic linkage between MetS and ED is subclinical inflammation [55].…”

Section: Discussionmentioning

confidence: 99%

Erectile dysfunction, physical activity and metabolic syndrome: differences in markers of atherosclerosis

Pohjantähti‐Maaroos

Palomäki

Hartikainen

2011

BMC Cardiovasc Disord

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BackgroundErectile dysfunction (ED), impaired arterial elasticity, elevated resting heart rate as well as increased levels of oxidized LDL and fibrinogen associate with future cardiovascular events. Physical activity is crucial in the prevention of cardiovascular diseases (CVD), while metabolic syndrome (MetS) comprises an increased risk for CVD events. The aim of this study was to assess whether markers of subclinical atherosclerosis are associated with the presence of ED and MetS, and whether physical activity is protective of ED.Methods57 MetS (51.3 ± 8.0 years) and 48 physically active (PhA) (51.1 ± 8.1 years) subjects participated in the study. ED was assessed by the International Index of Erectile Function (IIEF) questionnaire, arterial elasticity by a radial artery tonometer (HDI/PulseWave™ CR-2000) and circulating oxLDL by a capture ELISA immunoassay. Fibrinogen and lipids were assessed by validated methods. The calculation of mean daily energy expenditure of physical exercise was based on a structured questionnaire.ResultsED was more often present among MetS compared to PhA subjects, 63.2% and 27.1%, respectively (p < 0.001). Regular physical exercise at the level of > 400 kcal/day was protective of ED (OR 0.12, 95% CI 0.017-0.778, p = 0.027), whereas increased fibrinogen (OR 4.67, 95% CI 1.171-18.627, p = 0.029) and elevated resting heart rate (OR 1.07, 95% CI 1.003-1.138, p = 0.04) were independently associated with the presence of ED. In addition, large arterial elasticity (ml/mmHgx10) was lower among MetS compared to PhA subjects (16.6 ± 4.0 vs. 19.6 ± 4.2, p < 0.001), as well as among ED compared to non-ED subjects (16.7 ± 4.6 vs. 19.0 ± 3.9, p = 0.008). Fibrinogen and resting heart rate were highest and large arterial elasticity lowest among subjects with both MetS and ED.ConclusionsMarkers of subclinical atherosclerosis associated with the presence of ED and were most evident among subjects with both MetS and ED. Thus, especially MetS patients presenting with ED should be considered at high risk for CVD events. Physical activity, on its part, seems to be protective of ED.Trial registrationClinicalTrials.gov NCT01119404

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Section: Discussionmentioning

confidence: 99%

Erectile dysfunction, physical activity and metabolic syndrome: differences in markers of atherosclerosis

Pohjantähti‐Maaroos

Palomäki

Hartikainen

2011

BMC Cardiovasc Disord

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“…It is interesting to find that green tea supplementation showed reduction in body weight, BMI, and lower lipid peroxidation in obese MetS patients [220]. In addition, physical activity may induce an increase in T levels [221], and thus, regular, moderate exercise for minimum of 30 minutes a day may improve erectile function in men with MetS [222].…”

Section: Lifestyle Modificationsmentioning

confidence: 99%

A Comprehensive Review of Metabolic Syndrome Affecting Erectile Dysfunction

Kaya

Sikka

Gür

2015

The Journal of Sexual Medicine

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Introduction Metabolic syndrome (MetS) is the most important public health issue threatening the health of men and women all over the world. Its current prevalence (i.e., approximately 30%) is continuously increasing. MetS by itself is considered a risk factor for erectile dysfunction (ED). Aim To focus on the definition epidemiology, pathogenesis, and possible mechanistic links between MetS and ED in order to provide guidelines for treating such individuals. Methods The search strategies yielded total records screened from PubMed. Main Outcome Measures Regardless of the definition, MetS consists of insulin resistance, hypertension, dyslipidemia, and obesity. MetS is not an end disease but is a disorder of energy utilization and storage. Results The prevalence of ED in patients with MetS is almost twice than in those without MetS, and about 40% of patients with ED have MetS. An important mechanism linking MetS and ED is hypogonadism. Conclusions Recognizing through ED, underlying conditions such as hypogonadism, diabetes and MetS might be a useful motivation for men to improve their health-related choices. The clinical management of MetS can be done by therapeutic interventions that include lifestyle modifications, hormone replacement alone or in combination with phosphodiesterase 5 inhibitors, and other pharmacological treatments.

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“…In obese men (BMI ≥ 30 kg/m 2 ) with ED, reduced calorie intake and increased physical activity can significantly reduce weight, decrease the concentrations of inflammatory markers (e.g. CRP) and improve erectile function (43–45). Similar results have been observed in men with the metabolic syndrome and comorbid ED (46).…”

Section: Can Cardiovascular Events Be Prevented By Intervention Follomentioning

confidence: 99%

Erectile dysfunction and coronary artery disease prediction: evidence-based guidance and consensus

Jackson

Boon

Eardley

et al. 2010

International Journal of Clinical Practice

204

155

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Summary A significant proportion of men with erectile dysfunction (ED) exhibit early signs of coronary artery disease (CAD), and this group may develop more severe CAD than men without ED (Level 1, Grade A). The time interval among the onset of ED symptoms and the occurrence of CAD symptoms and cardiovascular events is estimated at 2–3 years and 3–5 years respectively; this interval allows for risk factor reduction (Level 2, Grade B). ED is associated with increased all‐cause mortality primarily due to increased cardiovascular mortality (Level 1, Grade A). All men with ED should undergo a thorough medical assessment, including testosterone, fasting lipids, fasting glucose and blood pressure measurement. Following assessment, patients should be stratified according to the risk of future cardiovascular events. Those at high risk of cardiovascular disease should be evaluated by stress testing with selective use of computed tomography (CT) or coronary angiography (Level 1, Grade A). Improvement in cardiovascular risk factors such as weight loss and increased physical activity has been reported to improve erectile function (Level 1, Grade A). In men with ED, hypertension, diabetes and hyperlipidaemia should be treated aggressively, bearing in mind the potential side effects (Level 1, Grade A). Management of ED is secondary to stabilising cardiovascular function, and controlling cardiovascular symptoms and exercise tolerance should be established prior to initiation of ED therapy (Level 1, Grade A). Clinical evidence supports the use of phosphodiesterase 5 (PDE5) inhibitors as first‐line therapy in men with CAD and comorbid ED and those with diabetes and ED (Level 1, Grade A). Total testosterone and selectively free testosterone levels should be measured in all men with ED in accordance with contemporary guidelines and particularly in those who fail to respond to PDE5 inhibitors or have a chronic illness associated with low testosterone (Level 1, Grade A). Testosterone replacement therapy may lead to symptomatic improvement (improved wellbeing) and enhance the effectiveness of PDE5 inhibitors (Level 1, Grade A). Review of cardiovascular status and response to ED therapy should be performed at regular intervals (Level 1, Grade A).

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The impact of physical training on endocrine modulation, muscle physiology and sexual functions in elderly men

Cited by 11 publications

References 7 publications

Erectile dysfunction, physical activity and metabolic syndrome: differences in markers of atherosclerosis

Erectile dysfunction, physical activity and metabolic syndrome: differences in markers of atherosclerosis

A Comprehensive Review of Metabolic Syndrome Affecting Erectile Dysfunction

Erectile dysfunction and coronary artery disease prediction: evidence-based guidance and consensus

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