The Impact of Osteopontin Gene Variations on Multiple Sclerosis Development and Progression

Comi, Cristoforo; Cappellano, Giuseppe; Orilieri, Elisabetta; Buttini, Sara; Ghezzi, Laura; Galimberti, Daniela; Guerini, Franca Rosa; Barizzone, Nadia; Perla, Franco; Leone, Maurizio; D’Alfonso, Sandra; Caputo, Domenico; Scarpini, Elio; Cantello, Roberto; Dianzani, Umberto

doi:10.1155/2012/212893

Cited by 36 publications

(30 citation statements)

References 29 publications

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“…For its action in the regulation of immune system, OPN has been recognized to have a role in the development/progression of several autoimmune diseases, such as multiple sclerosis (16,17,18,19) rheumatoid arthritis (20,21), psoriasis (22) and Graves' disease (23).…”

Section: Introductionmentioning

confidence: 99%

Increased circulating osteopontin levels in adult patients with type 1 diabetes mellitus and association with dysmetabolic profile

Barchetta¹,

Alessandri

Bertoccini³

et al. 2016

European Journal of Endocrinology

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Objective: Osteopontin (OPN) is a sialoprotein implicated in different immunity and metabolic pathways. Capable of activating dendritic cells and inducing Th1-Th17-mediated tissue damage, OPN plays a significant role in the development/progression of several autoimmune diseases; interestingly, it was also shown that OPN participates in the acute pancreatic islets response to experimentally induced diabetes in non-obese diabetic (NOD) mice. Furthermore, OPN promotes adipose tissue dysfunction, systemic inflammation and insulin resistance. Our aims of this study were to evaluate circulating OPN levels in adult patients with type 1 diabetes mellitus (T1DM) compared to non-diabetic control participants and to unravel clinical and biochemical correlates of OPN concentration. Design: Case-control study. Methods: We enrolled 54 consecutive T1DM patients referred to our diabetes outpatient clinic at Sapienza University of Rome and 52 healthy sex and age-comparable controls. The study population underwent clinical evaluation, blood sampling for biochemistry and complete screening for diabetes complications. Serum OPN levels were measured by MILLIPLEX Multiplex Assays Luminex. Results: T1DM patients had significantly higher serum OPN levels than controls (17.2G12.9 vs 10.5G11.6 mg/ml, PZ0.009). OPN levels correlated with T1DM, higher blood pressure, BMI, creatinine, g-GT, ALP and lower HDL; the association between high OPN levels and T1DM was independent from all confounders. No correlation was shown between OPN and HbA1c, C-peptide, insulin requirement, co-medications and diabetes duration. Conclusions: This study demonstrates for the first time in a case-control study that adults with T1DM have increased serum OPN levels, and that higher OPN concentrations are associated with an unfavorable metabolic profile in these patients.

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Section: Introductionmentioning

confidence: 99%

Increased circulating osteopontin levels in adult patients with type 1 diabetes mellitus and association with dysmetabolic profile

Barchetta¹,

Alessandri

Bertoccini³

et al. 2016

European Journal of Endocrinology

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“…Caillier et al found that patients carrying at least one wild-type 1284 A/4 allele were less likely to have a mild disease course [2]. Hensiek et al found no effect of SNPs located in exons 6 and 7 of OPN on the clinical severity of MS [6], while Comi et al reported the role of OPN variation on MS development and progression; however, they did not discuss its effect on disease severity [4].…”

Section: Discussionmentioning

confidence: 99%

Polymorphism of the osteopontin gene and clinical course of multiple sclerosis in the Polish population

Biernacka-Łukanty¹,

Michałowska-Wender²,

Michalak³

et al. 2015

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“…+1239A and −156/GG homozygosity was associated with slower disease progression. Moreover, patients homozygous for +1239A showed lower relapse rate than those carrying +1239C [61].…”

Section: Multiple Sclerosismentioning

confidence: 91%

Osteopontin (OPN) Gene Polymorphisms and Autoimmune Diseases

Kaleta¹

2017

Genetic Polymorphisms

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Osteopontin (OPN) is a pleiotropic protein, important in bone remodeling and immune system signaling. OPN is synthesized in a variety of cells and tissues. It can be found not only in bone cells but also in immune cells (B and T lymphocytes, natural killer (NK) cells, natural killer T (NKT) cells, macrophages, neutrophils, and dendritic cells). OPN regulates T-helper 1/T-helper 2 (Th1/Th2) balance, stimulates B cells to antibodies production, regulates macrophages and neutrophils function, and activates dendritic cells. A number of factors, including hormones, cytokines, and polymorphisms of promoter region of OPN gene, regulate protein expression. OPN and variants of the OPN gene have been associated with the pathogenesis of multiple disorders, including systemic lupus erythematosus, multiple sclerosis, rheumatoid arthritis, systemic sclerosis, inlammatory bowel diseases, asthma, type 1 diabetes, and many other. However, some studies gave diferent or inconclusive results. Thus, the role of OPN polymorphic variants in autoimmune diseases needs to be beter deined and explored as a diagnostic and therapeutic target to monitor and treat immune-mediated conditions.

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The Impact of Osteopontin Gene Variations on Multiple Sclerosis Development and Progression

Cited by 36 publications

References 29 publications

Increased circulating osteopontin levels in adult patients with type 1 diabetes mellitus and association with dysmetabolic profile

Increased circulating osteopontin levels in adult patients with type 1 diabetes mellitus and association with dysmetabolic profile

Polymorphism of the osteopontin gene and clinical course of multiple sclerosis in the Polish population

Osteopontin (OPN) Gene Polymorphisms and Autoimmune Diseases

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