The Impact of Oxidative Stress on Dopaminergic Neurotransmission

Deslauriers, Jessica; Sarret, Philippe; Grignon, Sylvain

doi:10.1007/978-1-4939-0440-2_10

Cited by 2 publications

(1 citation statement)

References 71 publications

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“…The role of oxidative stress in health and disease of animals has been critiqued by some researchers [27,28]. Metabolic diseases, heat stress and nutrition have been documented as well as performance parameters, immune defense, milk production and energy balance [29,30].…”

Section: Antioxidants In Health and Diseasementioning

confidence: 99%

Stress, Natural Antioxidants and Future Perspectives

Seyidoğlu¹,

Aydin²

2020

The Health Benefits of Foods - Current Knowledge and Further Development

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Stress can exist by a variety of daily challenges related to obesity, other eating disorders, long-term health issues and immune system suppression. Free radicals derived from oxygen, called reactive oxygen species, reactive nitrogen species and similarly antioxidants are part of the body's natural functioning. Oxidative stress occurs when free radicals and antioxidants are out of balance. The prooxidantantioxidant balance is assessed by determination of both oxidant and antioxidant status, which can be measured simultaneously in blood and tissue. Dietary or natural antioxidants play an important role in helping the endogenous antioxidants in scavenging the excess of free radicals. Antioxidant supplements include several important substances such as beta carotene, lutein, phycocyanin and zeaxanthin, which are rich in vegetables, fruits and natural foods. All these contents have a key role in growth, immunity and lifetime quality. Still, high dose of the natural foods can cause the organism, not to assimilate the wastes by the mechanism. In this chapter, we'll inquire to explain the oxidative and antioxidative mechanisms and balance via importance of the natural antioxidants to life quality. For this purpose, oxidative stress, related diseases, antioxidants and their importance will be reviewed, and the correlation between natural antioxidants and health will be presented.

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Section: Antioxidants In Health and Diseasementioning

confidence: 99%

Stress, Natural Antioxidants and Future Perspectives

Seyidoğlu¹,

Aydin²

2020

The Health Benefits of Foods - Current Knowledge and Further Development

View full text Add to dashboard Cite

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Mitochondrial Dysfunction in Schizophrenia: Determination of Mitochondrial Respiratory Activity in a Two-Hit Mouse Model

et al. 2016

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Schizophrenia is a chronic mental illness in which mitochondrial dysfunction has been suggested. Our laboratory recently developed a juvenile murine two-hit model (THM) of schizophrenia based on the combination of gestational inflammation, followed by juvenile restraint stress. We previously reported that relevant behaviors and neurochemical disturbances, including oxidative stress, were reversed by the antioxidant lipoic acid (LA), thereby pointing to the central role played by oxidative abnormalities and prompting us to investigate mitochondrial function. Mitochondrial activity was determined with the MitoXpress® commercial kit in two schizophrenia-relevant regions (prefrontal cortex (PFC) and striatum). Measurements were performed in state 3, with substrates for complex I- and complex II-induced respiratory activity (IRA). We observed an increase in complex I IRA in the PFC and striatum in both sexes but an increase in complex II activity only in males. LA treatment prevented this increase only in complex II IRA in males. Expression levels of the different respiratory chain complexes, as well as fission/fusion proteins and protein carbonylation, were unchanged. In conclusion, our juvenile schizophrenia THM shows an increase in mitochondrial activity reversed by LA, specifically in complex II IRA in males. Further investigations are required to determine the mechanisms of these modifications.

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The Impact of Oxidative Stress on Dopaminergic Neurotransmission

Cited by 2 publications

References 71 publications

Stress, Natural Antioxidants and Future Perspectives

Stress, Natural Antioxidants and Future Perspectives

Mitochondrial Dysfunction in Schizophrenia: Determination of Mitochondrial Respiratory Activity in a Two-Hit Mouse Model

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