Increased circulating osteopontin levels in adult patients with type 1 diabetes mellitus and association with dysmetabolic profile

Barchetta, Ilaria; Alessandri, Cristiano; Bertoccini, Laura; Cimini, Flavia Agata; Taverniti, L.; Franco, Manuela Di; Fraioli, A; Baroni, Marco Giorgio; Cavallo, Maria Gisella

doi:10.1530/eje-15-0791

Cited by 27 publications

(22 citation statements)

References 30 publications

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“…This finding is in agreement with a previous study conducted in adult T1DM patients (14). Also, Gordin et al (22), in a 10-year follow-up study on a cohort of adult patients with T1DM, demonstrated that serum OPN level was an independent predictor of DN, of cardiovascular events, and of all-cause mortality.…”

Section: Discussionsupporting

confidence: 94%

“…This finding is in agreement with the findings of Karamizadeh et al (13) who found increased serum OPN levels in pediatric patients with T1DM compared with healthy children in an Iranian study. Also, our findings are in accordance with previous studies on adult T1DM patients (14). Aspord et al (15) studied the pattern of expression of 524 immune-related genes in the Langerhans cells of diabetic mice and found OPN as one of the early genes that was expressed in the primary phases of diabetes and concluded that OPN may play a vital role in T1DM.…”

Section: Discussionsupporting

confidence: 94%

“…The only previous study done for assessment of OPN in pediatric patients by Karamizadeh et al (13) did not investigate the presence of clinical and biochemical determinants of high OPN levels. However, our findings are in agreement with a previous study conducted on adult patients with T1DM which demonstrated that circulating OPN levels directly correlate with higher BMI, SBP, and DBP, and lower HDL, but not with diabetes complications, insulin dose, C-peptide level, or disease duration (14). Moreover, the serum OPN levels directly correlated with microalbuminuria.…”

Section: Discussionsupporting

confidence: 93%

“…Similar results were reported by Gordin et al (22) who also found an association between higher OPN levels and microalbuminuria at baseline in a cohort study conducted on a large population of adult patients with T1DM. On the other hand, Barchetta et al (14) did not find a significant correlation between serum OPN and microalbuminuria.…”

Section: Discussionmentioning

confidence: 88%

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The Role of Osteopontin in the Pathogenesis and Complications of Type 1 Diabetes Mellitus in Children

Talat

Sherief²,

Elsaadany³

et al. 2016

Jcrpe

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Objective:Type 1 diabetes mellitus (T1DM) is the most common chronic metabolic disorder of childhood and adolescence. Osteopontin plays a significant role in the development and progression of several autoimmune diseases. Moreover, osteopontin promotes adipose tissue inflammation, dysfunction, and insulin resistance. To investigate the levels of serum osteopontin in pediatric patients with T1DM and to explore if these levels have a role in the prediction of diabetes complications.Methods:This was a case–control study conducted at the Endocrinology unit of the Children’s Hospital of Zagazig University in Egypt, from October 2014 to December 2015. Sixty patients with T1DM and 60 healthy subjects were enrolled. A detailed medical history was taken from all patients/parents. A full clinical examination including ophthalmoscopy was performed on all patients. Fasting blood glucose, hemoglobin A1c (HbA1c), urine albumin/creatinine ratio, and serum osteopontin levels were also determined in all subjects.Results:Patients with T1DM had significantly higher serum osteopontin levels compared with controls (mean ± standard deviation: 13.7±3.4 μg/L vs. 8.9±2.9 μg/L, p<0.001). Also, serum osteopontin concentrations were higher in patients with microalbuminuria than in patients with normal albumin excretion rate and in the control group. Similarly, those who had retinal disease had higher osteopontin concentrations than those without (16.8±2 vs. 12.4±3 mg/L; p=0.005). Serum osteopontin levels correlated with a diagnosis of T1DM, and in diabetic patients, correlated with higher systolic and diastolic blood pressure, body mass index values and with lower high density lipoprotein values, diagnosis of retinopathy, and microalbuminuria. No correlation was found between osteopontin levels and HbA1c, insulin dose, co-medications, and diabetes duration in T1DM patients. The association between high osteopontin levels and T1DM was independent from all confounders.Conclusion:This study shows that increased osteopontin levels are independently associated with T1DM in pediatric patients and supports the hypothesis that osteopontin may have a role in the prediction of microvascular diabetes complications.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 88%

See 2 more Smart Citations

The Role of Osteopontin in the Pathogenesis and Complications of Type 1 Diabetes Mellitus in Children

Talat

Sherief²,

Elsaadany³

et al. 2016

Jcrpe

View full text Add to dashboard Cite

show abstract

“…Therefore, several studies have been performed to assess the association of OPN and predisposition to T1D. This protein has been found to be elevated in pediatric and adult patients with T1D [104][105][106]. Moreover, OPN has correlated with some clinical and biochemical parameters in T1D patients, including higher body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), lower high-density lipoprotein (HDL), and microalbuminuria [104,107].…”

Section: Type 1 Diabetesmentioning

confidence: 99%

Osteopontin (OPN) Gene Polymorphisms and Autoimmune Diseases

Kaleta¹

2017

Genetic Polymorphisms

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Osteopontin (OPN) is a pleiotropic protein, important in bone remodeling and immune system signaling. OPN is synthesized in a variety of cells and tissues. It can be found not only in bone cells but also in immune cells (B and T lymphocytes, natural killer (NK) cells, natural killer T (NKT) cells, macrophages, neutrophils, and dendritic cells). OPN regulates T-helper 1/T-helper 2 (Th1/Th2) balance, stimulates B cells to antibodies production, regulates macrophages and neutrophils function, and activates dendritic cells. A number of factors, including hormones, cytokines, and polymorphisms of promoter region of OPN gene, regulate protein expression. OPN and variants of the OPN gene have been associated with the pathogenesis of multiple disorders, including systemic lupus erythematosus, multiple sclerosis, rheumatoid arthritis, systemic sclerosis, inlammatory bowel diseases, asthma, type 1 diabetes, and many other. However, some studies gave diferent or inconclusive results. Thus, the role of OPN polymorphic variants in autoimmune diseases needs to be beter deined and explored as a diagnostic and therapeutic target to monitor and treat immune-mediated conditions.

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The potential role of the osteopontin–osteocalcin–osteoprotegerin triad in the pathogenesis of prediabetes in humans

et al. 2017

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AimsTo examine the relationship between hormones involved in bone remodeling and glucose metabolism alterations in prediabetes.MethodsIndividuals (n = 43) with NGT (BMI = 31.1 ± 1.1 kg/m2) and individuals (n = 79) with impaired glucose regulation (IGR) (BMI = 31.9 ± 1.2 kg/m2) including subjects with IFG, IGT, and IFG-IGT underwent OGTT and DXA. Osteopontin (OPN), osteocalcin (OCN), osteoprotegerin (OPG), and PTH levels were measured at fasting. Beta-cell function was calculated using C-peptide deconvolution. Dynamic indexes of insulin sensitivity were calculated from OGTT. A subgroup underwent to a euglycemic hyperinsulinemic clamp with 3-3H-glucose to estimate the endogenous glucose production (EGP) and insulin-mediated body glucose disposal (TGD/SSPI). ResultsOPN was higher in IGR compared to NGT (5.3 ± 0.5 vs. 3.3 ± 0.2 μg/mL; p = 0.008) and in isolated IGT compared to IFG and IFG-IGT (6.3 ± 0.5 vs. 4.5 ± 0.3 and 5.4 ± 0.5 μg/mL; p = 0.02). OCN was similar in IFG and NGT but lower in IGT and IFG-IGT compared to NGT (7.2 ± 0.3 and 5.4 ± 0.2 vs. 8.3 ± 0.3 ng/mL; p < 0.01). OPN was positively correlated with HbA1c, fasting and 2 h plasma glucose and PTH. OCN was negatively correlated with body fat, 2 h plasma glucose, insulin and positively correlated with Stumvoll index. OPG correlated with TGD/SSPI (r = − 0.29; p < 0.05), EGP, and hepatic insulin resistance index in IGR (r = 0.51, r = 0.43; p < 0.01). There was no correlation between PTH and insulin sensitivity or Beta-cell function parameters.ConclusionsIn prediabetes, hormones known to be involved in bone remodeling may affect glucose metabolism before overt T2DM occurs with tissue-specific mechanisms.Electronic supplementary materialThe online version of this article (10.1007/s00592-017-1065-z) contains supplementary material, which is available to authorized users.

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Increased circulating osteopontin levels in adult patients with type 1 diabetes mellitus and association with dysmetabolic profile

Cited by 27 publications

References 30 publications

The Role of Osteopontin in the Pathogenesis and Complications of Type 1 Diabetes Mellitus in Children

The Role of Osteopontin in the Pathogenesis and Complications of Type 1 Diabetes Mellitus in Children

Osteopontin (OPN) Gene Polymorphisms and Autoimmune Diseases

The potential role of the osteopontin–osteocalcin–osteoprotegerin triad in the pathogenesis of prediabetes in humans

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